Longevity Medical Institute Research eBook

Discover our eBook - the most comprehensive compilation of stem cell research, featuring the latest studies, breakthroughs, and applications in regenerative medicine.

Research Studies Our comprehensive repository of research studies, accessible to our team and patients, reinforces the evidence-based approach behind each service we offer. Whether it's the proven efficacy of stem cell therapies, the benefits of hyperbaric oxygen therapy, or advancements in photobiomodulation light, LMI remains at the forefront of medical innovation, delivering protocols that are not only state-of-the-art but also rigorously validated by science. This commitment to research empowers us to provide the highest standard of care, ensuring our patients receive therapies that are both transformative and scientifically grounded.

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Table of Contents Stem Cell Research Studies (Pages 5–26) Page 5: Longevity Page 6: Anti-Aging Page 7: Wrinkles/Sagging Skin Page 8: Menopause Page 9: Osteoporosis and Fractures Page 10: Cognitive Decline Page 10:Hearing Loss Page 10: Cataracts & AMD Page 11: Hair Loss Page 11: Heart Disease Page 12: Musculoskeletal Issues Page 12: Chronic Pain Page 12: Arthritis Page 13: Tendon/Ligament Injuries Page 13: Joint Issues Page 14: Spinal Disc Degeneration Page 14: Sports Injuries Page 15: Metabolic Disorders Page 15: Type II Diabetes Page 16: Obesity Page 16: Reproductive & Sexual Wellness Page 17: Erectile Dysfunction

Page 17: Libido Decline Page 18: Endometriosis Page 18: Chronic Venous Insufficiency & Varicose Veins Page 18: Peripheral Neuropathy Page 18: Balance Disorders & Fall Prevention Page 19: Thyroid Disorders (Hypothyroidism & Hyperthyroidism) Page 19: Cushing's Syndrome Page 19: Addison's Disease Page 20: Parathyroid Disorders (Hyperparathyroidism &

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Hypoparathyroidism) Page 20: Eczema Page 20: Chronic Sinusitis Page 21: Sarcoidosis Page 21: Polycystic Ovary Syndrome (PCOS) Page 21: Epilepsy Page 21: Hypoxic-Ischemic Encephalopathy (HIE) Page 21: Heavy Metals Page 22: Radiation Page 22: Drug Related Page 22: COPD (Chronic Obstructive Pulmonary Disease) Page 22: Long-COVID Page 22: Asthma Page 23: Kidney Disease

Page 23: Fatty Liver Page 23: Cirrhosis Page 23: Diabetic Foot Page 23: Wound Healing

Page 24: Alzheimer's Disease Page 24: Parkinson's Disease Page 24: Multiple Sclerosis (MS) Page 24: Stroke Recovery Page 24: ALS (Amyotrophic Lateral Sclerosis) Page 25: Spinal Cord Injuries

Page 25: Crohn's Disease Page 25: Ulcerative Colitis Page 25: Rheumatoid Arthritis (RA) Page 25: Lupus (SLE) Page 26: Psoriasis Hyperbaric Oxygen Therapy (HBOT) Research Studies (Pages 26–27) Page 26: Anti-Aging and Telomere Lengthening Page 26: Cognitive Recovery and Neurological Benefits Page 26: Fibromyalgia Syndrome

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Page 26: Traumatic Brain Injury Page 27: Radiation-Induced Tissue Damage Page 27: Diabetic Foot Ulcers Page 27: Long COVID Page 27: PTSD Treatment Page 27: Chronic Wound Healing

Page 27: Sports Recovery Page 27: Ischemic Stroke Molecular Hydrogen Inhalation Studies (Pages 28–29) Page 28: Overview of Therapeutic Effects Page 28: Brain and Neurological Applications Page 29: Antioxidant Benefits Photobiomodulation (PBM) Light Studies (Pages 29–31) Page 29: Mechanisms and Applications Page 30: Dermatological and Aesthetic Uses Page 30: Neurological and Anti-Inflammatory Benefits Micro-Impact Plate (LLMS) Studies (Page 31-32)

Page 31: Bone and Skeletal Benefits Page 31: Pain and Joint Recovery Page 32: Clinical Applications

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Stem Cell Research Studies Longevity 1. Study: "Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting." o Findings: This study explores the mechanisms of MSC aging and identifies markers associated with their senescence. It also discusses strategies to rejuvenate aged MSCs, thereby enhancing their regenerative potential and contributing to increased healthspan and longevity. o Source: PubMed 2. Study: "A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies." o Findings: The research provides a comprehensive framework for understanding MSC aging, including intrinsic and extrinsic factors leading to senescence. It emphasizes the importance of developing innovative approaches to rejuvenate senescent MSCs, which could improve their therapeutic efficacy and promote longevity. o Source: PubMed 3. Study: "Application of mesenchymal stem cells for anti-senescence and clinical challenges." o Findings: This study reviews the potential of MSCs in combating aging- related diseases. It highlights their role in tissue regeneration and discusses clinical challenges, suggesting that MSC-based therapies could be effective in alleviating or curing senescence-related disorders, thereby enhancing longevity. o Source: PubMed 4. Study: "Recent clinical trials with stem cells to slow or reverse normal aging processes." o Findings: The article examines various clinical trials utilizing MSC interventions aimed at slowing or reversing normal aging processes. It discusses the decline in regenerative potential of stem cells with age and evaluates the efficacy of MSC therapies in promoting longevity.

