Where will you go next?

If you're like Angelo, an adult with PNH taking EMPAVELI,

Talk to your doctor about whether EMPAVELI is right for you.

see what's possible with EMPAVELI

connect with someone taking EMPAVELI

PNH=paroxysmal nocturnal hemoglobinuria .

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide. EMPAVELI may also increase the risk of getting serious infections caused by certain bacteria such as Streptococcus pneumoniae, Neisseria meningitidis , and Haemophilus influenzae type B. Serious infections may quickly become life-threatening and cause death if not recognized and treated early. 1. Y ou must be vaccinated against these bacteria at least 2 weeks before your first dose of EMPAVELI if you have not already had these vaccines. INDICATION AND IMPORTANT SAFETY INFORMATION What is EMPAVELI ® (pegcetacoplan)? EMPAVELI is a prescription medicine used to treat adults with a disease called paroxysmal nocturnal hemoglobinuria (PNH). What is the most important information I should know about EMPAVELI? EMPAVELI is a medicine that can affect your immune system and can lower the ability of your immune system to fight infections. EMPAVELI may increase your chance of getting serious and life-threatening meningococcal infections that may quickly become life-threatening and cause death if not recognized and treated early.

Table of Contents

Hemolysis in PNH

4 6 8

[gl ow -bin] verb; Acting in pursuit of higher hemoglobin levels

How EMPAVELI works

Why EMPAVELI

Globin’ can correlate to higher levels of hemoglobin in your blood. Hemoglobin carries oxygen throughout your body—and oxygen is, you know, the stuff of life.

How EMPAVELI can help

Possible side effects

discover how you can be Globin’

Self-administering EMPAVELI

28 32 35 36 38 40

ApellisAssist ® program

Helpful resources and tools

PNH Peer 2 Peer program

Important Safety Information

Glossary

IMPORTANT SAFETY INFORMATION (cont’d) What is the most important information I should know about EMPAVELI? (cont'd) 2. If your healthcare provider decides that urgent treatment with EMPAVELI is needed, you should receive the required vaccinations as soon as possible. 3. If you have not been vaccinated and EMPAVELI therapy must be initiated immediately, you should also receive 2 weeks of antibiotics with your vaccinations. 4. If you have been vaccinated against these bacteria in the past, you might need additional vaccinations before starting EMPAVELI. Your healthcare provider will decide if you need additional vaccinations.

PNH=paroxysmal nocturnal hemoglobinuria .

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

Hemolysis in PNH

With C5i treatments, some people with PNH may continue to have symptoms According to this survey, some people continued to have low Hb levels, ongoing fatigue, and the need for transfusions.

The impact of hemolysis in PNH Ongoing hemolysis may be causing your PNH symptoms

This could mean hemolysis is not under control.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disease that involves the body’s immune system acting irregularly. In PNH, the immune system attacks and destroys its own red blood cells in a process called hemolysis. If hemolysis is not addressed, it can cause lower than normal levels of red blood cells and hemoglobin (Hb) in your blood. This may cause ongoing PNH symptoms, like fatigue, that force you to make compromises in your daily life.

In this survey, people reported:

Not achieving Hb levels ≥10.5 g/dL *

on eculizumab (20/32)

on ravulizumab (47/82)

Ongoing fatigue †

Also, with anemia caused by low Hb levels, people with PNH may need to get frequent transfusions, which can take a toll on the body over time.

on eculizumab (31/35)

on ravulizumab (65/87)

Ongoing need for transfusions ‡

on eculizumab (12/23)

on ravulizumab (7/31)

• 122 people taking a C5i treatment for their PNH were surveyed (35 received eculizumab, 87 received ravulizumab) • Most people surveyed (97%) had been taking C5i treatment for ≥3 months Possible limitations of the survey • A small number of people surveyed • People not satisfied with their current C5i treatment may have been more motivated to participate • Responses being subjective due to how people interpreted and reported their experiences • The results cannot be generalized to all people with PNH Findings from a US survey of people with PNH taking C5i treatment

C5i=C5 inhibitor.

‡ In patients who had a lifetime history of a transfusion and were on C5i treatment for at least 1 year. The need for transfusions was defined as 1 or more transfusions in the past 12 months. † Fatigue was measured using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale, which is a type of survey that collects information about the impact of fatigue on different parts of daily life. The scale ranges from 0 to 52. Higher scores mean less fatigue. * Based on responses from 114 of the 122 survey participants who reported their Hb levels.

Don't delay! Talk to your healthcare provider about your ongoing PNH symptoms and available treatment options.

