Synthesis, characterization and medicinal applications of 3-hydrazino-1,2,4-triazino-[5,6-b] indole derivatives Samina Aslam 1 , Sadia Rani 2 1 The Women University Multan, Pakistan, 2 Department of Chemistry The Women University Multan, Pakistan 1,2,4-triazino[5,6-b]indole derivatives have variety of pharmacological activities and extensively used for the treatment of different disease.This project's purpose is to develop biologically active 1,2,4-triazino[5,6-b]indole derivatives. 3H-1,2,4-triazino [5,6-b] indole-3-thione variants were made by fusing equimolar concentrations of isatin-analogues and thiosemicarbazides in the presence of K 2 CO 3 , while 3-Hydrazino-1,2,4-triazino [5,6-b] indole derivatives were prepared using an equimolar mixture of and hydrazine hydrate. A succession of hydrazones was practiced by condensation of different aromatic aldehydes with by refluxing in Ethanol. The synthesized compounds were characterized by different analytical techniques and tested for antioxidant and antidiabetic activities.. References 1. A.-Mohsen M. E. Omar*, N. H. E. and H. M. A. (1981). Synthesis, 13C-NMR Characterization and Antimicrobial Properties of a Novel Series of 3-(N-Substituted thiocarbamoyl)hydrazino-1,2,4-triazino- [5,6-b]indole Derivatives. Journal of Chemical Information and Modeling , 53 (9), 1689–1699. 2. Abdel-Rahman, R. M. (1991). Synthesis and anti human immune virus activity of some new fluorine containing substituted- 3-thioxo-1,2,4-triazin-5-ones. Farmaco , 46 (2). 3. Ahmed Mousaad, Hamida Abdel Hamida, Ahmed El Nemr, E. S. H. E. ashry. (1992). Synthesis of 3-(Alditol-1-yl) triazolo[4’,3’:2,3]-1,2,4-trizino[5,6-b]indole (pp. 546–552). 4. Ali, R. S., Al Harthi, R. R., Saad, H. A., & Amin, M. A. (2016). Synthesis of some new fused 1,2,4-triazines and their antimicrobial activity. Russian Journal of General Chemistry , 86 (12), 2906–2913. https://doi.org/10.1134/ S1070363216120598 5. Ali, R. S., & Saad, H. A. (2018). Synthesis of some novel fused pyrimido[4″, 5″:5′, 6′]- [1, 2, 4]triazino[3′, 4′:3, 4] [1, 2, 4] triazino[5, 6-b]indoles with expected anticancer activity. Molecules , 23 (3). https://doi.org/10.3390/molecules23030693 6. Aswar, U. M., Kalshetti, P. P., Shelke, S. M., Bhosale, S. H., & Bodhankar, S. L. (2012). Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats. Asian Pacific Journal of Tropical Biomedicine , 2 (12), 992–998. https://doi.org/10.1016/S2221-1691(13)60012-X
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