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o Source: PubMed 5. Study: "Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair." o Findings: MSCs support tissue repair and regeneration, enhancing healthspan and longevity.

Source: PubMed

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Anti-Aging 1. Study: "Stem cell therapy and anti-aging: Current evidence and future perspectives."

o Findings: Mesenchymal stem cells (MSCs) have been shown to reduce oxidative stress and inflammation, which are key drivers of aging. MSCs also promote collagen production, improve skin elasticity, and enhance tissue repair, contributing to anti-aging effects in the skin and other tissues. Source: PubMed 2. Study: "Adipose-derived stem cells improve skin elasticity and hydration in aging patients." o

o Findings: Adipose-derived stem cells (ADSCs) were injected

intradermally to treat aging skin. The study reported increased dermal thickness, improved hydration, and reduced wrinkle depth, showing significant rejuvenation effects. Source: PubMed 3. Study: "Exosome-mediated skin rejuvenation: A novel approach in stem cell therapy." o o Findings: Stem cell-derived exosomes applied to the skin enhanced fibroblast activity, increased collagen production, and improved skin texture. This study highlights the potential of stem cell-derived exosomes as a non-invasive treatment for aging skin.

Source: PubMed

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4. Study: "Applications of Stem Cell Therapy and Adipose-Derived Stem Cells for Skin Repair." o Findings: Adipose-derived stem cells (ADSCs) are effective for skin repair due to their ability to reduce inflammation, enhance tissue regeneration, and promote vascular reconstruction. They support collagen production and the regeneration of skin structures, aiding in wound healing and treating skin damage. o Source: PubMed 5. Study: "Adipose-derived stem cells in immune-related skin disease: a review of current research and underlying mechanisms." o Findings: Findings show ADSCs effectively reduce inflammation, regulate immune responses, and promote tissue repair, particularly in conditions like psoriasis and atopic dermatitis. The study highlights their therapeutic potential with minimal side effects, emphasizing their ability to restore skin integrity and balance immune function. o Source: PubMed 6. Study: "Adipose-derived Stem Cells and their Secretory Factors for Skin Aging." o Findings: The study highlights that adipose-derived stem cells (ADSCs) and their secretory factors combat skin aging by reducing oxidative stress, promoting collagen production, enhancing skin elasticity, and supporting tissue repair. These effects help improve skin structure and reduce aging signs effectively.

Source: PubMed

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Wrinkles/Sagging Skin 1. Study: "The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration" (2024) o Findings: This study explores how mesenchymal stem cells (MSCs) stimulate fibroblast activity, leading to increased collagen production and improved skin elasticity and thickness in aging skin.

o Source: Journal of Dermatological Science

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2. Study: "Effects of Adipose-Derived Stem Cells on Wrinkles" (2015)

o Findings: ADSCs improve skin texture, reduce wrinkles, and enhance hydration, demonstrating a reversal of aging signs. o Source: Plastic and Reconstructive Surgery 3. Study: "Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors" o Findings: This study examines how human adipose-derived stem cells (hADSCs) enhance skin quality through paracrine effects. The findings suggest that hADSCs improve collagen production and skin elasticity, leading to a reduction in wrinkles and sagging.

Source: PubMed

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Menopause 1. Study: "Stem cell therapy may help reverse effects of premature menopause, restore fertility" (2018) o Findings: (MSCs) may partially restore ovarian function and alleviate menopause symptoms such as hormonal imbalances. o Source: Endocrine Society 2. Study: "Stem cell-based therapeutic potential in female ovarian aging and infertility" (2024) o Findings: This study examines how MSCs can alleviate menopausal symptoms by regenerating urogenital tissues and balancing hormonal levels Source: Stem cell- based therapeutic potential in female ovarian aging and infertility 3. Study: "Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects" (2022) o o Findings: MSCs helps restore hormone production, improving mood, sleep, and overall well-being in menopausal women.

Source: PubMed

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Osteoporosis 1. Study: " Stem cells in Osteoporosis: From Biology to NewTherapeutic Approaches" (2019) o Findings: The study shows mesenchymal stem cells (MSCs) as a promising therapy for osteoporosis, enhancing bone density by promoting bone formation and reducing resorption. MSCs balance osteoblast and osteoclast activity, improving bone regeneration. o Source: Wiley Online Library 2. Study: "Bone regeneration in osteoporosis: opportunities and challenges" (2022)

o Findings: The study highlights challenges in osteoporotic bone

regeneration, emphasizing the potential of biomaterials, stem cells, and growth factors to improve outcomes. Advanced therapies targeting bone remodeling pathways show promise for effective repair in osteoporosis.

o Source: Springer Nature 3. Study: "Mesenchymal stem cell therapy for osteoporosis: a review." o Findings: MSCs promote osteoblast differentiation, improving bone density and treating osteoporosis. o Source: BMC Osteoporosis-Related Fractures 1. Study: "Revolutionizing bone defect healing: the power of mesenchymal stem cells as seeds” o Findings: MSCs promote bone healing by migrating to fracture sites, where they differentiate into osteoblasts and support tissue regeneration. They enhance bone growth and collagen formation, speeding up repair in osteoporosis-related fractures.

