Longevity Medical Institute Research eBook

Discover Longevity Medical Institute in San Jose del Cabo, BCS Mexico for the most comprehensive compilation of stem cell research, featuring the latest studies, breakthroughs, and applications in regenerative medicine.

Research Studies Our comprehensive repository of research studies, accessible to our team and patients, reinforces the evidence-based approach behind each service we offer. Whether it's the proven efficacy of stem cell therapies, the benefits of hyperbaric oxygen therapy, or advancements in photobiomodulation light, LMI remains at the forefront of medical innovation, delivering protocols that are not only state-of-the-art but also rigorously validated by science. This commitment to research empowers us to provide the highest standard of care, ensuring our patients receive therapies that are both transformative and scientifically grounded.

Table of Contents

Stem Cell Research Studies (Pages 5–26)

Longevity

Anti-Aging

Wrinkles/Sagging Skin

Menopause

Osteoporosis and Fractures

Cognitive Decline

Hearing Loss

Cataracts & AMD

Hair Loss

Heart Disease

Musculoskeletal Issues

Chronic Pain

Arthritis

Tendon/Ligament Injuries

Joint Issues

Spinal Disc Degeneration

Sports Injuries

Metabolic Disorders

Type II Diabetes

Obesity

Reproductive & Sexual Wellness

Erectile Dysfunction

Libido Decline

Endometriosis

Chronic Venous Insufficiency & Varicose Veins

Peripheral Neuropathy

Balance Disorders & Fall Prevention

Thyroid Disorders (Hypothyroidism & Hyperthyroidism)

Cushing's Syndrome

Addison's Disease

Parathyroid Disorders (Hyperparathyroidism & Hypoparathyroidism)

Eczema

Chronic Sinusitis

Sarcoidosis

Polycystic Ovary Syndrome (PCOS)

Epilepsy

Hypoxic-Ischemic Encephalopathy (HIE)

Heavy Metals

Radiation

Drug Related

COPD (Chronic Obstructive Pulmonary Disease)

Long-COVID

Asthma

Kidney Disease

Fatty Liver

Cirrhosis

Diabetic Foot

Wound Healing

Alzheimer's Disease

Parkinson's Disease

Multiple Sclerosis (MS)

Stroke Recovery

ALS (Amyotrophic Lateral Sclerosis)

Spinal Cord Injuries

Crohn's Disease

Ulcerative Colitis

Rheumatoid Arthritis (RA)

Lupus (SLE)

Psoriasis

Hyperbaric Oxygen Therapy (HBOT) Research Studies (Pages 41–45)

Anti-Aging and Telomere Lengthening

Cognitive Recovery and Neurological Benefits

Fibromyalgia Syndrome

Traumatic Brain Injury

Radiation-Induced Tissue Damage

Diabetic Foot Ulcers

Long COVID

PTSD Treatment

Chronic Wound Healing

Sports Recovery

Ischemic Stroke

Molecular Hydrogen Inhalation Studies (Pages 45–47)

Overview of Therapeutic Effects

Brain and Neurological Applications

Antioxidant Benefits

Photobiomodulation (PBM) Light Studies (Pages 47–50)

Mechanisms and Applications

Dermatological and Aesthetic Uses

Neurological and Anti-Inflammatory Benefits

Micro-Impact Plate (LLMS) Studies (Page 50-51)

Bone and Skeletal Benefits

Pain and Joint Recovery

Clinical Applications

Stem Cell Research Studies

Longevity

Study:

"Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting."

o Findings: This study explores the mechanisms of MSC aging and identifies markers associated with their senescence. It also discusses strategies to rejuvenate aged MSCs, thereby enhancing their regenerative potential and contributing to increased healthspan and longevity. o Source: PubMed

Study:

"A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies."

o Findings: The research provides a comprehensive framework for understanding MSC aging, including intrinsic and extrinsic factors leading to senescence. It emphasizes the importance of developing innovative approaches to rejuvenate senescent MSCs, which could improve their therapeutic efficacy and promote longevity. o Source: PubMed

Study:

"Application of mesenchymal stem cells for anti-senescence and clinical challenges."

