Avanti Research is excited to introduce our new brochure, which highlights the expanded line of fully synthetic complex glycosphingolipids. These high-purity glycosphingolipids provide researchers with unparalleled consistency in studies of cell signaling, immune response, neurobiology, and oncology. Discover the difference with Avanti’s synthetic glycosphingolipids—where precision meets innovation.
COMPLEX GLYCO SPHINGO LIPIDS
We’re expanding our selection of fully synthetic complex glycosphingolipids!
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High-purity, complex glycosphingolipids Glycosphingolipids, integral constituents of cell membranes, feature a sphingolipid backbone linked to a carbohydrate moiety. Comprising a diverse group of complex lipids, they assume a pivotal role in maintaining the structural integrity of the plasma membrane's outer leaflet. Their carbohydrate chains, ranging in composition and length, include sugars like glucose, galactose, and sialic acid. Functionally, glycosphingolipids are essential in cell recognition processes, facilitating communication critical for immune responses, development, and tissue differentiation. Additionally, they
Physiological and pathological relevance
Neurodegenerative disorders. Abnormalities in glycosphingolipid metabolism have been linked to neurodegenerative disorders.
Researchers are exploring the role of gangliosides, a type of glycosphingolipid abundant in the nervous system, in the pathogenesis of conditions like Alzheimer’s and Parkinson’s disease.
Cancer Glycosphingolipids, particularly gangliosides, are implicated in cancer progression and metastasis. Studies focus on
understanding how these lipids influence signaling pathways that contribute to the aggressive behavior of cancer cells. Targeting glycosphingolipids is also explored as a potential therapeutic strategy.
contribute to signal transduction as receptors for extracellular signaling molecules.
Cerebrosides, with a single sugar, gangliosides, with complex branched chains containing sialic acid, and globosides, found in non-neuronal tissues, represent distinct types of glycosphingolipids. Notably, glycosphingolipids influence blood group antigens on red blood cells and are associated with various diseases, particularly neurodegenerative disorders. The biosynthesis of glycosphingolipids occurs in the endoplasmic reticulum and Golgi apparatus, involving the sequential addition of sugar residues to the sphingolipid backbone. In summary, these molecules play multifaceted roles in cellular processes, emphasizing their significance in both physiological and pathological contexts.
Blood group determination Understanding glycosphingolipids' role in blood group antigen
expression is crucial for blood transfusions and organ transplantation. Research aims to enhance compatibility and reduce the risk of complications in these medical procedures.
Biomarkers Changes in glycosphingolipid profiles are being explored as potential biomarkers for disease
diagnosis and prognosis. Detecting alterations in these lipids could aid in the early identification of certain conditions.
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Anatomy of a complex glycosphingolipid
Fatty acid
Sphingosine backbone
Sugar chain (glycans)
Glycan symbol nomenclature Shape Generic
Blue Yellow Purple Light Blue Red
Filled Circle
Hexose
Glc
Gal
All
Tal
Filled Square Filled Triangle
TalNAc
HexNAc
GlcNAc
GalNAc AllNAc
Deoxyhexose
Qui
6dTal
Fuc
Filled Diamond
3-deoxy-nonolusonic acids
Neu5Ac
Neu5Gc
Sia
Ganglioside series
Globoside series
cer
cer
cer
cer
cer
cer
cer
GT3
GM3
GD3
Gb3
cer
Gb4
cer
cer
cer
cer
cer
cer
GT2
GA2
GM2
GD2
Forssman antigen
Gb5
cer
cer
Forssman antigen
Globo-H
cer
cer
cer
cer
GT1c
GA1
GM1a
GD1b
cer
cer
cer
Globo-B
Disalo-Gal-globoside
Globo-A
cer
cer
cer
cer
GQ1c
GM1b
GD1a
GT1b
cer
cer
cer
cer
GP1c
GD1c
GT1a
GQ1b
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C18:0-d7 GM3 ceramide (d18:1/18:0-d7) Stable Isotope-Labeled Glycolipids
Product Number: 860122 Molecular Weight: 1188.55 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860121 Molecular Weight: 1391.74 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860120 Molecular Weight: 1553.88 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860123 Molecular Weight: 1479.80 Purity: >97% Package Size: 100 µg Physical State: Methanol Soln. Availability: Now Available! Product Number: 860124 Molecular Weight: 1683.00 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860125 Molecular Weight: 1845.14 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available!
