Our Centres of Excellence
isto
brella, the
Under the Purelab u
patibility
rst
s Laboratory (H LA Lab
was
eneti
mm uno
established in the early 2000s as a Medi
al Resear
h
ospital. Today, the laboratory proudly
Centre in Mafra
irates transplant
ser the De
es the United Arab E
mm unity as
ain referral laboratory for both the Li in
and
ides a hi patibility
ra mm e. It pro
h
eased-Donor Transplant Pro
iali
isto
ed state-of-the-art
plexity spe
to support both solid or
s testin
an
eneti
and I mm uno
,
reas
Kidney, Li
er, Lun
and
eart and Pan
ell transplantation. Currently, the
ste
atopoieti
laboratory pro ra mm es and ore than 20 hospitals within the Purelab network in the UAE. Close ollaboration between Transplant mm unolo ists and lini ians is funda ental to ensurin ood patient out es. This in ol es Pre- Post-Transplant testin to assess i mm unolo al risks and proper patient ana ent. ides six or transplant pro
The HLA Laboratory performs pre-transplant testing and consultation in four major areas:
1. HLA genotyping for recipients and donors. Results: Better match of HLA antigens and lower chance for harmful post-transpla nt immune reactions. 2. HLA antibody detection and characterization that could cause potential complications at the time of transplant. The introduction of (Single Antigen Bead-SAB) testing. Results: Vastly improved antibody identification and caters to all transplant progra mmes.
, whi
low
(F CXM
ross-
3.
hin
ines if the patient has
yto
at
etry
h deter
LA antibodies that are spe
fic
to a potential donor. Results: It plays a crucial role in detection and assists in designing desensitization p rotocols.
4. Virtual crossmatch (VXM): The laboratory provides virtual cross matches for potential recipient donor pairs in the deceased donor programme. Results: Accurate prediction of crossmatch results when the patient's antibody spec ificities have been identified using single HLA antigen bead technologies and the potential donor HLA ty pe is known.
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