Multicomponent reactions: a green tool in the hands of the synthetic chemist Roderick Abdilla University of Malta, Malta Among all the tools available in the hands of the organic chemist to render synthetic processes more economically and environmentally feasible and sustainable, there lies a gem in the form of multicomponent reactions (MCRs). Essentially, MCRs allow the combination of three or more different reactants in the same flask (one-pot) to generate complex products that usually cannot be formed in an otherwise conventional step-wise fashion. 1 Our research group combines this concept with the use of cheap and easily-synthesizable heterogeneous catalysts so as to be able to recover and reuse them in subsequent runs of the same MCR type.[2,3] Recently, our group has also ventured into the development of four and five-component reactions as well as MCRs which use the product of another MCR-type as one of its starting materials. References 1. Singh, M. S.; Chowdhury, S. Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco- compatible organic synthesis. RSC Adv. 2012, 2, 4547 -4592. 2. Bosica, G. Heterogeneous Catalysis. In Sustainable organic synthesis: Tools and strategies, Protti, S., Palmieri, A., Eds.; Royal Society of Chemistry: London, 2021; Chapter 3, pp. 45-67. 3. Bosica, G. Abdilla, R. Recent advances in multicomponent reactions under operationally heterogeneous conditions. Catalysts 2022, 12(7), 725-754.
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