How EMPAVELI can help | TRANSFUSIONS AND ARC
Avoiding the need for transfusions with EMPAVELI
Becoming transfusion-free with EMPAVELI vs eculizumab— in people who had previously received a C5i At Week 16 in PEGASUS, EMPAVELI was no worse than a C5i (eculizumab) in helping people with PNH become transfusion-free.
In people who had previously received a C5i (PEGASUS)
“I have not needed a transfusion since I switched to EMPAVELI.” Individual experiences may vary.
Jillian is an adult with PNH who's taken EMPAVELI.
of people taking EMPAVELI were transfusion-free
of people taking a C5i (eculizumab) were transfusion-free
Becoming transfusion-free with EMPAVELI vs control arm— in people who had never received a complement inhibitor At Week 26 in PRINCE, most people taking EMPAVELI were transfusion-free.
In people who had previously received a C5i (PEGASUS)
Average changes in ARC with EMPAVELI vs eculizumab— in people who had previously received a C5i People taking EMPAVELI saw their ARC reduced by 136 x 10 9 cells/L People taking a C5i (eculizumab) saw an increase in their ARC of 28 x 10 9 cells/L Reduced ARC At Week 16 in PEGASUS, EMPAVELI was no worse than a C5i (eculizumab) in helping people with PNH reduce their ARC.
In people who had never received a complement inhibitor (PRINCE)
of people taking EMPAVELI were transfusion-free
of people in the control arm (excluding complement inhibitors) were transfusion-free
IMPORTANT SAFETY INFORMATION (cont’d) Tell your healthcare provider about all the vaccines you receive and medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements which could affect your treatment.
ARC=absolute reticulocyte count; C5i=C5 inhibitor; PNH=paroxysmal nocturnal hemoglobinuria.
Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.
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