B
C
A
5. Gain of function experiments using a model of Down Syndrome with partial trisomy of chromosome 21 is able to rescue the pro-tumorigenic phenotype induced by 21q loss 6. 21q loss pro- tumorigenic phenotype is driven by suppression of the interferon signaling
D
E
F
G
Conclusions: our findings indicate that metastatic dissemination of clear-cell and non-clear-cell RCC is driven by CIN, following a model of punctuated equilibrium. We also discovered a tumor suppressive role of chromosome 21q. These findings elucidate molecular drivers of metastatic dissemination in RCC and may provide new biomarkers to intercept and prevent aggressive clinical behavior.
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