How EMPAVELI works

How EMPAVELI works in PNH

EMPAVELI is the first and only treatment for PNH that controls both types of hemolysis

EMPAVELI acts differently than other PNH treatments EMPAVELI works higher in the complement system than C5i treatments

intravascular hemolysis (IVH)

extravascular hemolysis (EVH)

The complement system is a part of your immune system and helps the body fight off infections. Certain proteins in the complement system work together and create a chain reaction. This chain reaction is called the complement cascade.

IMPORTANT SAFETY INFORMATION (cont’d) What is the most important information I should know about EMPAVELI? (cont'd)

5. Vaccines reduce the risk of serious infections, but do not prevent all serious infections. Call your healthcare provider or get emergency medical care right away if you get any of these signs and symptoms of a serious infection: fever with or without shivers or the chills fever and a rash shortness of breath extreme pain or discomfort headache with nausea or vomiting high heart rate headache and a fever headache with a stiff neck or stiff back confusion muscle aches with flu-like symptoms clammy skin eyes sensitive to light

PNH=paroxysmal nocturnal hemoglobinuria.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

Why EMPAVELI

What is EMPAVELI? Discover what’s possible with EMPAVELI EMPAVELI is a prescription medicine used to treat adults with paroxysmal nocturnal hemoglobinuria (PNH).

EMPAVELI was studied in two Phase 3 clinical trials to find out how effective and safe EMPAVELI is in treating PNH:

Previous C5i treatment (PEGASUS) Compared EMPAVELI to a C5i treatment (eculizumab) in 80 adults with PNH who had previously received a C5i

No previous C5i treatment (PRINCE) Compared EMPAVELI to a control arm* (without EMPAVELI or C5i treatment) in 53 adults with PNH who had never received a C5i

See how EMPAVELI was studied in PRINCE

See how EMPAVELI was studied in PEGASUS

*People in the control arm could continue taking stable doses of their medications for PNH except for EMPAVELI or C5i treatments (like eculizumab or ravulizumab).

IMPORTANT SAFETY INFORMATION (cont’d) What is the most important information I should know about EMPAVELI? (cont'd) Your healthcare provider will give you a Patient Safety Card about the risk of serious infections. Carry it with you at all times during treatment and for 2 months after your last EMPAVELI dose. It is important to show this card to any healthcare provider to help them diagnose and treat you quickly. EMPAVELI is only available through a program called the EMPAVELI Risk Evaluation and Mitigation Strategy (REMS). Before you can take EMPAVELI, your healthcare provider must enroll in the EMPAVELI REMS program, counsel you about the risk of serious infections caused by certain bacteria, give you information about the symptoms of serious infections, give you a Patient Safety Card about your risk of serious infections, and make sure that you are vaccinated.

Monica is an adult with PNH taking EMPAVELI.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

How EMPAVELI can help | HEMOGLOBIN

Increased hemoglobin with EMPAVELI

Superior improvements in hemoglobin (Hb) in people who had previously received a C5i: results at Week 16 Primary goal in the PEGASUS study: to explore whether EMPAVELI was better at improving Hb levels than a C5i (eculizumab) in people living with paroxysmal nocturnal hemoglobinuria (PNH)

Peg is an adult with PNH taking EMPAVELI.

In people who had previously received a C5i (PEGASUS)

Hb improvement was maintained through the 48-week study

People taking EMPAVELI had a 2.37 g/dL Hb INCREASE

SUPERIOR Hb DIFFERENCE of 3.84 g/dL with EMPAVELI compared to eculizumab ( P <0.0001)

Average change in Hb levels from beginning to Week 48

People taking eculizumab had a 1.47 g/dL Hb DECREASE

View graph of Hb improvement over 16 weeks

IMPORTANT SAFETY INFORMATION (cont’d) Who should NOT take EMPAVELI? Do not take EMPAVELI if you: are allergic to pegcetacoplan or any of the ingredients in EMPAVELI.

