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Change in clinical attachment level (CAL) in millimeters at 1, 2, and 3 months vs. pretreatment conditions (n=34) 1

Sterify Gel + SRP only SRP

3

*

*

*

*p<0,05

2

Significant advancements were observed in clinical attachment level (CAL), with the

1

treatment group exhibiting superior progress compared to the control group 1

0

1 Month

2 Months

3 Months

Figure 1c

REDUCTION OF BACTERIAL CONTAMINATION IN PERIODONTAL POCKETS FOLLOWING TREATMENT WITH STERIFY GEL 1

Bacterial contamination of specific bacteria strains in treated and control sites

Treated Group (Sterify Gel + SRP)

++

At 3 months follow-up, a “negative shift” to less bacterial positivity was observed in the

Pre-Treatment 3 Months

+

*p<0,05

treatment group , indicating a statistically significant trend toward reduced bacterial contamination 1

+/-

-

Aggregatibacter actinomycetem.

Prevotella intermedia

Parvimonas micra

Treponema denticola

Porphyromonas gingivalis

Tannerella forsythia

Fusobacterium nucleatum

Filifactor alocis

Figure 4a

Control Group (only SRP)

++

This trend was not observed in the control group who received SRP only, where no statistically significant differences were found 1

Pre-Treatment 3 Months

+

*p<0,05

+/-

-

Aggregatibacter actinomycetem.

Prevotella intermedia

Parvimonas micra

Treponema denticola

Porphyromonas gingivalis

Tannerella forsythia

Fusobacterium nucleatum

Filifactor alocis

Figure 4b

Bacterial contamination of specific bacteria strains was assessed through qPCR of samples obtained with probe collection in (a) treated and (b) control sites. On the Y-axis, “−” means negativity (no colony-forming units, CFU); “” means low positivity (up to 10 4 CFU); “+” means moderate positivity (between 10 5 and 10 6 CFU); and “++” means high positivity (between 10 6 and 10 7 CFU). “Aggregatibacter actinomycetem” is short for Aggregatibacter actinomycetemcomitans. Error bars show SEM. 1

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