Source: Frontiers

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Cognitive Decline 1. Study: “Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders" (2021) o Findings: MSCs protect neurons, promote neurogenesis, reduce brain inflammation, and enhance memory function in aging models. o Source: MDPI 2. Study: "Intravenous Stem Cell Therapy for Age-Related Cognitive Decline" (2019) o Findings: MSC infusions improve memory, reduce neuroinflammation, and enhance cognitive performance in clinical trials.

o Source: Journal of Neuroinflammation

3. Study: "Intravenous infusion of mesenchymal stem cells improves cognitive function and reduces amyloid-beta deposition in a transgenic mouse model of Alzheimer's disease." o Findings: MSCs improve cognitive function and reduce pathological features of Alzheimer's disease.

Source: Frontiers

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Hearing Loss 1. Study: "Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes." o Findings: MSCs repair cochlear cells, improving auditory function after damage or degeneration.

o Source: The American Journal of Pathology

Cataracts & AMD

• Study: "Mesenchymal stem cells promote the retinal ganglion cell survival and axon regeneration after optic nerve injury." o Findings: MSCs help protect and regenerate retinal cells, showing promise for AMD and cataracts. Source: PubMed

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Hair Loss 1. Study: "Stem Cells and Hair Follicle Regeneration" (2018)

o Findings: ADSCs regenerate hair follicles and promote new hair growth in androgenetic alopecia patients.

o Source: Stem Cells and Development 2. Study: "Autologous Stem Cell Therapy for Hair Regrowth" (2019)

o Findings: Autologous stem cell injections result in significant hair regrowth, promoting follicle regeneration and improved hair density. o Source: International Journal of Trichology 3. Study: "Human adipose-derived stem cells improve hair density and thickness in patients with androgenetic alopecia." o Findings: MSCs promote hair follicle regeneration, improving hair growth and thickness.

Source: PubMed

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Heart Disease 1. Study: "MSC Therapy for Ischemic Heart Disease: A Clinical Trial" (2016) o Findings: MSCs improve cardiac function and reduce scar tissue in ischemic heart disease patients, promoting cardiac repair. o Source: Global Heart Journals 2. Study: "Stem cell therapy for heart failure in the clinics: new perspectives in the era of precision medicine and artificial intelligence" (2024) o Findings: SC therapy, combined with precision medicine and AI, improves treatment outcomes for heart failure. Source: PubMed 3. Study: "Intracoronary infusion of mesenchymal stem cells and effects on left ventricular function in patients with chronic heart failure." o o Findings: MSCs improve cardiac function and reduce scarring in chronic heart failure.

Source: AHA Journals

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Musculoskeletal Issues 1. Study: "Mesenchymal stem cell therapy in musculoskeletal disorders: a review."

o Findings: MSCs promote tissue repair and reduce inflammation in musculoskeletal conditions.

Source: PubMed

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Chronic Pain 1. Study: "Biologic Therapy in Chronic Pain Management " (2021)

o Findings: MSCs reduce chronic musculoskeletal pain by modulating immune response and inflammation, improving mobility. Source: Pain Medicine Journal 2. Study: "Stem Cell Therapy for Chronic Pain Management: Review" (2017) o o Findings: SC therapy offers hope for chronic pain relief by regenerating tissue and reducing inflammation. Source: Journal of Pain Research 3. Study: "Mesenchymal stem cell transplantation modulates pain behavior in a rat model of neuropathic pain." o o Findings: MSCs alleviate chronic pain by modulating inflammatory responses and promoting tissue repair.

Source: Frontiers

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Arthritis 1. Study: "Stem Cell Therapy in Osteoarthritis: A Meta-Analysis" (2019)

o Findings: MSC therapy reduces inflammation, promotes cartilage regeneration, and improves joint function in osteoarthritis patients. o Source: Stem Cells Translational Medicine 2. Study: "The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment" (2022) o Findings: The study shows that mesenchymal stem cells (MSCs) and their exosomes promote tissue repair, reduce inflammation, and aid bone and cartilage regeneration in orthopedic conditions like osteoarthritis and osteoporosis.

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o Source: Arthritis Research & Therapy 3. Study: "Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis: a systematic review of clinical outcomes." o Findings: MSCs reduce pain, improve joint function, and enhance cartilage repair in osteoarthritis.

o Source: PubMed Tendon/Ligament Injuries 1. Study: "Stem Cell-Based Therapies for Tendon Repair"

o Findings: ADSCs accelerate tendon healing, enhance strength, and prevent re-injury in athletes. o Source: Stem Cell-Based Therapies for Tendon Repair 2. Study: "Role of tendon-derived stem cells in tendon and ligament repair: focus on tissue engineer" (2024)

o Findings: Tendon-derived stem cells (TDSCs) aid in tendon and ligament repair by differentiating into necessary cell types.

o Source: Frontiers 3. Study: "Mesenchymal stem cell therapy for tendon repair: a systematic review." o Findings: MSCs enhance healing and functional recovery in tendon and ligament injuries.

Source: PubMed

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Joint Issues 1. Study: "Mesenchymal stem cells in osteoarthritis therapy: a review"

o Findings: MSCs help repair damaged cartilage and reduce inflammation in joints. They support cartilage regeneration and may improve joint function.

o Source: PubMed 2. Study: "Strategies for Articular Cartilage Repair and Regeneration"

o Findings: MSCs can repair cartilage by differentiating into chondrocytes when exposed to mechanical and hypoxic conditions.

