Ge 2022 | Anti-inflammatory effect
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Ge R, Zhu Q, Liu D, Zhang Q, Jiang S, Yu X, Shu J, Gao F, Guo J, Chen S, Gao B. Quantitative proteomics reveals potential anti-inflammatory protein targets of radial extracorporeal shock wave therapy in TNF- α -induced model of acute inflammation in primary human tenocytes. Heliyon. 2022 Dec 2;8(12):e12008.
In vitro laboratory study on human tenocytes. • The present study demonstrated that rESWT reversed the TNFα -induced decline in primary human tenocyte proliferation and increase in IL- 1β levels. • Based on the findings in vitro, the authors speculated that ITGA2, SELS, and NLRC4 are potential anti-inflammatory protein targets of rESWT in a TNF- α -induced model of acute inflammation in primary human tenocytes. • The authors further hypothesize that rESWT can prevent tendinopathy from progressing to the chronic stage by regulating the inflammatory response in the acute or subacute stages, which may open new opportunities for clinical treatment. • Low-to moderate-energy rESWT resulted in fewer immediate cytodestructive effects and greater stimulation of cell proliferation, which are in agreement with previous findings.
Key message RSW was shown in-vitro to have an anti-inflammatory effect in tendinopathies and may prevent tendinopathy from progressing to the chronic stage by regulating the inflammatory response in the acute or subacute stages. Pubmed iEnovis
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