Huang 2024 | Tissue repair | RSW
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Huang M, Shao H, Zhang S, Gao H, Feng S, Sun L, Yu C, Du X, Chen J, Li Y. Single-Dose Radial Extracorporeal Shock Wave Therapy Modulates Inflammation During Meniscal Tear Healing in the Avascular Zone. Am J Sports Med. 2024 Mar;52(3):710-720.
Controlled laboratory study on rats. Methods: Avascular tears were induced in the medial meniscus (MM) of 72 Sprague-Dawley rats. One week postoperatively, the rats received a single session of RSWT with a Power+ handpiece (ESWT group; n = 36) or with a fake handpiece (sham-ESWT group; n = 36). Results • Histological and imaging showed the ESWT group had significantly better meniscal healing scores than the sham-ESWT group at 4 and 8 weeks postoperatively. • Immunohistological evaluation showed ESWT significantly modulated the inflammation process : • The IL- 1β level was significantly higher in the sham -ESWT group than in the ESWT group at 2 and 8 weeks. • The IL-6 level was significantly lower in the sham-ESWT group than in the ESWT group at 2 and 4 weeks but higher at 8 weeks. • Histological evaluation of cartilage showed a higher degree of cartilage degeneration in the sham-ESWT group and according to the OARSI osteoarthritis cartilage histopathology assessment system, the sham group had significantly higher osteoarthritis scores than the ESWT group at 4 and 8 wks.
Key message Radial ESWT can be considered a potential option for improving meniscal tear healing in the avascular zone because of its ability to modulate inflammation.
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