C5i=C5 inhibitor; EMP=EMPAVELI; OLP=open-label period; RCP=randomized control period; SE=standard error.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

How EMPAVELI can help | HEMOGLOBIN

Stabilized hemoglobin (Hb) levels in people who had never received a C5i: results at Week 26* Stabilized hemoglobin with EMPAVELI

In people who had never received a C5i (PRINCE)

86%

Stacey is an adult with PNH taking EMPAVELI.

of people taking EMPAVELI achieved Hb stabilization over 26 weeks

IMPORTANT SAFETY INFORMATION (cont’d) Before you take EMPAVELI, tell your healthcare provider about all of your medical

*Hb stabilization means avoiding a >1 g/dL decrease in Hb levels throughout the study.

conditions, including if you: have an infection or fever.

are pregnant or plan to become pregnant. EMPAVELI may harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with EMPAVELI and use an effective method of birth control during treatment with EMPAVELI and for 40 days after the last dose. are breastfeeding or plan to breastfeed. It is not known if EMPAVELI passes into your breast milk. You should not breastfeed during treatment with EMPAVELI and for 40 days after the last dose.

C5i=C5 inhibitor; PNH=paroxysmal nocturnal hemoglobinuria.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

How EMPAVELI can help | TRANSFUSIONS AND ARC

Avoiding the need for transfusions with EMPAVELI

Becoming transfusion-free with EMPAVELI vs eculizumab— in people who had previously received a C5i At Week 16 in PEGASUS, EMPAVELI was no worse than a C5i (eculizumab) in helping people with PNH become transfusion-free.

In people who had previously received a C5i (PEGASUS)

“I have not needed a transfusion since I switched to EMPAVELI.” Individual experiences may vary.

Jillian is an adult with PNH taking EMPAVELI.

of people taking EMPAVELI were transfusion-free

of people taking a C5i (eculizumab) were transfusion-free

Becoming transfusion-free with EMPAVELI vs control arm— in people who had never received a C5i At Week 26 in PRINCE, most people taking EMPAVELI were transfusion-free.

In people who had previously received a C5i (PEGASUS)

Average changes in ARC with EMPAVELI vs eculizumab— in people who had previously received a C5i People taking EMPAVELI saw their ARC reduced by 136 x 10 9 cells/L People taking a C5i (eculizumab) saw an increase in their ARC of 28 x 10 9 cells/L Reduced ARC At Week 16 in PEGASUS, EMPAVELI was no worse than a C5i (eculizumab) in helping people with PNH reduce their ARC.

In people who had never received a C5i (PRINCE)

of people taking EMPAVELI were transfusion-free

of people in the control arm (excluding C5i) were transfusion-free

IMPORTANT SAFETY INFORMATION (cont’d) Tell your healthcare provider about all the vaccines you receive and medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements which could affect your treatment.

ARC=absolute reticulocyte count; C5i=C5 inhibitor; PNH=paroxysmal nocturnal hemoglobinuria.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

How EMPAVELI can help | LDH

Changes in LDH with EMPAVELI

Rapid and sustained LDH reductions with EMPAVELI vs control arm—in people who had never received a C5i By Week 2 in PRINCE, average LDH levels in the EMPAVELI group had dropped from baseline and remained there through 26 weeks.

Louis is an adult with PNH taking EMPAVELI.

In people who had never received a C5i (PRINCE)

*Control arm (excluding C5i) only includes data on or before escape (switching to EMPAVELI).

At Week 26, average reductions in LDH levels were: -1870 U/L in the EMPAVELI group -400 U/L in the control arm (excluding C5i)

Changes in LDH levels with EMPAVELI vs eculizumab— in people who had previously received a C5i (PEGASUS) At Week 16 in PEGASUS, it could not be determined if EMPAVELI was any worse than C5i (eculizumab) in reducing LDH.

IMPORTANT SAFETY INFORMATION (cont’d) If you stop taking EMPAVELI, your healthcare provider will need to monitor you closely for at least 8 weeks after stopping EMPAVELI. Stopping treatment with EMPAVELI may cause a breakdown of red blood cells due to PNH. Symptoms or problems that can happen due to red blood cell breakdown include: decreased hemoglobin level in your blood

tiredness pain in the stomach (abdomen) blood clots erectile dysfunction (ED)

C5i=C5 inhibitor; LDH=lactate dehydrogenase; PNH=paroxysmal nocturnal hemoglobinuria; SE=standard error.

blood in your urine shortness of breath trouble swallowing

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

How EMPAVELI can help | FATIGUE

Changes in fatigue

Changes in fatigue with EMPAVELI vs eculizumab—in people who had previously received a C5i (PEGASUS) Although it was not formally tested, people in the study were asked to report their changes in levels of fatigue at Week 16. Measuring fatigue improvement Fatigue was measured using the FACIT-Fatigue scale, a 13-question survey. In the survey, participants rated the level of impact they felt that their fatigue had on daily activities and function.

This information is for observation only and no conclusions can be made on the effect of EMPAVELI on fatigue. No comparisons can be made between those taking EMPAVELI and those taking eculizumab.

