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Table of Contents

Hemolysis in PNH

4 6 8

[gl ow -bin] verb; Acting in pursuit of higher hemoglobin levels

How EMPAVELI works

Why EMPAVELI

Globin’ can correlate to higher levels of hemoglobin in your blood. Hemoglobin carries oxygen throughout your body—and oxygen is, you know, the stuff of life.

How EMPAVELI can help

10

Possible side effects

26

discover how you can be Globin’

Self-administering EMPAVELI

28 32 35 36 38 40

ApellisAssist ® program

Helpful resources and tools

PNH Peer 2 Peer program

Important Safety Information

Glossary

IMPORTANT SAFETY INFORMATION (cont’d) What is the most important information I should know about EMPAVELI? (cont'd) 2. If your healthcare provider decides that urgent treatment with EMPAVELI is needed, you should receive the required vaccinations as soon as possible. 3. If you have not been vaccinated and EMPAVELI therapy must be initiated immediately, you should also receive 2 weeks of antibiotics with your vaccinations. 4. If you have been vaccinated against these bacteria in the past, you might need additional vaccinations before starting EMPAVELI. Your healthcare provider will decide if you need additional vaccinations.

PNH=paroxysmal nocturnal hemoglobinuria .

Please see full Important Safety Information, including Boxed WARNING regarding risk of serious infections, on pages 38-39, and the full Prescribing Information and Medication Guide.

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