Fabrication of novel nanobiocomposite based on Au modified biopolymer/Zn Metal organic frameworks for neurotransmitter sensing application D. Nathiya and J. Wilson* Polymer Electronics Lab, Department of Bioelectronics and Biosensors, Alagappa University, India Email: nathiyad725@gmail.com
Fig. 1 SWV of 5-HT sensing for Au@CA/Zn-MOF modified GCE in 0.1 M PBS at pH 7.0 Research on the development of natural products based materials for the sensing of biomolecules by electrochemical method is becoming a hot area of research. Herein, a biopolymer Carrageenan (CA), surface modified with gold nanoparticles (Au) and successfully decorated with Zn – Metal Organic Frameworks (Zn- MOF), exhibits an effective role as nanobiocomposite in selective biosensing application, was constructed. The morphology of Zn-MOF decorated Au modified CA (Au@CA/Zn-MOF) based nanobiocomposite was studied by Scanning electron microscopy (SEM) and its affirmed interactions were characterized by X-ray diffraction (XRD), Raman, FT-IR spectroscopy, UV-Visible spectroscopy. After the successful reinforcement of Zn-MOF in Au@CA film, was deposited on the glassy carbon electrode (GCE) and its electrochemical behavior towards serotonin (5-HT) were also studied by cyclic voltammetry (CV), Square wave voltammetry (SWV) and amperometry in phosphate buffer solution (PBS) at pH 7.0. It exhibited an excellent electrocatalytic activity towards selective sensing of 5-HT in the wide linear range of 10 nM to 1 mM with a lower detection limit of 2 nM and also employed for the determination of 5-HT concentration in human urine samples with high selectivity and sensitivity. Results confirm the novel nanobiocomposite paves potential application for the detection of neurotransmitter content in clinical samples
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