Average FACIT-Fatigue scores from beginning of study through Week 16

4-week run-in period (EMPAVELI + eculizumab)

16 weeks of EMPAVELI or eculizumab

20 25 30 35 40 45 50

This information is for observation only and no conclusions can be made on the effect of EMPAVELI on fatigue. No comparisons can be made between those taking EMPAVELI and those taking eculizumab.

43. 9

43.4

42. 2

42.5

43.6 average score for general US population

41. 8

41.0

40. 3

42. 8

32. 2

People taking EMPAVELI showed an improvement of

People taking C5i (eculizumab) showed a decrease of

32.7

32. 3

31. 6

30. 8

30.7

30. 8

28.1

points

compared to their fatigue levels at the beginning of the study

Week 2

Week 8

Baseline Day 1

Week 4 Week 6

Week 12

Week 16

EMPAVELI n eculizumab n 38 41

37 41

38 40

37 39

39 39

38 38

39 38

38 36

EMPAVELI

eculizumab

An increase of 3 or more points is seen as a clinically meaningful improvement.

The FACIT-Fatigue scale ranges from 0 to 52. Higher scores mean less fatigue. These data include people who did and did not get a transfusion during the study.

IMPORTANT SAFETY INFORMATION (cont’d) What are the possible side effects of EMPAVELI?

Andrea is an adult with PNH taking EMPAVELI.

EMPAVELI can cause serious side effects including allergic reactions. Allergic reactions can happen during your EMPAVELI infusion. Stop your EMPAVELI infusion and tell your healthcare provider or get emergency medical care right away if you get any of these symptoms during your EMPAVELI infusion: chest pain

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide. C5i=C5 inhibitor; FACIT=Functional Assessment of Chronic Illness Therapy; PNH=paroxysmal nocturnal hemoglobinuria; SE=standard error.

trouble breathing or shortness of breath swelling of your face, tongue, or throat feel faint or pass out

How EMPAVELI can help | FATIGUE

A post hoc analysis of PEGASUS data found a link between Hb and fatigue

“There was a time when I thought my Hb would never increase to a level I was happy with. With EMPAVELI, my Hb has increased which has given me more energy.” Individual experiences may vary.

In people who had previously received a C5i (PEGASUS)

10 12 14

2 4 6 8

Theresa is an adult with PNH taking EMPAVELI.

People with greater improvements in Hb showed larger reductions in fatigue

11.3

-1.2

9.9

0 -2 -4

<1.0 g/dL n=39

≥1.0-<2.0 g/dL n=8

≥2.0 g/dL n=25

Increase in Hb

People with PNH who had an Hb improvement of 1 g/dL or more had an average fatigue improvement of ~10 points .

A post hoc analysis gathers additional findings after a study has ended. It is not considered as scientifically strong as an analysis that was planned before the study began This analysis included people receiving EMPAVELI and people receiving eculizumab C5i=C5 inhibitor; FACIT=Functional Assessment of Chronic Illness Therapy; Hb=hemoglobin; PNH=paroxysmal nocturnal hemoglobinuria. Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

IMPORTANT SAFETY INFORMATION (cont’d) What are the possible side effects of EMPAVELI? (cont'd)

How EMPAVELI can help | Hb NORMALIZATION

Getting to normalization of lab values What is normalization? How is it different than stabilization? Normalization means lab values improved to levels like those of adults who don’t have PNH. This is different than stabilization, which generally means that lab values did not get worse. Hemoglobin (Hb) normalization in people with and without previous C5i treatment This information is for observation only and no conclusions can be made on the effect of EMPAVELI on Hb normalization. No comparisons can be made between those taking EMPAVELI and those taking eculizumab in PEGASUS or those in the control arm (excluding C5i) in PRINCE.

Louis is an adult with PNH taking EMPAVELI.

In people who had previously received a C5i (PEGASUS)

In people who had never received a C5i (PRINCE)

At Week 16 in PEGASUS

At Week 26 in PRINCE

34%

of people taking EMPAVELI achieved Hb normalization

46%

Hb normalization means their Hb got to within the normal range (12-16 g/dL for females, 13.6-18 g/dL for males).