o Findings: This study reviews the potential of MSCs in combating aging-related diseases. It highlights their role in tissue regeneration and discusses clinical challenges, suggesting that MSC-based therapies could be effective in alleviating or curing senescence-related disorders, thereby enhancing longevity. o Source: PubMed

Study:

"Recent clinical trials with stem cells to slow or reverse normal aging processes."

o Findings: The article examines various clinical trials utilizing MSC interventions aimed at slowing or reversing normal aging processes. It discusses the decline in regenerative potential of stem cells with age and evaluates the efficacy of MSC therapies in promoting longevity. o Source: PubMed

Study:

"Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair."

o Findings: MSCs support tissue repair and regeneration, enhancing healthspan and longevity. o Source: PubMed

Anti-Aging

Study:

"Stem cell therapy and anti-aging: Current evidence and future perspectives."

Findings: Mesenchymal stem cells (MSCs) have been shown to reduce oxidative stress and inflammation, which are key drivers of aging. MSCs also promote collagen production, improve skin elasticity, and enhance tissue repair, contributing to anti-aging effects in the skin and other tissues.

Source: PubMed

Study:

"Adipose-derived stem cells improve skin elasticity and hydration in aging patients."

Findings: Adipose-derived stem cells (ADSCs) were injected intradermally to treat aging skin. The study reported increased dermal thickness, improved hydration, and reduced wrinkle depth, showing significant rejuvenation effects.

Source: PubMed

Study:

"Exosome-mediated skin rejuvenation: A novel approach in stem cell therapy."

Findings: Stem cell-derived exosomes applied to the skin enhanced fibroblast activity, increased collagen production, and improved skin texture. This study highlights the potential of stem cell-derived exosomes as a non-invasive treatment for aging skin. Source: PubMed

Study:

"Applications of Stem Cell Therapy and Adipose-Derived Stem Cells for Skin Repair."

Findings: Adipose-derived stem cells (ADSCs) are effective for skin repair due to their ability to reduce inflammation, enhance tissue regeneration, and promote vascular reconstruction. They support collagen production and the regeneration of skin structures, aiding in wound healing and treating skin damage.

Source: PubMed

Study:

"Adipose-derived stem cells in immune-related skin disease: a review of current research and underlying mechanisms."

Findings: Findings show ADSCs effectively reduce inflammation, regulate immune responses, and promote tissue repair, particularly in conditions like psoriasis and atopic dermatitis. The study highlights their therapeutic potential with minimal side effects, emphasizing their ability to restore skin integrity and balance immune function.

Source: PubMed

Study:

"Adipose-derived Stem Cells and their Secretory Factors for Skin Aging."

Findings: The study highlights that adipose-derived stem cells (ADSCs) and their secretory factors combat skin aging by reducing oxidative stress, promoting collagen production, enhancing skin elasticity, and supporting tissue repair. These effects help improve skin structure and reduce aging signs effectively. Source: PubMed

Wrinkles/Sagging Skin

Study:

"The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration" (2024)

Findings: his study explores how mesenchymal stem cells (MSCs) stimulate fibroblast activity, leading to increased collagen production and improved skin elasticity and thickness in aging skin. Source: Journal of Dermatological Science

Study:

"Effects of Adipose-Derived Stem Cells on Wrinkles" (2015)

Findings: ADSCs improve skin texture, reduce wrinkles, and enhance hydration, demonstrating a reversal of aging signs. Source: Plastic and Reconstructive Surgery

Study:

"Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors"

Findings: This study examines how human adipose-derived stem cells (hADSCs) enhance skin quality through paracrine effects. The findings suggest that hADSCs improve collagen production and skin elasticity, leading to a reduction in wrinkles and sagging. Source: Journal of Dermatological Science

Menopause

Study:

"Stem cell therapy may help reverse effects of premature menopause, restore fertility" (2018)

Findings: (MSCs) may partially restore ovarian function and alleviate menopause symptoms such as hormonal imbalances. Source: Endocrine Society

Study:

"Stem cell-based therapeutic potential in female ovarian aging and infertility" (2024)

