Yan 2008 | Effect on blood supply
Back to overview
Yan X, Zeng B, Chai Y, Luo C, Li X. Improvement of blood flow, expression of nitric oxide, and vascular endothelial growth factor by low-energy shockwave therapy in random-pattern skin flap model. Ann Plast Surg. 2008 Dec;61(6):646-53.
Randomised controlled animal laboratory study on 84 adult male Sprague- Dawley rats. The ischemic portion of a skin flap was treated with (treatment group, n=42) or without (control group, n=42) ESWT.
Results: • Blood perfusion , expression of nitric oxide ( NO ) and vascular endothelial growth factor ( VEGF ), vasodilatation of pre-existing vessels were significantly promoted in the ESWT group compared to the control group at early postoperative stage. • Neovascularization were significantly promoted in the ESWT group compared to the control group at late stage. • Flap survival was signif. better in treatment group compared to the control group.
Key message: ESWT can significantly improve blood perfusion of ischemic flaps postoperatively and augment flap survival.
iEnovis
Pubmed
• Around 50% higher survival area and survival rate in the treatment group.
Conclusion: ESWT can improve skin flap surviving rate through enhanced vasodilatation at early postoperative stage and neovascularization at late stage via modulation of angio-active factors expression.
9
© 2022 Enovis Corporation
CONFIDENTIAL
Made with FlippingBook - PDF hosting