C18:0-d7 GM2 ceramide (d18:1/18:0-d7)
C18:0-d7 GM1 ceramide (d18:1/18:0-d7)
C18:0-d7 GD3 ceramide (d18:1/18:0-d7)
C18:0-d7 GD2 ceramide (d18:1/18:0-d7)
C18:0-d7 GD1b ceramide (d18:1/18:0-d7)
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C18:0-d7 GT3 ceramide (d18:1/18:0-d7) Stable Isotope-Labeled Glycolipids
Product Number: 860126 Molecular Weight: 1771.06 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Coming Soon! Product Number: 860127 Molecular Weight: 1059.43 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860128 Molecular Weight: 1262.63 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860129 Molecular Weight: 1700.03 Purity: >97% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available!
C18:0-d7 GB3 ceramide (d18:1/18:0-d7)
C18:0-d7 GB4 ceramide (d18:1/18:0-d7)
C18:0-d7 Fuc-GM1 ceramide (d18:1/18:0-d7)
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GM3 Derivatives
cer
GM3 sphingosine (d18:1)
Product Number: 860132 Molecular Weight: 915.04 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860074 Molecular Weight: 1198.52 Purity: >99% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860168 Molecular Weight: 1263.65 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860156 Molecular Weight: 1197.51 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 810258 Molecular Weight: 1346.40 Purity: >99% Package Size: 100 µg Physical State: Ethanol soln. Availability: Now Available!
C18:0 GM3 ceramide (d18:1/18:0)
C24:1 GM3 ceramide (d18:1/24:1)
GM3 Derivatives - Modified
C18:0 GM3(Neu5Gc) ceramide (d18:1/18:0)
C11:0 (11-TopFluor®) GM3 ceramide (d18:1/11:0)
GM2 Derivatives
cer
GM2 sphingosine (d18:1)
Product Number: 860131 Molecular Weight: 1118.23 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available!
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C18:0 GM2 ceramide (d18:1/18:0)
Product Number: 860140 Molecular Weight: 1384.70 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860141 Molecular Weight: 1466.85 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860157 Molecular Weight: 1400.70 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860130 Molecular Weight: 1280.37 Purity: >97% Package Size: 1mg Physical State: Powder Availability: Now Available! Product Number: 860094 Molecular Weight: 1548.85 Purity: >99% Package Size: 100 µg Physical State: Powder Availability: Now Available! Product Number: 860088 Molecular Weight: 1591.93 Purity: >97% Package Size: 100 µg Physical State: Powder Availability: Now Available!
C24:1 GM2 ceramide (d18:1/24:1)
GM2 Derivatives - Glycan Modified
C18:0 GM1(Neu5Gc) ceramide (d18:1/18:0)
GM1 Derivatives
cer
GM1 sphingosine (d18:1)
C17:0 GM1 ceramide (d18:1/17:0)
C20:0 GM1 ceramide (d18:1/20:0)
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C24:1 GM1 ceramide (d18:1/24:1)
Product Number: 860139 Molecular Weight: 1426.51 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860143 Molecular Weight: 1692.98 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860158 Molecular Weight: 1562.84 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 810170 Molecular Weight: 1741.98 Purity: >99% Package Size: 500 µg Physical State: Powder Availability: Now Available! Product Number: 860097 Molecular Weight: 1950.34 Purity: >99% Package Size: 100 µg Physical State: Powder Availability: Now Available! Product Number: 860142 Molecular Weight: 1628.99 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon!