Findings: This study examines how MSCs can alleviate menopausal symptoms by regenerating urogenital tissues and balancing hormonal levels Source: Stem cell-based therapeutic potential in female ovarian aging and infertility

Study:

"Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects" (2022)

Findings: MSCs helps restore hormone production, improving mood, sleep, and overall well-being in menopausal women. Source: PubMed

Osteoporosis

Study:

Stem cells in Osteoporosis: From Biology to NewTherapeutic Approaches" (2019)

Findings: The study shows mesenchymal stem cells (MSCs) as a promising therapy for osteoporosis, enhancing bone density by promoting bone formation and reducing resorption. MSCs balance osteoblast and osteoclast activity, improving bone regeneration. Source: Wiley Online Library

Study:

"Bone regeneration in osteoporosis: opportunities and challenges" (2022)

Findings: The study highlights challenges in osteoporotic bone regeneration, emphasizing the potential of biomaterials, stem cells, and growth factors to improve outcomes. Advanced therapies targeting bone remodeling pathways show promise for effective repair in osteoporosis. Source: Springer Nature

Study:

"Mesenchymal stem cell therapy for osteoporosis: a review."

Findings: MSCs promote osteoblast differentiation, improving bone density and treating osteoporosis. Source: BMC

Osteoporosis-Related Fractures

Study:

"Revolutionizing bone defect healing: the power of mesenchymal stem cells as seeds”

Findings: MSCs promote bone healing by migrating to fracture sites, where they differentiate into osteoblasts and support tissue regeneration. They enhance bone growth and collagen formation, speeding up repair in osteoporosis-related fractures. Source: Frontiers

Cognitive Decline

Study:

“Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders" (2021)

Findings: MSCs protect neurons, promote neurogenesis, reduce brain inflammation, and enhance memory function in aging models. Source: MDPI

Study:

"Intravenous Stem Cell Therapy for Age-Related Cognitive Decline" (2019)

Findings: MSC infusions improve memory, reduce neuroinflammation, and enhance cognitive performance in clinical trials. Source: Journal of Neuroinflammation

Study:

"Intravenous infusion of mesenchymal stem cells improves cognitive function and reduces amyloid-beta deposition in a transgenic mouse model of Alzheimer's disease." Findings: MSCs improve cognitive function and reduce pathological features of Alzheimer's disease. Source: Frontiers

Hearing Loss

Study:

Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes."

Findings: MSCs repair cochlear cells, improving auditory function after damage or degeneration. Source: The American Journal of Pathology

Cataracts & AMD

Study:

"Mesenchymal stem cells promote the retinal ganglion cell survival and axon regeneration after optic nerve injury."

Findings: MSCs help protect and regenerate retinal cells, showing promise for AMD and cataracts. Source: PubMed

Hair Loss

Study:

"Stem Cells and Hair Follicle Regeneration" (2018)

o Findings: ADSCs regenerate hair follicles and promote new hair growth in androgenetic alopecia patients. o Source: Stem Cells and Development

Study:

"Autologous Stem Cell Therapy for Hair Regrowth" (2019)

o Findings: Autologous stem cell injections result in significant hair regrowth, promoting follicle regeneration and improved hair density. o Source: International Journal of Trichology

Study:

"Human adipose-derived stem cells improve hair density and thickness in patients with androgenetic alopecia."

o Findings: MSCs promote hair follicle regeneration, improving hair growth and thickness. o Source: PubMed

Heart Disease

Study:

"Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors"

Study:

"Stem cell therapy for heart failure in the clinics: new perspectives in the era of precision medicine and artificial intelligence" (2024)

Findings: SC therapy, combined with precision medicine and AI, improves treatment outcomes for heart failure. Source: PubMed

Study:

"Intracoronary infusion of mesenchymal stem cells and effects on left ventricular function in patients with chronic heart failure."

Findings: MSCs improve cardiac function and reduce scarring in chronic heart failure. Source: AHA Journals

Musculoskeletal Issues

Study:

"Mesenchymal stem cell therapy in musculoskeletal disorders: a review."