EMPAVELI n=35

Control arm (excluding C5i) n=18

EMPAVELI n=41

eculizumab n=39

IMPORTANT SAFETY INFORMATION (cont’d) What are the possible side effects of EMPAVELI? (cont'd) These are not all of the possible side effects of EMPAVELI. Tell your healthcare provider about any side effect that bothers you or that does not go away. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

C5i=C5 inhibitor; PNH=paroxysmal nocturnal hemoglobinuria.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

How EMPAVELI can help | LDH NORMALIZATION

LDH normalization in people with and without previous C5i treatment

This information is for observation only and no conclusions can be made on the effect of EMPAVELI on LDH normalization. No comparisons can be made between those taking EMPAVELI and those taking eculizumab in PEGASUS or those in the control arm (excluding C5i) in PRINCE.

The majority of people taking EMPAVELI reduced their LDH levels to within the normal range (113-226 U/L).

Nearly 2/3 of people taking EMPAVELI reduced their LDH levels to within the normal range (113-226 U/L).

Jillian is an adult with PNH taking EMPAVELI.

In people who had previously received a C5i (PEGASUS)

In people who had never received a C5i (PRINCE)

At Week 16 in PEGASUS

At Week 26 in PRINCE

71%

of people taking EMPAVELI achieved LDH normalization

66%

15%

EMPAVELI n=41

eculizumab n=39

EMPAVELI n=35

Control arm (excluding C5i) n=18

Long-term Hb and LDH data

see additional data

IMPORTANT SAFETY INFORMATION What is the most important information I should know about EMPAVELI? EMPAVELI is a medicine that can affect your immune system and can lower the ability of your immune system to fight infections.

C5i=C5 inhibitor; Hb=hemoglobin; LDH=lactate dehydrogenase; PNH=paroxysmal nocturnal hemoglobinuria.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

Possible side effects

Most common side effects

Infections

Abdominal pain

Injection site reactions

Diarrhea

Respiratory tract infection Viral infection

Tiredness

EMPAVELI is only available through a program called the EMPAVELI REMS (Risk Evaluation and Mitigation Strategy). REMS is a safety program run by the FDA. Before you can take EMPAVELI, your healthcare provider must enroll in the program and will provide you with the following: Counseling on the risk of serious infections caused by certain bacteria Information about the symptoms of serious infections Appropriate vaccinations A Patient Safety Card – Carry this card with you at all times during treatment and for 2 months after your last EMPAVELI dose – Show this card to any healthcare professional to help diagnose and treat you quickly – Your risk of serious infection may continue for several weeks after your last dose of EMPAVELI EMPAVELI REMS program ensures your safety is a top priority

Serious adverse reactions were reported in 17% of patients treated with EMPAVELI - T he most common serious adverse events were infections (5%) Injection/infusion site reactions were mild or moderate in severity. Seventeen cases of diarrhea were reported during the 48 weeks. Fifteen of the cases were mild and 2 were moderate Breakthrough hemolysis occurred in 10% of those taking EMPAVELI vs 23% of those taking eculizumab at Week 16 in the PEGASUS study. Three people taking EMPAVELI left the study due to hemolysis

Injection site reactions

Infections

Viral infection

Pain in extremity

Low potassium

Joint pain

Dizziness

Abdominal pain

Rash

Headache

One patient treated with EMPAVELI died due to septic shock Serious adverse reactions were reported in 13% of patients treated with EMPAVELI Overall, there were no EMPAVELI-related side effects leading to drug or trial discontinuation No events of acute hemolysis were observed in either treatment group through Week 26 These are not all the possible side effects of EMPAVELI. Be sure to tell your healthcare provider about any side effect that bothers you or that does not go away. Side effects can be reported to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch Two people taking EMPAVELI in the PEGASUS and PRINCE studies had side effects related to blood clots. They were deemed not related to EMPAVELI There have been no cases of meningococcal infections in any studies that included people taking pegcetacoplan regularly, as of 11/13/2022. In the studies, participants were vaccinated prior to treatment with pegcetacoplan

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

Self-administering EMPAVELI

Take your treatment wherever is most convenient for you EMPAVELI is a PNH treatment that you give yourself at home or wherever works for you (after receiving proper training). EMPAVELI is self-administered subcutaneously (just under the skin). Each EMPAVELI infusion should take about 30 minutes (if using 2 infusion sites) or 60 minutes (if using 1).

No intravenous (IV) infusions No infusion center visits

No need to plan around infusion appointments

EMPAVELI is self-administered using a commercially available infusion pump with a reservoir of at least 20 mL.

When traveling, ensure that EMPAVELI stays at 36°F to 46°F (2°C-8°C). “I love to travel. With EMPAVELI self-administration, I can bring my supplies with me and travel without interrupting my treatment schedule.” Emma is an adult with PNH taking EMPAVELI. Individual experiences may vary.

