Wherever you are in your journey, the right support matters. These tools will help guide your next steps with CRENESSITY—from understanding your lab results to working with your doctor to adjust your care plan. Each resource was created with you in mind, to help you feel informed, supported, and ready for what’s ahead.
Know Your Labs A guide to the key lab values measured as part of your CAH management plan, why they’re important numbers to know, and how they impact your treatment.
A guide to your numbers and why they matter
Together with how you feel and what signs and symptoms you’re experiencing, lab values are what doctors use to make decisions about your care. Labs are a valuable tool for you, too. They can help you better understand why you feel the way you feel and can help you get more out of conversations with your doctors. Talk to your doctor about appropriate lab ranges for you.
Essential bloodwork for people with congenital adrenal hyperplasia (CAH)
Blood test
What it measures
Why it’s important
Understanding your results
• An indicator of androgen control • Lower levels are associated with better CAH management • Higher levels are associated with acne, early puberty, and fertility issues • High androgen levels may be treated with CRENESSITY (a CRF 1 antagonist) or an increased steroid dose • Similar to androstenedione, 17-OHP is an indirect measure of how well androgen levels are managed • Lower levels are associated with better CAH management • Higher levels may be treated with CRENESSITY (a CRF 1 antagonist) or an increased steroid dose • Testosterone helps support muscle and bone mass. High levels are associated with excess facial hair growth and acne and can cause early puberty in children. • High levels in females are associated with poor CAH management and can cause deepening of the voice and other symptoms, like excess facial hair • Helps measure whether you are getting enough salt and mineralocorticoid (fludrocortisone) • Renin helps maintain a healthy blood pressure and prevent levels of electrolytes that are too low
Levels of the hormone androstenedione, which is an ingredient the body uses to make different androgens. Sometimes abbreviated A4, it also has slight testosterone-like effects in the body.
• Your target range depends on a number of factors including age and gender • For men, the target range for androstenedione is optimally less than half the level of testosterone. Your doctor may refer to this as the “A4 to T ratio”
Androstenedione (A4)
Levels of 17 OHP, also called 17-hydroxyprogesterone, a hormone that the adrenal glands use to make androgens.
• Target range is based on a number of factors. If CAH is treated with steroids alone, values in the “normal” range of your lab report may suggest that steroid doses are too high
17-0HP
• In females, total testosterone higher than the upper limit of normal indicates poor CAH management • In males, the ratio of androstenedione to testosterone (A4 to T, or A4/T) helps determine whether CAH is well managed • Target range is low to normal unless you have high blood pressure • Elevated renin levels suggest that salt and/or mineralocorticoid (fludrocortisone) doses, or water intake, may be too low • Low, or suppressed, renin suggests that the dose of salt and/or fludrocortisone may be too high
Testosterone (T)
Levels of the hormone testosterone, an androgen.
Levels of renin, which the body releases into the bloodstream when electrolyte (salt) levels are too low or you are dehydrated.
Plasma renin activity (PRA)
CRF 1 =corticotropin-releasing factor receptor 1.
CRENESSITY TM (crinecerfont) is the first and only FDA-approved CRF 1 antagonist to treat classic CAH. Learn more at CRENESSITY.com
Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH). SELECT IMPORTANT SAFETY INFORMATION Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY. Please see full Patient Information.
SELECT IMPORTANT SAFETY INFORMATION The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain. The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds. These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.
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