Anisotropic and amphiphilic porous silica material provide chemically selective environments for simultaneous delivery of curcumin and quercetin in biosystem Akanksha Dohare, Swathi Sudhakar, Björn Brodbeck, Ashutosh Mukherjee, Marc Brecht, Andreas Kandelbauer, Erik Schäffer, Hermann A. Mayer IIT Kanpur, India For drug delivery, porous silica materials are frequently utilized. However, mechanisms for delivering numerous medications at the same time are limited. Anisotropic and amphiphilic dumbbell core-shell silica microparticles with chemically selective environments can load and release two medicines at the same time, as demonstrated here. A huge dense lobe and a smaller hollow hemisphere make up the dumbbells. The shells of both portions feature mesoporous channels, according to electron microscope photographs. A correctly calibrated stirring speed and the use of ammonium fluoride as an etching agent dictate the shape and surface anisotropy of the particles in a simple etching procedure. The zeta potentials of the surface of the dense lobe and the tiny hemisphere differ, which is consistent with changes in dye and drug loading. The two polyphenols curcumin (Cur) and quercetin (QT) concentrate in separate compartments of the particles, according to confocal Raman microscopy and spectroscopy. The overall drug loading efficiency of Cur plus QT for amphiphilic particles is high, but it differs significantly between Cur and QT when compared to controls of core-shell silica microspheres and evenly charged dumbbell microparticles. Furthermore, cancer cell inhibitory effects of Cur and QT laden microparticles differ. In compared to the controls, the dual drug loaded amphiphilic microparticles exhibit the maximum activity. In the long run, amphiphilic particles may enable new medication delivery techniques. References 1. Dong, H. J.; Brennan, J. D. J Mater Chem 2012, 22, (26), 13197-13203. 2. Maisch, J.; Jafarli, F.; Chassé, T.; Blendinger, F.; Konrad, A.; Metzger, M.; Meixner, A. J.; Brecht, M.; Dähne, L.; Mayer, H. A. Chemical Communications 2016, 52, (100), 14392-14395.
P17
© The Author(s), 2023
Made with FlippingBook Learn more on our blog