Wherever your child is in their journey, the right support matters. These tools will help guide you and your child through next steps with CRENESSITY—from understanding their lab results to working with your child’s doctor to adjust their care plan. Each resource was created with your child in mind, to help them feel informed, supported, and ready for what’s ahead.
Taking the Next Step With CRENESSITY A brochure that can help prepare you and your child for lowering their steroid dose, if that’s part of their
treatment goal. See five case studies from real people taking CRENESSITY and how they lowered their steroid dose step-by-step under their doctor’s guidance.
Taking the next step with CRENESSITY
Know Your Child’s Labs A guide to the key lab values measured as part of your child’s CAH management plan, why they’re important numbers to know, and how they impact your child’s treatment.
Real people. Different ages. Different steroids.
A guide to your numbers and why they matter
Together with how you feel and what signs and symptoms you’re experiencing, lab values are what doctors use to make decisions about your care. Labs are a valuable tool for you, too. They can help you better understand why you feel the way you feel and can help you get more out of conversations with your doctors. Talk to your doctor about appropriate lab ranges for you.
Essential bloodwork for people with congenital adrenal hyperplasia (CAH)
Blood test
What it measures
Why it’s important
Understanding your results
Discover how they each found a path to lower steroid doses with CRENESSITY
• An indicator of androgen control • Lower levels are associated with better CAH management • Higher levels are associated with acne, early puberty, and fertility issues • High androgen levels may be treated with CRENESSITY (a CRF 1 antagonist) or an increased steroid dose • Similar to androstenedione, 17-OHP is an indirect measure of how well androgen levels are managed • Lower levels are associated with better CAH management • Higher levels may be treated with CRENESSITY (a CRF 1 antagonist) or an increased steroid dose • Testosterone helps support muscle and bone mass. High levels are associated with excess facial hair growth and acne and can cause early puberty in children. • High levels in females are associated with poor CAH management and can cause deepening of the voice and other symptoms, like excess facial hair • Helps measure whether you are getting enough salt and mineralocorticoid (fludrocortisone) • Renin helps maintain a healthy blood pressure and prevent levels of electrolytes that are too low
Levels of the hormone androstenedione, which is an ingredient the body uses to make different androgens. Sometimes abbreviated A4, it also has slight testosterone-like effects in the body.
• Your target range depends on a number of factors including age and gender • For men, the target range for androstenedione is optimally less than half the level of testosterone. Your doctor may refer to this as the “A4 to T ratio”
The profiles in this brochure are based on real experiences from the CAHtalyst™ studies. Names and personal details have been changed. Your or your child’s treatment may differ—even if age or steroid type is the same. Never change steroid doses without talking to your doctor.
Androstenedione (A4)
Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH). SELECT IMPORTANT SAFETY INFORMATION Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.
Levels of 17 OHP, also called 17-hydroxyprogesterone, a hormone that the adrenal glands use to make androgens.
• Target range is based on a number of factors. If CAH is treated with steroids alone, values in the “normal” range of your lab report may suggest that steroid doses are too high
17-0HP
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Please see additional Important Safety Information on page 6 and Patient Information .
• In females, total testosterone higher than the upper limit of normal indicates poor CAH management • In males, the ratio of androstenedione to testosterone (A4 to T, or A4/T) helps determine whether CAH is well managed • Target range is low to normal unless you have high blood pressure • Elevated renin levels suggest that salt and/or mineralocorticoid (fludrocortisone) doses, or water intake, may be too low • Low, or suppressed, renin suggests that the dose of salt and/or fludrocortisone may be too high
Testosterone (T)
Levels of the hormone testosterone, an androgen.
Levels of renin, which the body releases into the bloodstream when electrolyte (salt) levels are too low or you are dehydrated.
Plasma renin activity (PRA)
CRF 1 =corticotropin-releasing factor receptor 1.
CRENESSITY TM (crinecerfont) is the first and only FDA-approved CRF 1 antagonist to treat classic CAH. Learn more at CRENESSITY.com
Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH). SELECT IMPORTANT SAFETY INFORMATION Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY. Please see full Patient Information.
Would you like to inform and encourage other caregivers for those starting or continuing their CRENESSITY journey? Begin your application now!
SELECT IMPORTANT SAFETY INFORMATION The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain. The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds. These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Full Important Safety Information on last page and Patient Information.
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