WHAT IS A DE NOVO VARIANT?
❑ Only found in the autistic child on one chromosome (heterozygous) ❑ Originated in the sperm or egg of the parent
❑ De novo variants are preferentially inherited from older fathers ❑ Sperm is produced throughout life and is more susceptible to de novo changes with age
(Antaki et al, Nature Genetics, 2022)
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