PNH=paroxysmal nocturnal hemoglobinuria.

IMPORTANT SAFETY INFORMATION (cont’d) What is the most important information I should know about EMPAVELI? (cont’d) EMPAVELI may increase your chance of getting serious and life-threatening meningococcal infections that may quickly become life-threatening and cause death if not recognized and treated early. EMPAVELI may also increase the risk of getting serious infections caused by certain bacteria such as Streptococcus pneumoniae, Neisseria meningitidis , and Haemophilus influenzae type B. Serious infections may quickly become life-threatening and cause death if not recognized and treated early. 1. Y ou must be vaccinated against these bacteria at least 2 weeks before your first dose of EMPAVELI if you have not already had these vaccines.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

Self-administering EMPAVELI

How do I take EMPAVELI? EMPAVELI is self-administered just under the skin using a small, thin needle. EMPAVELI is not an IV infusion (into the vein) that requires a healthcare provider to administer it for you.

See the Instructions for Use .

Your healthcare provider will tell you how much EMPAVELI to infuse and how often to infuse. Do not infuse more or less than your healthcare provider tells you to.

How often do I take EMPAVELI? EMPAVELI is taken 2 times a week* The infusion takes about 30 minutes (if using 2 infusion sites) or 60 minutes (if using 1)

If you miss a dose of EMPAVELI, take the missed dose as soon as possible. Take your next dose as regularly planned.

If your healthcare provider decides to stop your treatment with EMPAVELI, follow their instructions for how to stop. Your healthcare provider will monitor you closely for at least 8 weeks after stopping treatment with EMPAVELI for any signs of hemolysis due to PNH.

*If there is an increase in your LDH, an enzyme in your blood, your healthcare provider may tell you to take EMPAVELI every 3 days.

watch the EMPAVELI self-administration video

you get self-administration support from the start

there are processes for transitioning to EMPAVELI

certain vaccines are required before starting EMPAVELI

LDH=lactate dehydrogenase; PNH=paroxysmal nocturnal hemoglobinuria.

Andrea is an adult with PNH taking EMPAVELI.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

ApellisAssist ® program

Emma is an adult with PNH taking EMPAVELI.

“My ACE is amazing. Her training helped give me confidence in self-administering EMPAVELI. She continues to be there for me and is always a phone call away.” Individual experiences may vary.

Support every step of the way

The ApellisAssist program is here for you

It takes teamwork to help manage PNH. The ApellisAssist patient support program provides comprehensive support, with helpful resources and experienced people dedicated to making a difference for you. With the program, you have access to: Financial assistance (for those who are eligible) Insurance support Self-administration training from an Apellis Care Educator (ACE) EMPAVELI and PNH education

Your ApellisAssist support partners With EMPAVELI, you don’t have to go it alone. Learn about your dedicated partners from the ApellisAssist program.

Care Coordinator Through our specialty pharmacy, PANTHERx Rare, a Care Coordinator will: Help schedule your deliveries for medication and supplies Explain your insurance benefits or available financial assistance options, if eligible

Apellis Care Educator (ACE) Your ACE is there for you from the start. They will provide you: 1-on-1 training on how to self-administer EMPAVELI—in your home or virtually Ongoing support every step of the way A wide variety of educational resources Answers to questions that may pop up

1-866-MY-APL-ASSIST (1-866-692-7527) FROM 8 am -8 pm ET, MONDAY-FRIDAY

Care Coordinators and ACEs do not give medical advice. Talk to your doctor for treatment-related questions.

PNH=paroxysmal nocturnal hemoglobinuria.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

ApellisAssist ® program

Helpful resources and tools

Tools for your journey Resources, tools, and tips designed for you No matter where you are in your journey, there are many resources available to help.

8 weeks of EMPAVELI treatment at no cost to eligible adults with PNH* If you haven’t tried EMPAVELI yet, you may be eligible for the EMPAVELI Trial Offer regardless of insurance coverage or current C5i treatment.

A range of brochures and guides available to download

Straightforward enrollment for you and your healthcare provider

The same comprehensive training and support as those currently taking EMPAVELI

Extensive video content including patient stories, ACE support stories, and step-by-step instructions for taking EMPAVELI

No obligation to continue with EMPAVELI after trial ends

Home Suite Home with tools and videos for traveling with, storing, and organizing your medication

If you and your healthcare provider are ready to try EMPAVELI, you may be eligible to enroll in the Trial Offer program .

*Terms, conditions, and eligibility requirements apply. Ask your doctor for more information.

