Gelatin-coated copper-based Metal-Organic Framework for controlled insulin delivery: possibility toward oral delivery system Pawan Kumar, Navpreet Kaur, Pranav Tiwari, Anoop Kumar Gupta, Shaikh M. Mobin Department of Chemistry, Indian Institute of Technology, India In the current era, the development of non-toxic, hemocompatible materials for controlled insulin delivery is a great challenge for researchers. In this study, we demonstrate the design of a novel linker, 5,5'-((pyridine-2,6- diylbis(methylene)) bis(oxy))diisophthalic acid (H4L) and its utilization to synthesize a new Cu-MOF (IITI-3). IITI-3 crystallizes in a tetragonal crystal system with space group I4/mmm and shows a high surface area of 1026.5 m2/g with a pore diameter of 3.413 nm. The IITI-3 is found to be stable in the pH range from 3-10 and in cell culture media. The hemocompatibility and biocompatibility studies were performed for use as a drug delivery system. Furthermore, the IITI-3 was encapsulated with insulin (insIITI-3) and modified with gelatin (gel@insIITI-3) and explored. Insulin loading of 20 wt% was obtained within 1 h. A drug release study reveals that gel@insIITI-3 has a controlled release with respect to insIITI-3, which is well suited with commercial Hum-insulin and maintains its activity. Thus, based on the release performance, good biocompatibility, hemocompatibility, and presence of gelatin coating, we believe that gel@insIITI-3 may be a potential candidate for an exciting possibility in the areas of protein and nucleic acid-based oral delivery and can be extended further for other diseases in the future. References 1. P. Kumar, N. Kaur, P. Tiwari, A. K. Gupta and S. M. Mobin, ACS Materials Lett. , 2023, 5 , 1100–1108.
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