Contact Information: Contact Name: Agnieszka Janeczek E-mail: agnieszka.janeczek@renovos.co.uk Website: www.renovos.co.uk Funding required: £4,000,000 (£1,5000,000 already secured in non-dilutive funding) Renovos is pioneering its synthetic nanoclay gels, RENOVITE®, for therapeutics delivery in regenerative medicine, for a safe and precise tissue regeneration. The Problem The use of biologics in tissue regeneration can lead to adverse events due to their poor localisation. For example, FDA banned BMP2 protein use from cervical spine procedures due to safety issues. Complications from current interventions can include chronic pain, nerve damage and bone forming outside of the skeleton, which result in substantial patient burden, as well as an economic burden to healthcare systems. Yet in many cases, BMP2 remains the only reliable option for promoting bone tissue formation.
The Solution RENOVITE® nanoclay gel is an injectable and biodegradable material that offers precise delivery and unprecedented RETENTION of therapeutics (biologics, drugs, cells) within the target site of repair, taming them. This allows for significant dose reduction, lower cost of goods sold and improved safety. The social impact of effective bone treatments, through delivering safe and easy-to-use bone forming materials, for keeping the globally increasing ageing population healthy, active and in work for longer cannot be overstated. This combination of increasing efficacy, with improved safety, cuts across orthopaedics and allows the creation of a platform drug-delivery technology. It has the potential to address the unmet need for long term tissue regeneration, offering safer, more economic clinical solutions for health systems and better outcomes for patients. Nanoclays are industrial ingredients, used as rheology modifiers. Renovos has adapted this technology, and is pioneering the use of synthetic nanoclay gels for medical applications in regenerative medicine, with its proprietary formulations. In addition to providing unprecedented retention of therapeutic agents, RENOVITE® is a sustainable, low-cost, synthetic material which can be easily scaled up (produced in tonnes at an industrial scale) with minimal need for hazardous chemicals and with minimal impact on the environment, by comparison to approaches relying on animal-sourced components and/or complex polymer chemistries.
Made with FlippingBook Learn more on our blog