An evaluation of antimicrobial potency of silver nanoparticles synthesised from Fusarium sp. Vincent Mwangi 1 , Edwin Madivoli 1 , Mourine Kangogo 2 , Sammy Wanakai 1 , Dennis Nzilu 1, Walyambillah Waudo 1 1 Chemistry Department, Jomo Kenyatta University of Agriculture and Technology, Kenya, 2 Medical Microbiology Department, Jomo Kenyatta University of Agriculture and Technology, Kenya Today in the world antimicrobial resistance has proved to be among the major and urgent risks to human health which make prevention and successful treatment of persistent diseases difficult. Frequent misuse and overuse of medications in the health sector largely contribute to the emergence of the resistance. In the efforts of finding alternatives to antimicrobials that develop resistance, biological synthesis of metal nanoparticles have caught the interest of scientists due to the environment friendly synthesis approach which yields metallic nanoparticles with antimicrobial potency. In the present study silver nanoparticles were produced with the assistance of Fusarium sp . fungal cell filtrate and their antimicrobial potency was explored. The silver nanoparticles depicted a surface plasma resonance of 434 nm when run in the UV-VIS spectrophotometer. The functional group present in the nanoparticles were investigated using an Attenuated Total Reflectance-Fourier transform infrared where functional groups associated with the coenzyme NADPH were notable. The morphology and crystallinity of the produced silver nanoparticles was investigated with the help of a Scanning Electron Microscope and X-ray Diffraction respectively. The results revealed that the nanoparticles were crystalline with a face centred cubic structure, the nanoparticles were also found were to be spherical with sizes ranging from 3 nm to 30 nm. Antimicrobial studies showed that the synthesised silver nanoparticles had promising activities against disease causing microorganisms Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. References 1. Aguilar, G. R., et al . ( 2023 ). Articles The burden of antimicrobial resistance in the Americas in 2019 : a cross-country systematic analysis. The Lancet Regional Health - Americas , 1–16. https://doi.org/10.1016/j.lana.2023.100561 2. Ahmad, M., & Khan, A. U. ( 2019 ). Global economic impact of antibiotic resistance: A review. Journal of Global Antimicrobial Resistance , 19 , 313–316. https://doi.org/10.1016/j.jgar.2019.05.024 3. Guilger-Casagrande, M., & Lima, R. de . ( 2019 ). Synthesis of Silver Nanoparticles Mediated by Fungi: A Review. Frontiers in Bioengineering and Biotechnology , 7 , 1–16. https://doi.org/10.3389/fbioe.2019.00287
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