NEWLY DIAGNOSED PROSTATE CANCER GUIDE
Prostate Cancer Progression and Treatment Prostate cancer can be diagnosed at various stages, depending on when the prostate cancer is detected and how far the disease has progressed. Many patients respond immediately to treatment and don’t require any further treatment. Others may already have metastatic disease by the time the cancer is first diagnosed or later develop metastatic disease after treatment completion for early-stage disease. Treatment to lower testosterone is a mainstay of therapy for patients with metastatic disease. When prostate cancer becomes resistant to this type of therapy it is called hormone or castrate resistant. The definitions and ways prostate cancer can progress may be confusing, but here is a chart to help you:
Prostate Cancer and Treatment Progression
Targeted Therapy, Chemotherapy, Immunotherapy
Radiation, Surgery
Novel Antiandrogens, Chemotherapy
Hormone Therapy
Clinical Trials
Non-Metastatic Prostate Cancer
Metastatic Prostate Cancer
Hormone-Sensitive Prostate Cancer (HSPC)
Hormone-Resistant Prostate Cancer (HRPC)
Hormone-Sensitive Prostate Cancer (HSPC, also called Castration-Sensitive Prostate Cancer or CSPC) This is a form of prostate cancer that still responds to testosterone suppression therapy. HSPC can be referred to as non-metastatic, or nmHSPC, when there is no detectable metastases - spread of cancer - upon imaging. It can be referred to as mHSPC when it has advanced to metastatic stage. Hormone-Resistant Prostate Cancer (HRPC, also called Castration-Resistant Prostate Cancer or CRPC) This is a form of prostate cancer that keeps growing even when the amount of testosterone in the body is reduced to very low levels. HRPC can be referred to as non-metastatic, or nmHRPC, when there is no detectable metastases upon imaging, and as mHRPC when it has advanced to metastatic stage. Before deciding on a treatment with your doctor, learning about all treatment options, as well as clinical trials, is important. Treatment decisions should be based on many factors, including your age, overall health, family history, stage at diagnosis, aggressiveness of the disease, and results of genetic testing, among others. In addition, understanding possible side effects of each treatment, how side effects can be managed, weighing quality of life issues, and deciding what is most important to you and your family should all be considered. Learn more at zerocancer.org/treatment-options .
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