Courtney R. McDermott, PhD Columbia University
Aversa et al., (2021) Slykerman et al., (2019) Lavebratt et al., (2019) Wimberley et al., (2018)
Chung et al., (2021) Niarchou et al., (2019) Duyzend & Eichler et al., (2015) Blumenthal et al., (2014)
Postnatal antibiotic exposure
16p11.2 microdeletion copy number variation
Association with NDDs
Warrants investigation of underlying biological mechanisms
Accounts for ~1% ASD cases
Early life treatment with antibiotic altered the gut microbiome, brain development, and behavior, and these effects were magnified in mice that were carrying the 16p11.2 CNV
McDermott et al., bioRxiv: https://doi.org/10.1101/2025.02.25.639888
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