Fuc-GM1 sphingosine (d18:1) GM1 Derivatives - Glycan Modified
C18:0 Fuc-GM1 ceramide (d18:1/18:0)
C18:0 GM1(Neu5Gc) ceramide (d18:1/18:0)
C18:0 (2-NBD) GM1 ceramide (d18:1/18:0) GM1 Derivatives - Fatty Acid Modified
C18:0 (2-Biotin) GM1 ceramide (d18:1/18:0)
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cer
GD3 Derivatives
GD3 sphingosine (d18:1)
Product Number: 860133 Molecular Weight: 1206.29 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860144 Molecular Weight: 1472.76 Purity: >99% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860134 Molecular Weight: 1409.49 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860145 Molecular Weight: 1675.96 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860135 Molecular Weight: 1571.63 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860163 Molecular Weight: 1758.10 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon!
C18:0 GD3 ceramide (d18:1/18:0)
GD2 Derivatives
cer
GD2 sphingosine (d18:1)
C18:0 GD2 ceramide (d18:1/18:0)
C24:1 GD2 ceramide (d18:1/24:1)
GD1b Derivatives
cer
GD1b sphingosine (d18:1)
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C18:0 GD1b ceramide (d18:1/18:0)
Product Number: 860146 Molecular Weight: 1838.10 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860075 Molecular Weight: 1841.08 Purity: >99% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available! Product Number: 860091 Molecular Weight: 1872.16 Purity: >99% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available!
cer
GD1a Derivatives
C17:0 GD1a ceramide (d18:1/17:0)
C18:0 GD1a ceramide (d18:1/18:0)
cer
GT3 sphingosine (d18:1) GT3 Derivatives
Product Number: 860136 Molecular Weight: 1497.55 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860089 Molecular Weight: 2180.45 Purity: >99% Package Size: 100 µg Physical State: Methanol soln. Availability: Now Available!
cer
GT1b Derivatives
C18:0 GT1b ceramide (d18:1/18:0)
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GB3 Derivatives
cer
GB3 sphingosine (d18:1)
Product Number: 860137 Molecular Weight: 785.92 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860699 Molecular Weight: 1038.36 Purity: >99% Package Size: 500 µg Physical State: Powder Availability: Now Available! Product Number: 860147 Molecular Weight: 1052.39 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860167 Molecular Weight: 1134.54 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860720 Molecular Weight: 785.91 Purity: >97% Package Size: 500 µg Physical State: Powder Availability: Now Available!
C17:0 GB3 ceramide (d18:1/17:0)
C18:0 GB3 ceramide (d18:1/18:0)
C24:1 GB3 ceramide (d18:1/24:1)
iGB3 Derivatives
iGB3 sphingosine (d18:1)
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C17:0 iGB3 ceramide (d18:1/17:0)
Product Number: 860722 Molecular Weight: 1038.35 Purity: >99% Package Size: 500 µg Physical State: Powder Availability: Now Available! Product Number: 860138 Molecular Weight: 989.12 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860150 Molecular Weight: 1255.59 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available! Product Number: 860166 Molecular Weight: 1337.73 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860155 Molecular Weight: 1198.53 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Now Available!
GB4 Derivatives
cer
GB4 sphingosine (d18:1)
C18:0 GB4 ceramide (d18:1/18:0)
C24:1 GB4 ceramide (d18:1/24:1)
B-Antigen Derivatives
cer
C18:0 B-Antigen ceramide (d18:1/18:0)
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Lc3 Derivatives
cer
C18:0 Lc3 ceramide (d18:1/18:0)
Product Number: 860164 Molecular Weight: 1093.44 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon! Product Number: 860165 Molecular Weight: 1255.59 Purity: >97% Package Size: 1 mg Physical State: Powder Availability: Coming Soon!
Lc4 Derivatives
cer
C18:0 Lc4 ceramide (d18:1/18:0)
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