Social communities to keep in touch on Facebook, Instagram, and YouTube

Insurance questions? In need of financial assistance?

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access these helpful resources for your EMPAVELI journey

Angelo is an adult with PNH taking EMPAVELI.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

ACE=Apellis Care Educator; C5i=C5 inhibitor; PNH=paroxysmal nocturnal hemoglobinuria.

PNH Peer 2 Peer program

An event planner and traveler who became her own advocate Jillian

A family man who sought out support from the PNH community Louis

Connect 1-on-1 with someone taking EMPAVELI . The PNH Peer 2 Peer program gives you the chance to connect directly with someone else who is living with PNH.

Jillian, Louis, Andrea, and Stacey are adults with

FPO

Hear about their journey living with PNH, ask them questions, and find out about their experiences starting or switching to EMPAVELI.

PNH taking EMPAVELI.

A loving grandmother who remained resilient in her path to PNH care Andrea

Your healthcare provider is your best source of information regarding your PNH.

A lover of the outdoors who found courage in the face of the unknown Stacey

Stacey is an adult with PNH taking EMPAVELI.

meet a Peer 2 Peer Connector! learn about our Connectors and schedule a time to meet

PNH=paroxysmal nocturnal hemoglobinuria.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

INDICATION AND IMPORTANT SAFETY INFORMATION

have not been vaccinated against Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type B, unless your healthcare provider decides that urgent treatment with EMPAVELI is needed. have a serious infection caused by the bacteria above. Before you take EMPAVELI, tell your healthcare provider about all of your medical conditions, including if you: have an infection or fever. are pregnant or plan to become pregnant. EMPAVELI may harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with EMPAVELI and use an effective method of birth control during treatment with EMPAVELI and for 40 days after the last dose. are breastfeeding or plan to breastfeed. It is not known if EMPAVELI passes into your breast milk. You should not breastfeed during treatment with EMPAVELI and for 40 days after the last dose. Tell your healthcare provider about all the vaccines you receive and medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements which could affect your treatment. If you stop taking EMPAVELI, your healthcare provider will need to monitor you closely for at least 8 weeks after stopping EMPAVELI. Stopping treatment with EMPAVELI may cause a breakdown of red blood cells due to PNH. Symptoms or problems that can happen due to red blood cell breakdown include: decreased hemoglobin level in your blood

What is EMPAVELI ® (pegcetacoplan)? EMPAVELI is a prescription medicine used to treat adults with a disease called paroxysmal nocturnal hemoglobinuria (PNH). What is the most important information I should know about EMPAVELI? EMPAVELI is a medicine that can affect your immune system and can lower the ability of your immune system to fight infections. EMPAVELI may increase your chance of getting serious and life-threatening meningococcal infections that may quickly become life-threatening and cause death if not recognized and treated early. EMPAVELI may also increase the risk of getting serious infections caused by certain bacteria such as Streptococcus pneumoniae, Neisseria meningitidis , and Haemophilus influenzae type B. Serious infections may quickly become life-threatening and cause death if not recognized and treated early. 1. Y ou must be vaccinated against these bacteria at least 2 weeks before your first dose of EMPAVELI if you have not already had these vaccines. 2. If your healthcare provider decides that urgent treatment with EMPAVELI is needed, you should receive the required vaccinations as soon as possible. 3. If you have not been vaccinated and EMPAVELI therapy must be initiated immediately, you should also receive 2 weeks of antibiotics with your vaccinations. 4. If you have been vaccinated against these bacteria in the past, you might need additional vaccinations before starting EMPAVELI. Your healthcare provider will decide if you need additional vaccinations. 5. Vaccines reduce the risk of serious infections, but do not prevent all serious infections. Call your healthcare provider or get emergency medical care right away if you get any of these signs and symptoms of a serious infection: fever with or without shivers or the chills fever and a rash shortness of breath extreme pain or discomfort headache with nausea or vomiting high heart rate headache and a fever headache with a stiff neck or stiff back confusion muscle aches with flu-like symptoms clammy skin eyes sensitive to light Your healthcare provider will give you a Patient Safety Card about the risk of serious infections. Carry it with you at all times during treatment and for 2 months after your last EMPAVELI dose. It is important to show this card to any healthcare provider to help them diagnose and treat you quickly. EMPAVELI is only available through a program called the EMPAVELI Risk Evaluation and Mitigation Strategy (REMS). Before you can take EMPAVELI, your healthcare provider must enroll in the EMPAVELI REMS program, counsel you about the risk of serious infections caused by certain bacteria, give you information about the symptoms of serious infections, give you a Patient Safety Card about your risk of serious infections, and make sure that you are vaccinated. Who should NOT take EMPAVELI? Do not take EMPAVELI if you: are allergic to pegcetacoplan or any of the ingredients in EMPAVELI.

