How EMPAVELI can help | FATIGUE
A post hoc analysis of PEGASUS data found a link between Hb and fatigue
“I love leisurely walks and vacations with my family. With my increase in Hb levels and energy, I don’t have to miss out. ” Individual experiences may vary.
In people who had previously received a C5i (PEGASUS)
10 12 14
2 4 6 8
Andrea is an adult with PNH who's taken EMPAVELI.
People with greater improvements in Hb showed larger reductions in fatigue
11.3
-1.2
9.9
0 -2 -4
<1.0 g/dL n=39
Increase in Hb ≥1.0-<2.0 g/dL n=8
≥2.0 g/dL n=25
People with PNH who had an Hb improvement of 1 g/dL or more had an average fatigue improvement of ~10 points .
A post hoc analysis gathers additional findings after a study has ended. It is not considered as scientifically strong as an analysis that was planned before the study began This analysis included people receiving EMPAVELI and people receiving eculizumab C5i=C5 inhibitor; FACIT=Functional Assessment of Chronic Illness Therapy; Hb=hemoglobin; PNH=paroxysmal nocturnal hemoglobinuria. Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.
IMPORTANT SAFETY INFORMATION (cont’d) What are the possible side effects of EMPAVELI? (cont'd)
The most common side effects in people with PNH treated with EMPAVELI include injection-site reactions; infections; diarrhea; pain in the stomach (abdomen); respiratory tract infection; pain in the arms, hands, legs, or feet; low potassium in blood; tiredness; viral infection; cough; joint pain; dizziness; headache; and rash.
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