Findings: MSCs promote tissue repair and reduce inflammation in musculoskeletal conditions. Source: PubMed

Chronic Pain

Study:

"Biologic Therapy in Chronic Pain Management " (2021)

Findings: MSCs reduce chronic musculoskeletal pain by modulating immune response and inflammation, improving mobility. Source: Pain Medicine Journal

Study:

"Stem Cell Therapy for Chronic Pain Management: Review" (2017)

Findings: SC therapy offers hope for chronic pain relief by regenerating tissue and reducing inflammation. Source: Journal of Pain Research

Study:

"Mesenchymal stem cell transplantation modulates pain behavior in a rat model of neuropathic pain."

o Findings: MSCs alleviate chronic pain by modulating inflammatory responses and promoting tissue repair. Source: Frontiers

Arthritis

Study:

"Stem Cell Therapy in Osteoarthritis: A Meta-Analysis" (2019)

Findings: MSC therapy reduces inflammation, promotes cartilage regeneration, and improves joint function in osteoarthritis patients. Source: Stem Cells Translational Medicine

Study:

The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment" (2022)

Findings: The study shows that mesenchymal stem cells (MSCs) and their exosomes promote tissue repair, reduce inflammation, and aid bone and cartilage regeneration in orthopedic conditions like osteoarthritis and osteoporosis. Source: Arthritis Research & Therapy

Study:

"Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis: a systematic review of clinical outcomes." Findings: MSCs reduce pain, improve joint function, and enhance cartilage repair in osteoarthritis. Source: PubMed

Musculoskeletal Issues

Study:

"Stem Cell-Based Therapies for Tendon Repair"

Findings: ADSCs accelerate tendon healing, enhance strength, and prevent re-injury in athletes. Source: Stem Cell-Based Therapies for Tendon Repair

Study:

"Role of tendon-derived stem cells in tendon and ligament repair: focus on tissue engineer" (2024)

Findings: Tendon-derived stem cells (TDSCs) aid in tendon and ligament repair by differentiating into necessary cell types. Source: Frontiers

Study:

"Mesenchymal stem cell therapy for tendon repair: a systematic review."

Findings: MSCs enhance healing and functional recovery in tendon and ligament injuries.

Source: PubMed

Joint Issues

Study:

"Mesenchymal stem cells in osteoarthritis therapy: a review"

Findings: MSCs help repair damaged cartilage and reduce inflammation in joints. They support cartilage regeneration and may improve joint function.

Source: PubMed

Study:

"Strategies for Articular Cartilage Repair and Regeneration"

Findings: MSCs can repair cartilage by differentiating into chondrocytes when exposed to mechanical and hypoxic conditions. Source: Frontiers

Study:

"Mesenchymal stem cell therapy for joint diseases: a review of clinical applications."

Findings: MSCs reduce joint pain and improve cartilage regeneration in degenerative joint disorders. Source: Journal of Bone and Joint Surgery

Spinal Disc Degeneration

Study:

"Stem Cell Therapy for Degenerative Disc Disease" (2017)

Findings: MSC injections increase disc height, regenerate disc tissue, and reduce pain in degenerative disc disease patients. Source: PubMed

Study:

"Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration" (2018)

Findings: MSC therapy slows disc degeneration and restores disc integrity in preclinical and ongoing clinical trials. Source: Wiley Online Library

Study:

"Mesenchymal stem cell transplantation in intervertebral disc degeneration: a systematic review" (2022)

Findings: MSCs repair intervertebral discs, reducing pain and improving spinal mobility. Source: Wiley Online Library

Sports Injuries

Study:

"MSC-Based Treatment of Sports-Related Cartilage Injuries" (2016)

Findings: MSC therapy improves cartilage repair, reduces pain, and enhances recovery time in athletes with cartilage injuries.

Source: British Journal of Sports Medicine

Study:

"Emerging Applications of Stem Cell and Regenerative Medicine to Sports Injuries” (2014)

Findings: MSC can accelerate recovery by promoting tissue regeneration, reducing inflammation, and healing tendons, ligaments, and cartilage.

