Genetic changes of the synapse cause multiple neuropsychiatric disorders of development
Fragile X Syndrome mutation leads to enhanced Glutamate signaling
FMR-KO+ mGluR5 Het
FMR-KO
mGluR5 Het
Wild Type
Mushroom
Stalk
Glutamate mGluR5 receptor antagonism reverses the FMR1 disease
FXS accounts for ~1% of ASD
40% of those with FXS have ASD
G Dolen, M Bear, 2007
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