Synthesis, spectral, antimicrobial investigation of piperazine- 1,4-diium based two nitrogen containing organic complexes with biphenyl-4,4'-bis(olate) Karunanithi Suganya , Dhurairaj Satheesh*, Sundaram Manjunathan PG and Research Department of Chemistry, Loganatha Narayanaswamy Government College (Autonomous), Tamilnadu, India. In this present investigatio, new diprotic piperazinium based nitrogen containing two organic complexes, namely Piperazine-1,4-diium biphenyl-4,4'-bis(olate) ( PDBP-4,4'-BO ) and (2R,5S)-2,5-dimethylpiperazine-1,4- diiumbiphenyl-4,4'-bis(olate) ( 2,5-DMPDBP-4,4'-BO ) were synthesized through the simple proton transfer reaction between Piperazine and Biphenyl-4,4'-diol ( BPD ) by strring method at room temperature. After completion of proton transfer, two orgnic complexes PDBP-4,4'-BO and 2,5-DMPDBP-4,4'-BO were achieved with an excellent yield. The synthesized diprotic piperazinium complexes PDBP-4,4'-BO and 2,5-DMPDBP-4,4'-BO were characterized successfully and their formation were confirmed by analytical (Colour, physical state and elemental analysis) and spectral studies such as FT-IR, 1 H and 13 C NMR spectroscopy techniques. This methodology involves simple procedure, room temperature reaction and environmentally friendly conditions. The PDBP-4,4'- BO and 2,5-DMPDBP-4,4'-BO were screened to their antibacterial ( Staphylococcus aureus, Enterococcus sp, Escherichia coli and Klebsiella pneumoniae ) and antifungal ( Candida albicans ) activities. The standard drugs, Nalixidix acid, Chloramphenicol and Fluconazol were used for this study against gram-positive, gram-negative bacteria and fungi respectively. The standard drugs were used in this study, they were not shown antibacterial and antifungal activity in all the tested concentrations. The PDBP-4,4'-BO has been shown an excellent antibacterial and antifungal activity compared to the tested 2,5-DMPDBP-4,4'-BO and their corresponding standard drugs ( Nalixidix acid, Chloramphenicol ). The 2,5-DMPDBP-4,4'-BO was shown an excellent activity compared to PDBP- 4,4'-BO and standard drug ( Fluconazol ). References 1. D. Satheesh et al., Chemical Data Collections 28 ( 2020 ) 100406; 2. Results in Chemistry 2 ( 2020 ) 100033; 3. Chemical Data Collections. 33 ( 2021 ) 100726.
4. N. Afsar et al., Journal of Molecular Structure. 2021; 1244; 130967; 5. Journal of the Indian Chemical Society. 2022; 99(9); 100655.
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