Directing Biosynthesis VI - Book of abstracts

Programme

Tuesday 28 June 2022 (all timings are BST)

Session 3: Biosynthetic engineering I Session chair: Sacha Pidot

Repurposed biocatalysts for the assembly of antibiotics and toxins Christian Hertweck Leibniz Institute for Natural Product Research and Infection Biology (HKI), Germany Engineering of polyketide synthase leads to ‘low-fat’ stambomycins Su Li** Max-Planck-Institute for Terrestrial Microbiology, Germany

09.00

K04

09.40

C05

10.00 CRISPR-Cas9 in vivo editing enables rapid engineering of a complex antibiotic assembly line Wei Li Thong University of Manchester, UK

C06

Towards new more efficient and clinically relevant lincosamide antibiotics Zdenek Kamenik Institute of Microbiology Czech Acad Sci, Czech Republic

10.20

C07

Refreshments South Hall Kindly sponsored by:

10.40

Session 4: Unusual C-C bond forming enzymes Session chair: Sarah Barry

New insights into cobalamin-dependent methyltransferase reactions Squire Booker** Pennsylvania State University, USA Biosynthesis of the unusual carbon skeleton of nocuolin A T eresa Patricia Martins CIIMAR, Portugal

11.10

K05

11.50

C08

12.10 Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead Katherine Bauman University of San Diego, USA

C09

Flash poster presentations (odd numbers)

12.30

** presenting online

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