Formulated products under the microscope N.A. Belsey 1,2 , D. Tsikritsis 1 , P. Zarmpi 3 , V. Tyagi 1,3 , A. Maciel-Tabosa 3 , J-L. Vorng 1 , A. Dexter 1 , M.B. Delgado-Charro 3 and R.H. Guy 3 1 National Physical Laboratory, UK; 2 University of Surrey, UK; 3 University of Bath, UK. Confocal Raman spectroscopy is a well-established tool to map chemical distribution in formulated products, for example pharmaceutical tablets. However, for high resolution imaging, or investigating dynamic processes, the relatively long acquisition times to generate 3D maps can be limiting. Stimulated Raman scattering (SRS) microscopy is a valuable new tool to assess formulated products. High resolution 3D chemical images can be acquired in ‘real time’ to reveal ingredient (co-)localization, crystalline phase, impurities and more. In addition, ingredients can be monitored post-application to the skin, to reveal mechanistic information such as penetration pathway and direct visualisation of metamorphosis. 1,2 Due to their non-destructive nature, they can also be performed in tandem with other methods. Acknowledgements: The Analytical Chemistry Trust Fund and the Community for Analytical Measurement Science is gratefully acknowledged for a CAMS Fellowship to N.A.B. This research was funded in part by the U.S. Department of Health & Human Services, Food & Drug Administration (1U01FD006533-01). The National Physical Laboratory is operated by NPL Management Ltd, a wholly owned company of the Department for Business, Energy and Industrial Strategy (BEIS). References
1. G. Saar et al , Molecular Pharmaceutics, 8, (2011) 969-975. 2. A. Belsey et al , Journal of Controlled Release, 174 (2014) 37-42.
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