Boehringer Ingelheim VPH TADtalk Global Newsletter Issue 2

FMDV 1. An innovative immunochromatographic assay employing Pt-Pd bimetallic nanoparticles as labels for the detection of foot-and-mouth disease virus serotype O. Link 2. Porcine interferon- α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against the foot-and-mouth disease virus. Link 3. Adoption of veterinary vaccines, determining factors, and barriers in Southwest Ethiopia: implications for livestock health and disease management strategies. Link

13. A novel immunoinformatics approach for developing a poly-epitope vaccine targeting foot and mouth disease virus, exploiting structural VP proteins. Link 14. Biological properties of strain A 2205/G-IV foot and mouth disease virus [in Russian, google- translated]. Link 15. Determination of Optimal Antigen Yield and Virus Inactivation Conditions for the Production of the Candidate Foot-and-Mouth Disease Recombinant Vaccine Strain Asia1 Shamir-R in a Bioreactor. Link 16. Strategies for Transboundary Swine Disease Management in Asian Islands: Foot and Mouth Disease, Classical Swine Fever, and African Swine Fever in Taiwan, Japan, and the Philippines. Link

4. Determinants and Control Strategies of FMD in Japan and Indonesia

5. Intradermal Inoculation of Inactivated Foot- and-Mouth Disease Vaccine Induced Effective Immune Responses Comparable to Conventional Intramuscular Injection in Pigs. Link 6. Evaluation of Foot-and-Mouth Disease (FMD) Virus Asia1 Genotype-V as an FMD Vaccine Candidate: Study on Vaccine Antigen Production Yield and Inactivation Kinetics. Link 7. Calcium Chloride Treatment Enhances Antigen Production in Foot-and-Mouth Disease Vaccines for Serotypes SAT1 and SAT3. Link

17. Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus. Link

18. Evaluation of Two Vaccines against Foot- and-Mouth Disease Used in Transcaucasian Countries by Small-Scale Immunogenicity Studies Conducted in Georgia, Azerbaijan and Armenia. Link 19. Foot-and-Mouth Virus Capsid Protein VP1 Antagonizes Type I Interferon Signaling via Degradation of Histone Deacetylase 5. Link 20. Calcium Chloride as a Novel Stabilizer for Foot- and-Mouth Disease Virus and Its Application in the Vaccine Formulation. Link 21. Cell Culture Adaptive Amino Acid Substitutions in FMDV Structural Proteins: A Key Mechanism for Altered Receptor Tropism. Link 22. Prophylactic treatment with PEGylated bovine IFN λ 3 effectively bridges the gap in vaccine- induced immunity against FMD in cattle. Link 23. Seroprevalence and molecular detection of foot and mouth disease virus in cattle in selected districts of Wolaita Zone, Southern Ethiopia. Link 24. Postvaccination serosurveillance of foot-and- mouth disease through virus-neutralizing and nonstructural protein antibody tests on pig farms in Taiwan: 2009–2020. Link

8. Foot-and-mouth disease virus dynamics in border areas of Pakistan with Afghanistan. Link

9. Isoprinosine as a foot-and-mouth disease vaccine adjuvant elicits robust host defense against viral infection through immunomodulation. Link 10. Spatial and temporal distribution of foot-and- mouth disease outbreaks in Algeria from 2014 to 2022. Link 11. The dual role of a highly structured RNA (the S fragment) in the replication of foot-and-mouth disease virus. 12. In-process quality control in foot-and-mouth disease vaccine production by detection of viral non-structural proteins using chemiluminescence dot blot assay. Link

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