Source: PubMed

Study:

"Mesenchymal Stem Cells for Treatment of Tendon and Ligament Injuries-clinical Evidence" (2020)

Findings: SMSCs accelerate recovery from ligament, tendon, and muscle injuries, enhancing tissue repair. Source: PubMed

Obesity

Study:

"Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment" (2023)

Findings: ADSCs show promise in treating obesity and related metabolic disorders by improving metabolism, reducing inflammation, and regenerating fat tissue. Source: MDPI

Study:

"Adipose-Derived Stem Cells, Obesity, and Inflammation" (2022)

Findings: T(ADSCs) help reduce obesity-related inflammation and aid in osteoarthritis treatment by promoting tissue repair and cartilage regeneration. Source: PubMed

Study:

"Stem Cell Therapy for Obesity and Metabolic Syndrome" (2016)

Findings: MSC can potentially treat metabolic syndrome by reducing inflammation, regulating fat cell formation, and improving insulin resistance. Source: Wiley Online Library

Study:

"Adipose-derived mesenchymal stem cells improve insulin sensitivity in obesity."

Findings: MSCs reduce inflammation and improve metabolic function in obese individuals. Source: JCEM

Reproductive & Sexual Wellness

Study:

"Mesenchymal stem cells in reproductive medicine: current applications and future directions."

Findings: MSCs improve ovarian function, sperm quality, and hormonal balance, enhancing reproductive health. Source: Oxford Academic

Erectile Dysfunction

Study:

"Potential of Adipose ‐ Derived Stem Cells for Treatment of Erectile Dysfunction" (2009)

Findings: ADSCs improve erectile function by regenerating blood vessels and increasing penile blood flow. Source: The Journal Of Sexual Medicine

Study:

"Mesenchymal Stem Cell Therapy for Erectile Dysfunction Due to Diabetes" (2017)

Findings: MSC therapy regenerates nerves and blood vessels, improving erectile function in diabetic patients with ED. Source: Stem Cells Translational Medicine

Study:

"Intracavernous injection of MSCs improves erectile function in a diabetic rat model."

Findings: MSCs repair vascular damage, improving erectile function and blood flow. Source: The Journal Of Sexual Medicine

Libido Decline

Study:

"Enhancing Sexual Health with Stem Cell Therapy: Results from the ACESO & CERES Trials in Diabetes and Metabolic Syndrome" (2022)

Findings: MSC infusion therapy improved sexual function, libido, and hormonal balance in both men and women with metabolic issues. Source: The Journal Of Sexual Medicine

Study:

"Hormonal Regulation and Stem Cell Therapy for Libido Decline" (2022)

Findings: TMSCs positively influence testosterone and estrogen levels, enhancing sexual desire and performance. Source: Frontiers

Study:

"Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction.

Findings: MSCs may improve sexual function in aging individuals by restoring hormonal balance and enhancing reproductive health. Source: Frontiers

Endometriosis

Study:

"Mesenchymal stem cells reduce inflammation and improve tissue remodeling in endometriosis."

o Findings: MSCs suppress inflammation and alleviate symptoms of endometriosis. o Source: Journal of Biological Engineering

Chronic Venous Insufficiency & Varicose Veins

Study:

"Stem cell therapy for vascular disorders: potential applications in venous insufficiency."

o Findings: MSCs enhance vascular repair, reducing symptoms of venous insufficiency. o Source: ScienseDirect

Peripheral Neuropathy

Study:

"Mesenchymal stem cells improve nerve function in diabetic peripheral neuropathy."

o Findings: MSCs promote nerve repair and alleviate neuropathic pain. o Source: ScienseDirect

Balance Disorders & Fall Prevention

Study:

"MSC therapy for vestibular dysfunction: potential to improve balance."

o Findings: MSCs restore vestibular function and reduce fall risk in balance disorders. o Source: Cell Report

Hypothyroidism

Study:

"MSC transplantation for hypothyroidism: preclinical evidence."

o Findings: MSCs reduce autoimmune attacks on thyroid tissue, improving thyroid function and restoring hormonal balance. o Source: PubMed

Study:

"Stem Cells for Regulating Thyroid Function in Autoimmune Hypothyroidism."

