CN April May 2023 Vol. 62 Issue 3

A NEW ALTERNATIVE IN ANTIBIOTIC TREATMENT Norbrook Introduces Tulieve By Patti Wilson Contributing Editor SPECIAL FEATURE

Each mL contains 300 mg of oxytetracycline base (equivalent to 323.5 mg of oxytetracycline dihydrate). For Use in Beef Cattle, Non-lactating Dairy Cattle, Calves, Including pre-ruminating (veal) calves (oxytetracycline injection) ANTIBIOTIC Noromycin ® 300 LA Approved by FDA under NADA # 141-143

MORE HEAD TREATED PER BOTTLE * 33% ]

C attlemen have another tool in the box for treatment against a broad spectrum of bacterial pathogens. Dr. Eric Moore, Director of Technical Services for Norbrook, spoke with me at length about their new product, Tulieve. It is a macrolide, meaning an antibacterial that inhibits protein synthesis in both gram-positive and gram-negative bacteria. Tulieve is proven effective in treatment of many respiratory diseases in cattle. He described the drug as being administered in a low-dose, single injection. It is long lasting, readily absorbed and has an 18-day withdrawal. Keeping All the Bases Covered With the addition of Tulieve, Norbrook now has five classes of antibiotics available to cattle producers. Tulieve comes with several advantages. It is packaged in plastic bottle, greatly reducing the possibility of breakage. It comes in four options: Exclusive (one liter), 500 mL (both come in hanger bottles), 250 mL and 100 mL. It is the only generic tulathromycin that is available in plastic. Some Good Advice Moore offered some very sound council during our visit. He said the No. 1 priority for every cattleman and for Norbrook is to prevent the need for antibiotics. The second is to provide effective antibiotics when needed. A great piece of advice was to develop a comprehensive preventative program. Gather as much information about the vaccines available and seek guidance from your animal health professional to assure you are implementing the best program available. This will assure that the products purchased are compatible

to help avoid unpleasant repercussions from using vaccines that are not made for simultaneous administration. Norbrook manufactures only FDA- approved products (antibiotics, anti- parasiticides and anti-inflammatories) and does not make vaccines. It has no conflict with any companies who provide vaccines or vaccination programs. He also recommends uncoupling your prevention and treatment programs; if you have a good disease-prevention program, you shouldn’t need to bundle you treatment program with it. Moore described Norbrook’s products as “generic.” The product line is packaged more conveniently and is more affordable than the original antibiotics. He reminds us that there are no new classes of antimicrobials coming down the line. Norbrook, carrying all five classes available, can provide all your drug needs as well as competent representatives to advise as needed. Moore’s final thought was that Norbrook will continue to bring products that are useful to producers and the industry.

BRIEF SUMMARY (For full Prescribing Information, see package insert.)

INDICATIONS: NOROMYCIN 300 LA is intended for use in treatment for the following diseases when due to oxytetracycline-susceptible organisms: Beef cattle, non-lactating dairy cattle, calves, including pre-ruminating (veal) calves: NOROMYCIN 300 LA is indicated in the treatment of pneumonia and shipping fever complex associated with Pasteurella spp., and Histophilus spp. NOROMYCIN 300 LA is indicated for the treatment of infectious bovine keratoconjunctivitis (pink eye) caused by Moraxella bovis, foot-rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis Swine: NOROMYCIN 300 LA is indicated in the treatment of bacterial enteritis (scours, colibacillosis) caused by Escherichia coli; pneumonia caused by Pasteurella multocida; and leptospirosis caused by Leptospira pomona. In sows NOROMYCIN 300 LA is indicated as an aid in control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli. PRECAUTIONS: Exceeding the highest recommended level of drug per pound of bodyweight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site in adult beef cattle and non-lactating dairy cattle and 5 mL intramuscularly per injection site in adult swine, may result in antibiotic residues beyond the withdrawal time. Consult with your veterinarian prior to administering this product in order to determine the proper treatment required in the event of an adverse reaction. At the first sign of any adverse reaction, discontinue use of the product and seek the advice of your veterinarian. Some of the reactions may be attributable either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause. caused by strains of staphylococcal and streptococcal organisms sensitive to oxytetracycline. Shortly after injection treated animals may have transient hemoglobinuria resulting in darkened urine. As with all antibiotic preparations, use of this drug may result in overgrowth of non-susceptible organisms, including fungi. The absence of a favorable response following treatment, or the development of new signs or symptoms may suggest an overgrowth of non-susceptible organisms. If superinfections occur, the use of this product should be discontinued and appropriate specific therapy should be instituted. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving NOROMYCIN 300 LA in conjunction with penicillin.

With its 33% lower volume dose per injection, *compared to 200 mg/mL oxytetracycline injectables, Noromycin® 300 LA (oxytetracycline 300 mg/mL) is your effective, broad-spectrum and economical antibiotic for seasonal diseases in beef cattle, non-lactating dairy cattle and swine. Stop by your local animal health provider or visit norbrook.com. It pays to compare labels when treating seasonal diseases in cattle.

WARNINGS:

Warnings: Discontinue treatment at least 28 days prior to slaughter of cattle and swine. Not for use in lactating dairy animals. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. CAUTION: Intramuscular or subcutaneous injection may result in local tissue reactions which persists beyond the slaughter withdrawal period. This may result in trim loss of edible tissue at slaughter. Intramuscular injection in the rump area may cause mild temporary lameness associated with swelling at the injection site. Subcutaneous injection in the neck area may cause swelling at the injection site. ADVERSE REACTIONS: Reports of adverse reactions associated with oxytetracycline administration include injection site swelling, restlessness, ataxia, trembling, swelling of eyelids, ears, muzzle, anus and vulva (or scrotum and sheath in males), respiratory abnormalities (labored breathing), frothing at the mouth, collapse and possibly death. Some of these reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause. To report a suspected adverse reaction call 1-866-591-5777. Livestock Drug - Not for Human Use. Restricted Drug(s) California. Use Only as Directed.

PREPARE FOR THE PRESCRIPTION-ONLY STATUS COMING SOON. SET A PLAN IN PLACE NOW TO ENSURE CONTINUED ACCESS TO NOROMYCIN® 300 LA.

Manufactured by: Norbrook, Inc. Lenexa, KS 66219

Observe label directions and withdrawal times. Not for use in lactating dairy animals. Adverse reactions, including injection site swelling, restlessness, ataxia, trembling, respiratory abnormalities (labored breathing), collapse and possibly death have been reported. See product labeling for full product information.

Eric Moore, DVM

MADE IN THE UK

Rev: August 2021 Version: I08

1222-143-I08A

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