Capillary zone electrophoresis for the detection of active pharmaceutical ingredients in wastewater Emma O’Sullivan-Carroll 1,2 , Anna Hogan 1 , Stewart Howlett 2 , Marguerite Lynch 2 , Carmel Pyne 2 , Paul Downing 2 , Eric Moore 1 1 Sensing and Separation Group, School of Chemistry, University College Cork, Ireland, 2 Hovione Ltd, Loughbeg, Ireland. Pharmaceutical pollution in environmental waters is an emerging problem. One of the contributing sources of this type of pollution is from pharmaceutical manufacturing waste. While more research is required to remove the active pharmaceutical ingredients (APIs) from the effluents, research is being conducted to detect the APIs in wastewater ensuring that they are a safe level to release into the environment. High performance liquid chromatography (HPLC) is the traditional method used to detect the pharmaceuticals in environmental waters. While HPLC has many benefits over up-and-coming methods, it does require the use of organic solvents. Capillary electrophoresis (CE) is now gaining attention for the detection of pollutants in the environment as it not only provides a faster analysis when compared to HPLC, but it also requires none or fewer organic solvents making it the more environmentally friendly choice for this type of research. This research is a collaboration between Hovione Ltd, Cork and University College Cork to develop a CE method to detect Hovione’s APIs in wastewater. Capillary zone electrophoresis (CZE) methods were developed for two of Hovione’s APIs: NB and ZB.
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