o Findings: MSCs modulate the immune response in autoimmune thyroiditis, promoting thyroid tissue repair.

o Source: PubMed

Hyperthyroidism

Study:

"Insight Into Mouse Models of Hyperthyroidism."

o Findings: MSCs reduce thyroid overactivity, modulate immune function, and alleviate hyperthyroid symptoms. o Source: Frontiers

Cushing's Syndrome

Study:

"MSC-based treatments in endocrine disorders: potential applications in Cushing's syndrome."

o Findings: MSCs regulate hormonal imbalances, reduce systemic inflammation, and alleviate symptoms of Cushing's syndrome. o Source: Journal of Clinical Endocrinology & Metabolism

Addison's Disease

Study:

"MSC transplantation for adrenal insufficiency in Addison's disease: mechanisms and outcomes."

Findings: MSCs improve adrenal function, modulate immune responses, and restore hormonal balance in Addison's disease. Link: PubMed

Hyperparathyroidism

Study:

"Hypoparathyroidism: State of the Art on Cell and Tissue Therapies."

o Findings: MSCs regulate parathyroid hormone levels, reduce bone loss, and promote bone repair in hyperparathyroidism. o Source: PubMed

Study:

"MSC transplantation for hypoparathyroidism: preclinical and clinical evidence."

o Findings: MSCs promote calcium balance, improve parathyroid function, and alleviate symptoms in hypoparathyroidism. o Source: Frontiers

Study:

"Mesenchymal stem cells for hypoparathyroidism: a novel treatment strategy."

o Findings: MSCs restore calcium homeostasis and support parathyroid gland repair. o Source: MDPI

Eczema

Study:

"Therapeutic Potential and Mechanisms of MSCs and Their Extracellular Vesicles in Atopic Dermatitis." (2024)

Findings: MSCs and their extracellular vesicles show promise in treating atopic dermatitis by reducing inflammation and modulating immune responses. Source: Journal of Inflammation Research

Chronic Sinusitis

Study:

"MSC therapy for chronic rhinosinusitis: inflammation modulation and tissue repair."

Findings: MSCs reduce sinus inflammation, promote tissue regeneration, and alleviate chronic symptoms. Source: Stem Cell Research & Therapy

Sarcoidosis

Study:

"Cellular Therapy Could Soothe Sarcoidosis"

Findings: MSCs may modulate immune responses and reduce inflammation in sarcoidosis, offering a potential therapeutic approach. Source: NIH Intramural Research Program

Polycystic Ovary Syndrome (PCOS)

Study:

"MSC therapy for polycystic ovary syndrome: emerging evidence."

o Findings: MSCs improve ovarian function, regulate hormones, and reduce inflammation in PCOS patients. o Source: MDPI

Epilepsy

Study:

"The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives.”

o Findings: MSCs protect neurons, reduce seizure frequency, and modulate neuroinflammation in epilepsy. o Source: Journal of Translational Medicine

Hypoxic-Ischemic Encephalopathy

Study:

"MSC therapy for neonatal hypoxic-ischemic encephalopathy: outcomes and mechanisms."

Findings: MSCs reduce neuronal damage, promote repair, and improve utcomes in HIE. Source: PubMed

Heavy Metals

Study:

"Challenges of mesenchymal stem cells in the clinical treatment of COVID-19"

o Findings: The study discusses MSCs' potential in reducing oxidative stress and promoting tissue repair, which may be applicable to heavy metal toxicity. o Source: Cell and Tissue Research

Radiation

Study:

" The Main Mechanisms of Mesenchymal Stem Cell-Based Therapy in Treating COVID-19"

o Findings: MSCs' regenerative properties and ability to mitigate inflammation suggest potential in treating radiation-induced injuries o Source: Cellular and Molecular Bioengineering

Drug-Related

Study:

"MSC therapy in toxicology: therapeutic effects in radiation and heavy metal exposure."

o Findings: MSCs reduce oxidative stress, detoxify tissues, and repair damage from radiation or heavy metals. o Source: PubMed

COPD (Chronic Obstructive Pulmonary Disease)

Study:

"Intravenous MSCs improve lung function in patients with COPD: a pilot trial."