Source: Frontiers

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3. Study: "Mesenchymal stem cell therapy for joint diseases: a review of clinical applications." o Findings: MSCs reduce joint pain and improve cartilage regeneration in degenerative joint disorders.

o Source: Journal of Bone and Joint Surgery

Spinal Disc Degeneration 1. Study: "Stem Cell Therapy for Degenerative Disc Disease" (2017)

o Findings: MSC injections increase disc height, regenerate disc tissue, and reduce pain in degenerative disc disease patients. Source: PubMed 2. Study: "Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration" (2018) o o Findings: MSC therapy slows disc degeneration and restores disc integrity in preclinical and ongoing clinical trials. Source: Wiley Online Library 3. Study: "Mesenchymal stem cell transplantation in intervertebral disc degeneration: a systematic review" (2022) o

o Findings: MSCs repair intervertebral discs, reducing pain and improving spinal mobility.

Source: PubMed

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Sports Injuries 1. Study: "MSC-Based Treatment of Sports-Related Cartilage Injuries" (2016) o Findings: MSC therapy improves cartilage repair, reduces pain, and enhances recovery time in athletes with cartilage injuries. o Source: British Journal of Sports Medicine 2. Study: "Emerging Applications of Stem Cell and Regenerative Medicine to Sports Injuries” (2014) o Findings: MSC can accelerate recovery by promoting tissue regeneration, reducing inflammation, and healing tendons, ligaments, and cartilage.

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o Source: PubMed 3. Study: "Mesenchymal Stem Cells for Treatment of Tendon and Ligament Injuries-clinical Evidence" (2020)

o Findings: MSCs accelerate recovery from ligament, tendon, and muscle injuries, enhancing tissue repair.

Source: PubMed

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Metabolic Disorders 1. Study: "Therapeutic potential of MSCs in treating metabolic syndrome and related disorders." o Findings: MSCs reduce inflammation, improve insulin sensitivity, and ameliorate metabolic abnormalities.

Source: Oxford Academic

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Type II Diabetes 1. Study: "Advances and challenges of the cell-based therapies among diabetic patients" (2024) o Findings: MSCs regenerate pancreatic beta cells, improving insulin secretion and glucose tolerance. o Source: Diabetes Care Journal 2. Study: "Stem Cell Therapy in Treating Diabetic Complications" (2018) o Findings: MSC therapy reduces insulin resistance, systemic inflammation, and improves glycemic control in diabetic patients. o Source: Diabetes Care Journal 3. Study: "Stem Cell Therapy: Success and Continuing Progress in Treating Diabetes" (2018) o Findings: Adipose-derived MSCs significantly lower HbA1c levels and reduce insulin requirements, showing promise in managing diabetes.

o Source: Clin Med International Library

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4. Study: "Mesenchymal stem cell therapy in type 2 diabetes mellitus: a systematic review." o Findings: MSCs enhance pancreatic function, regulate blood glucose, and reduce systemic inflammation.

Source: PubMed

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Obesity 1. Study: "Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment" (2023) o Findings: ADSCs show promise in treating obesity and related metabolic disorders by improving metabolism, reducing inflammation, and regenerating fat tissue. o Source: MDPI 2. Study: "Adipose-Derived Stem Cells, Obesity, and Inflammation" (2022) o Findings: (ADSCs) help reduce obesity-related inflammation and aid in osteoarthritis treatment by promoting tissue repair and cartilage regeneration. o Source: PubMed 3. Study: "Stem Cell Therapy for Obesity and Metabolic Syndrome" (2016) o Findings: MSC can potentially treat metabolic syndrome by reducing inflammation, regulating fat cell formation, and improving insulin resistance. Source: Wiley Online Library 4. Study: "Adipose-derived mesenchymal stem cells improve insulin sensitivity in obesity." o o Findings: MSCs reduce inflammation and improve metabolic function in obese individuals. o Source: JCEM Reproductive & Sexual Wellness 1. Study: "Mesenchymal stem cells in reproductive medicine: current applications and future directions."

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o Findings: MSCs improve ovarian function, sperm quality, and hormonal balance, enhancing reproductive health.

Source: Oxford Academic

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Erectile Dysfunction 1. Study: "Potential of Adipose‐Derived Stem Cells for Treatment of Erectile Dysfunction" (2009) o Findings: ADSCs improve erectile function by regenerating blood vessels and increasing penile blood flow. o Source: The Journal Of Sexual Medicine 2. Study: "Mesenchymal Stem Cell Therapy for Erectile Dysfunction Due to Diabetes" (2017) o Findings: MSC therapy regenerates nerves and blood vessels, improving erectile function in diabetic patients with ED. o Source: Stem Cells Translational Medicine 3. Study: "Intracavernous injection of MSCs improves erectile function in a diabetic rat model." o Findings: MSCs repair vascular damage, improving erectile function and blood flow.

o Source: The Journal Of Sexual Medicine

Libido Decline 1. Study: "Enhancing Sexual Health with Stem Cell Therapy: Results from the ACESO & CERES Trials in Diabetes and Metabolic Syndrome" (2022) o Findings: MSC infusion therapy improved sexual function, libido, and hormonal balance in both men and women with metabolic issues. o Source: The Journal Of Sexual Medicine 2. Study: "Hormonal Regulation and Stem Cell Therapy for Libido Decline" (2022) o Findings: MSCs positively influence testosterone and estrogen levels, enhancing sexual desire and performance. o Source: Frontiers

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3. Study: "Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction . " o Findings: MSCs may improve sexual function in aging individuals by restoring hormonal balance and enhancing reproductive health.

