Fabrication of hybrid polycaprolactone nanofibers enriched with curcumin, zinc oxide and titanium dioxide nanoparticles for wound dressing applications Yeong Han Lee 1 , Yun Khoon Liew 2 , Wei Meng Lim 3 , Lai Chun Wong 4 , Yoon Yee Then 4 1 School of Postgraduate Studies, International Medical University, Malaysia, 2 Department of Life Sciences, International Medical University, Malaysia, 3 School of Pharmacy, Monash University Malaysia, 4 Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Malaysia Curcumin is a naturally occurring substance that has been used therapeutically in various regions of the world for centuries. However, it has various drawbacks that limit its bioactivity, including limited bioavailability, water insolubility, chemical instability, and extensive metabolism. In an effort to overcome these restrictions, the electrospinning method was employed to generate nanofibers made of polycaprolactone (PCL), curcumin (Cur), titanium dioxide (TiO 2 ), and zinc oxide (ZnO) in this study. The resultant nanofibers possessed randomly oriented, spherical fibres that were devoid of flaws and had a restricted size distribution. The release of curcumin was investigated, and the shape and physical properties of nanofibers were compared to those of pristine PCL. In addition, the antibacterial and antibiofilm abilities of the nanofibers were assessed against two typically linked opportunistic pathogens, Pseudomonas aeruginosa and Streptococcus aureus . The Cur/TiO 2 /ZnO- loaded PCL nanofibers suppressed the formation and activity of biofilms related to both P. aeruginosa and S. aureus , demonstrating their promise as a solution for reducing biofilm-associated infections. Due to their great biocompatibility, the produced nanofibers could also be used as scaffolds in tissue engineering regeneration, accelerating the healing process. This study gives important insights into the usage of Cur/TiO 2 /ZnO-loaded PCL nanofibers to solve the limitations of curcumin in medicinal formulations.
P42
© The Author(s), 2023
Made with FlippingBook Learn more on our blog