tiredness pain in the stomach (abdomen) blood clots erectile dysfunction (ED)D)

blood in your urine shortness of breath trouble swallowing

What are the possible side effects of EMPAVELI? EMPAVELI can cause serious side effects including allergic reactions. Allergic reactions can happen during your EMPAVELI infusion. Stop your EMPAVELI infusion and tell your healthcare provider or get emergency medical care right away if you get any of these symptoms during your EMPAVELI infusion: chest pain

trouble breathing or shortness of breath swelling of your face, tongue, or throat feel faint or pass out

The most common side effects in people with PNH treated with EMPAVELI include injection-site reactions; infections; diarrhea; pain in the stomach (abdomen); respiratory tract infection; pain in the arms, hands, legs, or feet; low potassium in blood; tiredness; viral infection; cough; joint pain; dizziness; headache; and rash. These are not all of the possible side effects of EMPAVELI. Tell your healthcare provider about any side effect that bothers you or that does not go away. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information, including Boxed WARNING regarding risk of serious infections, and Medication Guide for additional information.

Absolute reticulocyte count (ARC) A test that measures the number of immature red blood cells in your blood. High reticulocyte counts may be a sign of ongoing hemolysis with paroxysmal nocturnal hemoglobinuria (PNH), as the body is making more new red blood cells to replace the ones being destroyed by the immune system. C3 A protein in the blood that acts as a central point of the complement system, regulating its activation. C5 Another protein in the blood that is part of the complement system. Clinical trial A type of research study that tests how well treatments work in people, as well as possible side effects of treatments. Complement system The complement system, also referred to as the complement cascade, is an army of more than 40 different proteins that work together to get rid of dangerous cells and fight infection. Extravascular hemolysis (EVH) Destruction of red blood cells that occurs in the liver or spleen. FACIT-Fatigue scale This tool consists of a number of questions that are used to assign a score to measure a person’s experience with fatigue. Globin' Acting in pursuit of higher hemoglobin levels. Hemoglobin (Hb) The critical protein found inside red blood cells that enables other cells throughout the body to get the oxygen they need. Hemoglobin acts like drops of glue that can “stick” to oxygen and carry it from the lungs to other tissues. It can also “stick” to waste like carbon dioxide to help remove it from the body.

Hemolysis The breaking apart of red blood cells. It can occur when the immune system attacks these cells as though they were dangerous viruses or bacteria. When red blood cells break open, hemoglobin is released. Hemolysis causes many of the symptoms of PNH. Immune system A sophisticated defense network used to protect the body from dangers like disease and infection. Intravascular hemolysis (IVH) The destruction of red blood cells inside a blood vessel. Lactate dehydrogenase (LDH) An enzyme found in the blood and tissues of the body, including the heart, kidneys, brain, and lungs. Red blood cell destruction results in the release of LDH into the blood. People with PNH often have higher levels of LDH due to ongoing hemolysis. Normalization Lab values improving to levels like those of adults who don’t have PNH. Proteins Molecules that play many important roles in the body and can be thought of as the “workhorses” of cells. Proteins are required for the structure, function, and regulation of the body’s organs and tissues. Red blood cells A common type of blood cell. Their job is to carry oxygen, using an important molecule, hemoglobin, around the body. Stabilization Lab values remaining at a stable level and not getting worse. U/L Some test results are reported in U/L, or units per liter. This is a measurement of how many units there are in a liter. x 10 9 cells/L A short way to write a number with 9 zeros at the end. This is useful when needing to count the billions of cells in a liter of blood.

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

If you're like Monica, an adult with PNH taking EMPAVELI,

Where will you go next?

it's time to get Globin' discover more about what's possible with EMPAVELI

you don’t have to go it alone your ApellisAssist team, including your ACE, is always at your side

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ACE=Apellis Care Educator; PNH=paroxysmal nocturnal hemoglobinuria.

APELLIS, APELLISASSIST, EMPAVELI, and their respective logos are registered trademarks of Apellis Pharmaceuticals, Inc. Other trademarks referenced herein are the property of their respective owners. ©2023 Apellis Pharmaceuticals, Inc. All rights reserved. 4/23 US-PEGPNH-2200440 v1.0

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