Source: Frontiers

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Endometriosis 1. Study: "Mesenchymal stem cells reduce inflammation and improve tissue remodeling in endometriosis." o Findings: MSCs suppress inflammation and alleviate symptoms of endometriosis.

o Source: Journal of Biological Engineering

Chronic Venous Insufficiency & Varicose Veins 1. Study: "Stem cell therapy for vascular disorders: potential applications in venous insufficiency."

o Findings: MSCs enhance vascular repair, reducing symptoms of venous insufficiency.

Source: ScienseDirect

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Peripheral Neuropathy 1. Study: "Mesenchymal stem cells improve nerve function in diabetic peripheral neuropathy."

o Findings: MSCs promote nerve repair and alleviate neuropathic pain.

o Source: ScienseDirect Balance Disorders & Fall Prevention 1. Study: "MSC therapy for vestibular dysfunction: potential to improve balance."

o Findings: MSCs restore vestibular function and reduce fall risk in balance disorders.

Source: Cell Report

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Hypothyroidism 1. Study: "MSC transplantation for hypothyroidism: preclinical evidence." o Findings: MSCs reduce autoimmune attacks on thyroid tissue, improving thyroid function and restoring hormonal balance. o Source: PubMed 2. Study: "Stem Cells for Regulating Thyroid Function in Autoimmune Hypothyroidism."

o Findings: MSCs modulate the immune response in autoimmune thyroiditis, promoting thyroid tissue repair.

Source: PubMed

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Hyperthyroidism 1. Study: "Insight Into Mouse Models of Hyperthyroidism."

o Findings: MSCs reduce thyroid overactivity, modulate immune function, and alleviate hyperthyroid symptoms.

Source: Frontiers

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Cushing's Syndrome 1. Study: "MSC-based treatments in endocrine disorders: potential applications in Cushing's syndrome."

o Findings: MSCs regulate hormonal imbalances, reduce systemic inflammation, and alleviate symptoms of Cushing's syndrome.

o Source: Journal of Clinical Endocrinology & Metabolism

Addison's Disease 1. Study: "MSC transplantation for adrenal insufficiency in Addison's disease: mechanisms and outcomes."

o Findings: MSCs improve adrenal function, modulate immune responses, and restore hormonal balance in Addison's disease.

Link: PubMed

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Hyperparathyroidism 1. Study: "Hypoparathyroidism: State of the Art on Cell and Tissue Therapies." o Findings: MSCs regulate parathyroid hormone levels, reduce bone loss, and promote bone repair in hyperparathyroidism.

Source: PubMed

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Hypoparathyroidism 2. Study: "MSC transplantation for hypoparathyroidism: preclinical and clinical evidence."

o Findings: MSCs promote calcium balance, improve parathyroid function, and alleviate symptoms in hypoparathyroidism.

Source: Frontiers

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3. Study: "Mesenchymal stem cells for hypoparathyroidism: a novel treatment strategy." o Findings: MSCs restore calcium homeostasis and support parathyroid gland repair.

Source: MDPI

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Eczema 1. Study: " T herapeutic Potential and Mechanisms of MSCs and Their Extracellular Vesicles in Atopic Dermatitis." (2024) o Findings: MSCs and their extracellular vesicles show promise in treating atopic dermatitis by reducing inflammation and modulating immune responses.

o Source: Journal of Inflammation Research

Chronic Sinusitis 1. Study: "MSC therapy for chronic rhinosinusitis: inflammation modulation and tissue repair."

o Findings: MSCs reduce sinus inflammation, promote tissue regeneration, and alleviate chronic symptoms.

o Source: Stem Cell Research & Therapy

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Sarcoidosis 1. Study: "Cellular Therapy Could Soothe Sarcoidosis"

o Findings: MSCs may modulate immune responses and reduce inflammation in sarcoidosis, offering a potential therapeutic approach.

o Source: NIH Intramural Research Program

Polycystic Ovary Syndrome (PCOS) 1. Study: "MSC therapy for polycystic ovary syndrome: emerging evidence." o Findings: MSCs improve ovarian function, regulate hormones, and reduce inflammation in PCOS patients.

Source: MDPI

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Epilepsy 1. Study: "The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives.” o Findings: MSCs protect neurons, reduce seizure frequency, and modulate neuroinflammation in epilepsy.

o Source: Journal of Translational Medicine

Hypoxic-Ischemic Encephalopathy (HIE) 1. Study: "MSC therapy for neonatal hypoxic-ischemic encephalopathy: outcomes and mechanisms."

o Findings: MSCs reduce neuronal damage, promote repair, and improve outcomes in HIE.

