Synthesis, characterization and antimicrobial studies of transition metal complexes of Schiff base derived from salicylaldehyde and l-tyrosine amino acid Tunmise Eugene-Osoikhia (Nee Adebesin) 1 , Tunmise Eugene-Osoikhia 2 1 University of Ibadan, Nigeria, 2 Department of Chemistry, University of Ibadan, Nigeria Tridentate Schiff base Salicylidene-tyrosine (H2L) of biological importance obtained from salicyaldehyde and L-tyrosine and their Mn(II), Fe(II), Co.(II), Cu(II) and Ni(II) complexes have been synthesised in 1:1 stochiometric ratio and characterised on the basis of their solubility , metal analysis, infrared, UV-Visible and magnetic measurements. The synthesised complexes have different shades of colour and decomposed at a temperature above 360oC. Salicylidene-tyrosine behaved as a tridentate ligand coordinating to the metals through the azomethine nitrogen atom, the oxygen atom of hydroxyl group of COOH and the phenolic oxygen to give an octahedral geometry. The electronic spectra were consistent with the proposed octahedral geometry around the metal ions. The metal complexes were screened for their antimicrobial activities against Staphylococcus aureus (ATCC 12600), Escherichia.coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 10145), Bacillus subtilis (ATCC 39090), Salmonella typhi (ATCC 6539), Klebsiella pneumonia (ATCC 35657), Candida albicans (ATCC 10231), Penicillium notatum (ATCC 20269), Rhizopus stolonifer (ATCC 14037) and Aspergillus niger (ATCC 16888). The copper complex [Cu(L)(H2O)3].H2O exhibited the highest activity in all the organisms tested It is active against all microorganisms tested at virtually all concentrations References 1. Sasi, S., Prathapachandra Kurup, M. Rand Suresh, E., J. Chem. Crystallogr, 37.1 (2006) 31. 2. Floriani, C., Fiallo, M., Chiesi-Villa, Aand Guastini, C., Dalton Trans, (1987) 1367. 3. Singh, H., Sharma, L. M., Gupta, M. Kand Varshney, A. K., Bull. Pol. Acad. Sci., Chem. 47.2 (1999) 103. 4. Nath, M.., Pokharia, S. and Yadav, R..,Coord. Chem. Rev., 215 (2001) 99. 5. Singh, H. L., Spectrochim. Acta, Part A.,76.2 (2010) 253. 6. Clifford, P., Singh, S., Stjernsward, J andKlein, G., Cancer Res., 27.12 (1967) 2578. 7. Chohan, Z. H., Praveen, M. and Ghaffar,A., Met.-Based Drugs., 45 (1997) 267. 8. Bromfield, R. J., Dainty, R. H., Gillard,R. D and Heaton, B.T., Nature., 223.5207 (1969) 735. 9. Remko, M., Fitz, D., Broer, R and Rode,B. M., J. Mol. Model., 17 (2011) 3117. 10. Muche, S and Hołynska, M., J. Mol.Struct., 1142 (2017) 168. 11. Chohan, Z. H., Praveen M and Ghaffar,A., Met.-Based Drugs., 4.5 (1997) 267. 12. Chohan, Z. H., Praveen, M and Ghaffaf,A., Synth. React. Inorg. Met.-Org. Chem., 28.10 (1998) 1673. 13. Moradi-Shoeili, Z., Amini, Z., Boghaei,D.M and Notash, B., Polyhedron 53(2013) 76. 14. Kureshy, R., Khan, N., Abdi, S., Patel, Sand Iyer, P., J. Mol. Catal. A: Chem., 150 (1999) 175. 15. Mounika, K., Anupama, B., Pragathi, Jand Gyanakumari, C., BanglaJOL J.S.R., 2.3 (2010) 513. 16. Rîmbu, C., Danac, R. and Pui, A., Chem. Pharm. Bull., 62.1 (2014) 12. 17. Sun, R. X., Li, J. Z., Zhang, H. Q., Pang,X. Z., Fu, Y. S and Cui, J. Z., Curr. Org. Chem., 16.23 (2012) 2868. 18. Casella, L and Gullotti, M., Inorg.Chem., 25.90 (1986) 1293. 19. Jain, A., Goyal, R. and Agarwal, D. D.,J. Inorg. Nucl. Chem., 43.9 (1981) 2005. 20. Geary, W. J., Coord. Chem. Rev., 7(1971) 81.
P22
© The Author(s), 2023
Made with FlippingBook Learn more on our blog