Starter Kit | CRENESSITY® crinecerfont

The Impact of CRENESSITY for Liam

“Before starting CRENESSITY, my androgen levels such as 17-OHP were relatively high, but after starting CRENESSITY, they significantly lowered” -Liam

Liam has CAH, is taking CRENESSITY and is a paid partner of CRENESSITY

Before taking CRENESSITY

After 4 weeks of CRENESSITY

Liam - Living with CAH and taking CRENESSITY

15% reduction

Androstenedione

72 ng/dL

61 ng/dL

90% reduction

17-OHP

692 ng/dL

71 ng/dL

Honest Stories. Relatable Experiences. Genuine Support. Whether you’ve just started taking CRENESSITY or have been taking it for some time, your Starter Kit is designed to help you feel confident, supported, and empowered. As with any change in treatment, staying informed is important. This Starter Kit gives you instant access to a variety of educational resources about CRENESSITY and classic CAH management, to access throughout your CAH treatment journey.

Before taking CRENESSITY

After 24 weeks of CRENESSITY

30% reduction*

Hydrocortisone

25 mg/day

17.5 mg/day

17-OHP = 17-hydroxyprogesterone *As part of the CAHtalyst TM clinical study in adults

The Clinical Studies: A Quick Refresher. In clinical studies, CRENESSITY helped adults improve or maintain androgen control, allowing them to lower their steroid doses. In adults: After 4 weeks, androstenedione levels dropped by an average of 299 ng/dL with CRENESSITY and increased by 46 ng/dL in those taking placebo. After 24 weeks, steroid doses were reduced by an average of 27% with CRENESSITY and 10% for those taking placebo.

Want a refresher of the brochures in your Welcome Kit? Access digital copies.

SELECT IMPORTANT SAFETY INFORMATION Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Please see Full Important Safety Information on last page and Patient Information.

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