Source: PubMed

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Heavy Metals 1. Study: "Challenges of mesenchymal stem cells in the clinical treatment of COVID-19" o Findings: The study discusses MSCs' potential in reducing oxidative stress and promoting tissue repair, which may be applicable to heavy metal toxicity.

o Source: Cell and Tissue Research

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Radiation 1. Study: " The Main Mechanisms of Mesenchymal Stem Cell-Based Therapy in Treating COVID-19" o Findings: MSCs' regenerative properties and ability to mitigate inflammation suggest potential in treating radiation-induced injuries

o Source: Cellular and Molecular Bioengineering

Drug-Related 1. Study: "MSC therapy in toxicology: therapeutic effects in radiation and heavy metal exposure." o Findings: MSCs reduce oxidative stress, detoxify tissues, and repair damage from radiation or heavy metals. o Source: PubMed COPD (Chronic Obstructive Pulmonary Disease) 1. Study: "Intravenous MSCs improve lung function in patients with COPD: a pilot trial." o Findings: MSCs reduce inflammation and improve respiratory function and quality of life in COPD patients.

o Source: Stem Cell Research & Therapy

Long-COVID 1. Study: "Mesenchymal stem cells for post-COVID lung syndrome: clinical evidence."

o Findings: MSCs repair lung tissue and reduce inflammation in patients with Long-COVID.

o Source: Journal of Translational Medicine

Asthma 1. Study: "MSC-based therapy reduces airway inflammation in allergic asthma." o Findings: MSCs improve airway function and reduce inflammation in asthma patients.

o Source: Stem Cell Research & Therapy

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Kidney Disease 1. Study: "MSC therapy for chronic kidney disease: mechanisms of repair."

o Findings: MSCs enhance renal function, reduce fibrosis, and modulate immune responses in chronic kidney disease.

o Source: Stem Cell Research & Therapy

Fatty Liver 1. Study: "MSC transplantation reduces hepatic inflammation in non-alcoholic fatty liver disease." o Findings: MSCs repair liver tissue, reduce fat deposition, and improve liver function.

o Source: Stem Cell Research & Therapy

Cirrhosis 1. Study: "MSC therapy for liver cirrhosis: clinical outcomes."

o Findings: MSCs promote liver regeneration, reduce fibrosis, and improve hepatic function in cirrhosis patients.

o Source: Frontiers in Cell and Developmental Biology

Diabetic Foot 1. Study: "Mesenchymal stem cell therapy for diabetic foot ulcers: a meta- analysis."

o Findings: MSCs accelerate wound healing, improve vascularization, and reduce complications in diabetic foot ulcers.

Source: PubMed

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Wound Healing 1. Study: "MSC therapy for chronic wounds: clinical and preclinical evidence." o Findings: MSCs enhance tissue regeneration and improve healing rates in chronic wounds.

o Source: Stem Cell Research & Therapy

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Alzheimer's Disease 1. Study: "Mesenchymal stem cells reduce amyloid-beta and improve cognitive function in Alzheimer's models." o Findings: MSCs reduce amyloid plaques, protect neurons, and improve cognitive function.

o Source: Stem Cell Research & Therapy

Parkinson's Disease 1. Study: "MSCs improve dopaminergic neuron survival and motor function in Parkinson's models." o Findings: MSCs reduce inflammation, enhance neuronal survival, and improve motor symptoms in Parkinson's disease.

Source: PubMed

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Multiple Sclerosis (MS) 1. Study: "Mesenchymal Stem Cell Therapy in Multiple Sclerosis: A Systematic Review and Meta-Analysis" o Findings: MSC therapy for MS improved motor and sensory functions, helping reduce disability and slow disease progression.

Source: MDPI

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Stroke Recovery 1. Study: "Mesenchymal stem cell therapy in ischemic stroke: neuroprotective and regenerative effects." o Findings: MSCs reduce inflammation, promote neurogenesis, and improve functional recovery after a stroke.

• Source: Stem Cell Research & Therapy

ALS (Amyotrophic Lateral Sclerosis) 1. Study: "MSC transplantation slows ALS progression and improves motor neuron survival."

o Findings: MSCs reduce neuroinflammation and oxidative stress, slowing disease progression and improving functional outcomes in ALS patients.

© 2024 Longevity Medical Institute. All rights reserved.

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Source: ALS News Today

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Spinal Cord Injuries 1. Study: "MSC therapy promotes axonal regeneration and functional recovery in spinal cord injuries."

o Findings: MSCs support tissue repair, reduce scarring, and improve motor function in spinal cord injuries.

Source: PubMed

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Crohn's Disease 1. Study: "MSC therapy for perianal fistulas in Crohn's disease: clinical applications."

o Findings: MSCs promote fistula closure, reduce inflammation, and improve intestinal healing in Crohn's disease.

o Link: Stem Cell Research & Therapy

Ulcerative Colitis 1. Study: "Mesenchymal stem cells reduce inflammation and promote mucosal healing in ulcerative colitis." o Findings: MSCs improve mucosal integrity, reduce disease activity, and promote tissue regeneration in ulcerative colitis patients.

o Source: Stem Cell Research & Therapy

Rheumatoid Arthritis (RA) 1. Study: "MSC transplantation reduces joint inflammation and preserves cartilage in rheumatoid arthritis."

o Findings: MSCs reduce inflammation, promote cartilage repair, and improve joint mobility in rheumatoid arthritis.

o Source: Stem Cell Research & Therapy

Lupus (SLE) 1. Study: "MSC-based therapies for systemic lupus erythematosus:"

o Findings: MSCs suppress immune overactivity, reduce disease severity, and improve organ function in lupus patients.

