Collaborative Research Initiatives Pioneering Kidney Research for a Healthier Future
Donor Network West’s contri ution to Human Cell Atlas
Advancing Kidney Health through Innovation
Exploring Breakthroughs in Kidney Disease Treatment and Transplantation At Donor Network West, we are committed to advancing kidney health through research that bridges science and patient care. Our projects are shaping the future of kidney transplantation and disease management.
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Project: Apollo
PURPOSE: The purpose of this study is to test kidney donors and recipients for APOL1 gene variants to see how this gene may impact people who receive a kidney transplant and those who donated a kidney. IMPACT: This study is being done to improve outcomes after kidney donation and kidney transplantation.
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Project: Tabula
Sapiens
Tabula Sapiens is a human cell atlas of nearly half a million cells from 24 organs of human donors. This work is the product of the Tabula Sapiens Consortium. IMPACT: During the last several years, Donor Network West has exclusively identified more than 20 donors to procure many organs and tissues including kidneys for this high-impact project.
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Project: Cell-Cell
Communication
OBJECTIVE: Exploring how vascular endothelial cells and epithelial cells communicate in the kidney. IMPACT: Identifying pathways that may improve kidney preservation and transplant success. NEXT STEP: Translating findings into donor management protocols to optimize kidney health pre- and post-transplant.
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Project: dGTEx
The Developmental Genotype-Tissue Expression (dGTEx) project is a National Institute of Health (NIH) initiative to establish gene expression profiles from 120 pediatric donors. This will pave the way to better understand the impact of genomic variation on complex traits and diseases. IMPACT: Donor Network West has identified 5 pediatric organ donors where a large number of organs and tissues including kidneys have been procured for this multicenter nationwide project.
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Project: HuBMAP
OBJECTIVE: The Human BioMolecular Atlas Program (HuBMAP) aims to build a map of healthy cells to unravel the connections among 37 trillion cells throughout the body. IMPACT: Determining how relationships among cells in di erent organs and tissues can a ect the health of an individual. NEXT STEP: Donor Network West has identified one donor for this project, contributing to this e ort to understand cellular interactions and their impact on health.
Highlight Impact:
Our collaborative e orts are designed to end deaths on the waitlist by improving organ preservation, supporting families, and streamlining processes. Together, these projects represent a significant step forward in the fight against kidney disease.
Interested in learning more about these groundbreaking projects or collaborating with us?
@mydnwest
CA | NV
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