Effect of operational parameters on the adsorption of rifampicin by low cost material Erwin Onyekachukwu 1 , H. Nesbitt 1 , S. Tretsiakova 2 , H.M. Coleman 1 1 School of Pharmacy and Pharmaceutical Sciences, Ulster University, United Kingdom, 2 Belfast School of Architecture and Built Environment, Ulster University, United Kingdom Due to an increase in world population and improved life expectancy, antibiotic consumption has increased. Antibiotics are used to meet several health challenges in both humans and animals. Waste water treatment plants contributeto the release of antibiotics intothe aquatic environment and antibiotic resistance 1 . Antibiotics are usually detected in low concentrations of10-100μg/L. The removal of antibiotics from water bodies is therefore important. Lignocellulosic materials have been utilized for the effective adsorption of various antibiotics found in wastewater 2 . Lignocellulosic materialsareutilized due totheirhigh degree of porosity and wide surface area. The aim of this study is to investigate the adsorption capacity of acid modified sawdust in the removal of rifampicin. Rifampicin was used in this study because of it known resistance to some bacteria such as Mycobacteriumtuberculosis 3 . The sawdust was washed, blended, and sieved to different particle ranges of 90-850μm. A size range of 180-250μm was selected. Sawdust was treated by mixing with 2M sulphuric acid for 24 hours. For thisstudy, thepH of the solution, initial concentration, contact time, and temperatureofthe batch adsorption of ripfampicin were investigated on raw and treated sawdust. Maximum adsorption was achieved at pH 3 with the treated sawdust having the highest removal efficiency (73%) compared to that of the raw sawdust (62.6%). At an initial concentration of25μg/ml at pH 7, the treated sawdust had a removal efficiency of 52.45% compared to the raw sawdust 32.79%. Also, the result revealed that at a temperature of 35°C, treated sawdust had the highest removal efficiency of 55.6% compared to that of raw sawdust, which was 34.62%. The contact time shows that the treated sawdust had the highest removal efficiency of 57.20% after 48 hours of shaking compared to the raw sawdust, which had a removal efficiency of 46.29%. The efficient features of the lignocellulose material prepared from the sawdust present a possible adsorbentfor the removal of ripfampicin from waste water. References 1. Akinsanmi, O., Kaya, S., Tretsiakova-McNally, S., Arnscheidt, J. and Coleman, H.M., 2019, July. Tackling Antimicrobial Resistance: Adsorption of meropenem and ciprofloxacin on lignocellulosic substrate from sawdust. In European Waste Water Management Conference.Bankole, D.T., Oluyori, A.P. and Inyinbor, A.A., 2023. 2. The removal of pharmaceutical pollutants from aqueous solution by Agro-waste. Arabian Journal of Chemistry, 16(5), p.104699.Minh, L.T.H. and Linh, N.N., 2023. Effectiveness and safety of bedaquiline-based, modified all-oral 9–11-month treatment regimen for rifampicin-resistant tuberculosis in Vietnam.
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