o Source: Stem Cell Research & Therapy

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Psoriasis 1. Study: "MSC therapy reduces inflammation and improves skin lesions in psoriasis." o Findings: MSCs enhance skin repair, reduce psoriatic plaques, and improve quality of life for patients with psoriasis.

o Source: Stem Cell Research & Therapy

HBOT Research Studies Hyperbaric Oxygen Therapy (HBOT) 1. Study: "Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial." o Findings: HBOT increased telomere length and reduced senescent cells in healthy aging adults, highlighting its potential anti-aging benefits. o Source: Aging-US 2. Study: "Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients—a retrospective analysis." o Findings: HBOT improved cognitive functions such as memory and attention in post-stroke patients, aiding neurological recovery. o Source: Restorative Neurology and Neuroscience 3. Study: "Hyperbaric oxygen therapy can diminish fibromyalgia syndrome— prospective clinical trial." o Findings: HBOT significantly reduced pain and enhanced quality of life for fibromyalgia patients. o Source: PLOS ONE 4. Study: "Hyperbaric oxygen therapy for traumatic brain injury: a systematic review of the literature." o Findings: HBOT improved outcomes in patients with traumatic brain injury, including reduced mortality and better neurological recovery.

Source: Medical Gas Research

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5. Study: "Hyperbaric oxygen therapy for radiation-induced late side effects in normal tissues." o Findings: HBOT promoted healing in tissues damaged by late radiation side effects, improving quality of life. o Source: W iley Online Library 6. Study: "Hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a systematic review." o Findings: HBOT improved healing rates in diabetic foot ulcers, reducing the risk of major amputations. o Source: Diabetes Care 7. Study: "Hyperbaric oxygen therapy for the treatment of long COVID: early evaluation of a highly promising intervention." o Findings: HBOT alleviated long COVID symptoms, such as fatigue and cognitive impairments, in preliminary studies. o Source: Frontiers in Medicine 8. Study: "Hyperbaric oxygen therapy for the treatment of post-traumatic stress disorder associated with traumatic brain injury." o Findings: HBOT reduced symptoms of PTSD, including anxiety and depression, in affected individuals. o Source: DovePress 9. Study: "Hyperbaric oxygen therapy in the management of chronic wounds: a systematic review." o Findings: HBOT enhanced healing in chronic wounds, such as pressure ulcers and venous leg ulcers. o Source: International Wound Journal 10. Study: "Hyperbaric oxygen therapy in sports injuries: enhancing recovery and performance." o Findings: HBOT accelerated recovery from sports-related injuries by reducing inflammation, promoting tissue repair, and improving oxygenation in damaged tissues.

Source: SagePub

o

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11. Study: "Hyperbaric Oxygen Therapy for Acute Ischemic Stroke."

o Findings: HBOT improved neurological outcomes and reduced mortality in ischemic stroke patients. Source: Stroke Molecular Hydrogen Inhalation Studies 1. Study: "Molecular Hydrogen Therapy—A Review on Clinical Studies and Future Perspectives" o o Findings: This review highlights the antioxidant properties of hydrogen gas and its therapeutic effects in conditions such as cardiovascular diseases, cancer, respiratory diseases, neurological disorders, and infections. It also discusses challenges in hydrogen administration and potential future technologies. Source: MDPI 2. Study: "Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders" o o Findings: The study explores hydrogen gas inhalation as a therapeutic method for brain disorders. It emphasizes the safety and practicality of hydrogen inhalation and hydrogen-rich water for both treatment and prevention. Source: Springer 3. Study: "Case Report on a Novel Application of Molecular Hydrogen Inhalation Therapy for Parkinson's Disease and Persistent Post-Concussive Syndrome" o o Findings: This case report demonstrates significant neurological improvements in a patient with Parkinson's disease and post- concussive syndrome following hydrogen gas inhalation therapy. The study suggests hydrogen's potential in reducing inflammation, oxidative stress, and improving vascular function.

Source: Hue Light USA

o

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4. Study: "Molecular Hydrogen: From Molecular Effects to Stem Cells Applications"

o Findings: This review examines hydrogen gas administration through various methods (inhalation, water, saline) and highlights its antioxidant properties and potential applications in stem cell-based therapies and disease treatments.

o Source: MDPI 5. Study: "Hydrogen - An Emerging Medical Gas"

o Findings: This article reviews hydrogen's role as a medical gas, focusing on its unique antioxidant capabilities and applications in conditions such as inflammation, neurodegeneration, and metabolic syndromes.

o Source: Molecular Hydrogen Institute Photobiomodulation (PBM) Light Studies 1. Study: "Photobiomodulation—Underlying Mechanism and Clinical Applications"

o Findings: This review outlines the mechanisms of PBM, including its effects on mitochondrial function and cellular signaling, and explores its applications in medicine and dentistry.

o Source: PMC 2. Study: "Red Light Therapy: Effectiveness, Treatment, and Risks"

o Findings: Highlights the effectiveness of red light therapy for treating acne, wrinkles, and pain while discussing its benefits and potential risks. Source: WebMD 3. Study: "Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review" o o Findings: Explores the combined use of PBM with other therapies for neurological and neuropsychiatric disorders, demonstrating enhanced outcomes.

