HLVIReport 2023

Cardiac PET The medical center’s Cardiac PET uses Positron Emission Therapy (PET) to measure blood flow to the heart. This is a type of stress tests that allows clinicians to detect coronary artery disease. The Benefits of PET • Detects disease in blood vessles that are too small to be seen by the naked eye on an angiogram • Improved diagnostic accuracy compared to SPECT (another way to measure

myocardial blood flow) • Low radiation exposure • Test is completed in about 30 minutes

Cardiac PET Research HLVI helps the medical center meet its mission of discovery by conducting medical research through the Graduate School of Medicine and the Office of Clinical Trials. Here are some examples of recent research studies conducted by HLVI: •.Aurora trial enrollment (the medical center enrolled first patient in the world and was a top recruiter) • Flurpiridaz F-18 PET Myocardial Perfusion Imaging in Patients With Suspected Coronary Artery Disease | Journal of the American College of Cardiology (jacc.org) •.Upcoming involvement in additional flurpiridaz research to define the optimal protocol for flurpiridaz imaging (how to get best results with least radiation/time). What’s New with Cardiac PET •.Starting early in 2024 myocardial blood flow quantification will be available for every PET ordered • MBFQ (Myocardial Blood Flow Quantification) allows for measurement of absolute blood flow in each coronary territory - Improved diagnostic accuracy - Diagnosis of microvascular dysfunction - Evaluation of effectiveness of stress (was the test adequate to detect a problem)

6 | HLVI Annual Report

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