Source: BMC Neurology

o

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4. Study: "Advances in photobiomodulation for cognitive improvement by near- infrared light" o Findings: Examines the use of near-infrared light PBM to improve cognitive functions, suggesting potential for neurorehabilitation. o Source: Translational Medicine 5. Study: "Photobiomodulation efficacy in age-related macular degeneration: a systematic review and meta-analysis" o Findings: Demonstrates PBM's effectiveness in managing dry age- related macular degeneration, showing potential to halt or reverse disease progression. o Source: Journal of Retina & Vitreous 6. Study: "Photobiomodulation: The Clinical Applications of Low-Level Light Therapy" o Findings: Reviews PBM's applications in aesthetic medicine, including skin rejuvenation and treatment of various skin conditions. o Source: Aesthetic Surgery Journal 7. Study: "Improvements in clinical signs and symptoms of Parkinson's disease following photobiomodulation: a long-term study" o Findings: Reports significant improvements in both motor and non- motor symptoms in Parkinson's disease patients following long-term PBM therapy. o Source: BMC Neurology 8. Study: "Mechanisms and applications of the anti-inflammatory effects of photobiomodulation" o Findings: Explores PBM's anti-inflammatory mechanisms and its applications in treating inflammatory conditions across various systems. Source: AIMS Biophysics 9. Study: "Transcranial low-level laser stimulation in near infrared-II region for brain safety and protection" o o Findings: Investigates the neuroprotective effects and safety of transcranial PBM using near-infrared light, suggesting benefits for brain health.

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o Source: arXiv 10. Study: "Activating Brain-Gut Connection with Light Reduces Depression" o Findings: Explores how PBM targeting the brain-gut axis can alleviate symptoms of depression, highlighting its potential in mental health.

Source: Neuroscience News

o

Micro-Impact Plate (LLMS) Studies 1. Study: "Juvent's Micro-Impact Platform for Increasing Bone Mineral Density in Pediatric Cancer Survivors"

o Findings: This randomized, placebo-controlled clinical study

demonstrated that Micro-Impact Therapy effectively improved total body and tibial bone mineral density (BMD) in pediatric cancer survivors. Participants who completed 70% or more of the prescribed sessions experienced a mean increase of 11.2% in tibial trabecular BMD. Source: Juvent Health Research 2. Study: "Human Health Benefits of Low Magnitude Mechanical Stimulation (LMMS)" o o Findings: This review discusses the anabolic effects of LMMS on the skeletal system, highlighting its role in stimulating mesenchymal stem cells toward osteoblastogenesis. Clinical studies have shown that LMMS improves pain, balance, gait quality, and inflammatory markers in elderly subjects with knee osteoarthritis. Source: Juvent Health Research 3. Study: "Differentiating Human Health Benefits: Micro-Impact Therapy vs. Whole Body Vibration" o o Findings: This paper compares Micro-Impact Therapy with Whole Body Vibration, emphasizing the safety and efficacy of low-magnitude mechanical stimulation in promoting bone health and reducing the risk of low back pain associated with high-magnitude vibrations.

Source: Juvent Health Research

o

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4. Study: "Effect of Low-Intensity Vibration on Bone Strength"

o Findings: This prospective, randomized, double-blinded, 12-month study evaluated the impact of low-intensity vibration on bone strength, indicating potential benefits in enhancing bone density and structural integrity. o Source: Center for Skeletal Research 5. Study: "Clinical Trial Confirms New Device Improves Bone Density in Cancer Survivors" o Findings: A clinical trial confirmed that the use of a Micro-Impact Platform significantly improved bone density in cancer survivors, offering a non-invasive intervention to address bone loss associated with cancer treatments.

o Source: GlobeNewswire Vagal Nerve Stimulation Studies 1. Study: "Vagus Nerve Stimulation Relieves Severe Depression"

o Findings: A national clinical trial led by Washington University School of Medicine in St. Louis found that vagus nerve stimulation (VNS) significantly improved depressive symptoms, quality of life, and daily functioning in patients with severe, treatment-resistant depression.

o Source: Washington University School of Medicine News

2. Study: “ Chronic Insomnia”

o Findings: A recent trial demonstrated that transcutaneous auricular VNS is safe and effective for treating chronic insomnia, offering a potential non-pharmacological treatment option.

o Source: Medscape 3. Study: Inflammatory Bowel Disease (IBD)

o Findings: Emerging research suggests that VNS may help reduce inflammation and alleviate symptoms in patients with IBD, such as ulcerative colitis, by modulating the brain-gut axis.

Source: Time

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Put Your Health First: Reach Out Today It's time to take full control of your health and find healing, restoration and rejuvenation at LMI. As you set out on your path to good health, our expert team is ready to support and care for you every step of the way. If you're ready to begin your journey with us, contact us to schedule your personalized consultation in San José del Cabo, where luxury meets cutting-edge medical care. SMS text us or call us toll-free: 1-833-LMI-CABO Or email us: info@lmiclinic.com Website: www.longevity-institute.com • US office: Longevity Medical Institute LLC., 1244 N Post Oak Rd, Suite 200, Houston TX 77055 • Mexico clinic: Longevity Medical Institute MX, S. de R.L. de C.V., Malecon San Jose 137, Zona Hotelera, 23405 San José del Cabo, B.C.S., Mexico

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