Findings: MSCs reduce inflammation and improve respiratory function and quality of life in COPD patients. Source: Stem Cell Research & Therapy

Long-COVID

Study:

"Mesenchymal stem cells for post-COVID lung syndrome: clinical evidence."

Findings: MSCs repair lung tissue and reduce inflammation in patients with Long-COVID. Source: Journal of Translational Medicine

Asthma

Study:

"MSC-based therapy reduces airway inflammation in allergic asthma."

Findings: MSCs improve airway function and reduce inflammation in asthma patients. Source: Stem Cell Research & Therapy

Kidney Disease

Study:

"MSC therapy for chronic kidney disease: mechanisms of repair."

Findings: MSCs enhance renal function, reduce fibrosis, and modulate immune responses in chronic kidney disease. Source: Stem Cell Research & Therapy

Fatty Liver

Study:

"MSC transplantation reduces hepatic inflammation in non-alcoholic fatty liver disease."

Findings: MSCs repair liver tissue, reduce fat deposition, and improve liver function. Source: Stem Cell Research & Therapy

Cirrhosis

Study:

"MSC therapy for liver cirrhosis: clinical outcomes."

Findings: MSCs promote liver regeneration, reduce fibrosis, and improve hepatic function in cirrhosis patients. Source: Frontiers in Cell and Developmental Biology

Diabetic Foot

Study:

"Mesenchymal stem cell therapy for diabetic foot ulcers: a meta-analysis."

Findings: MSCs accelerate wound healing, improve vascularization, and reduce complications in diabetic foot ulcers. Source: PubMed

Wound Healing

Study:

"MSC therapy for chronic wounds: clinical and preclinical evidence."

Findings: MSCs enhance tissue regeneration and improve healing rates in chronic wounds. Source: Stem Cell Research & Therapy

Alzheimer's Disease

Study:

"Mesenchymal stem cells reduce amyloid-beta and improve cognitive function in Alzheimer's models."

Findings: MSCs reduce amyloid plaques, protect neurons, and improve cognitive function. Source: Stem Cell Research & Therapy

Parkinson's Disease

Study:

"MSCs improve dopaminergic neuron survival and motor function in Parkinson's models."

o Findings: MSCs reduce inflammation, enhance neuronal survival, and improve motor symptoms in Parkinson's disease. o Source: PubMed

Multiple Sclerosis (MS)

Study:

"Mesenchymal Stem Cell Therapy in Multiple Sclerosis: A Systematic Review and Meta-Analysis"

o Findings: MSC therapy for MS improved motor and sensory functions, helping reduce disability and slow disease progression. o Source: MDPI

Stroke Recovery

Study:

"Mesenchymal stem cell therapy in ischemic stroke: neuroprotective and regenerative effects."

Findings: MSCs reduce inflammation, promote neurogenesis, and improve functional recovery after a stroke. Link: Stem Cell Research & Therapy

ALS (Amyotrophic Lateral Sclerosis)

Study:

"MSC transplantation slows ALS progression and improves motor neuron survival."

o Findings: MSCs reduce neuroinflammation and oxidative stress, slowing disease progression and improving functional outcomes in ALS patients. o Source: ALS News Today

Spinal Cord Injuries

Study:

"MSC therapy promotes axonal regeneration and functional recovery in spinal cord injuries."

o Findings: MSCs support tissue repair, reduce scarring, and improve motor function in spinal cord injuries. o Source: PubMed

Crohn's Disease

Study:

"MSC therapy for perianal fistulas in Crohn's disease: clinical applications."

o Findings: MSCs promote fistula closure, reduce inflammation, and improve intestinal healing in Crohn's disease. o Source: Stem Cell Research & Therapy

Ulcerative Colitis

Study:

"Mesenchymal stem cells reduce inflammation and promote mucosal healing in ulcerative colitis."

Findings: MSCs improve mucosal integrity, reduce disease activity, and promote tissue regeneration in ulcerative colitis patients. Source: Stem Cell Research & Therapy

Rheumatoid Arthritis (RA)

Study:

"MSC transplantation reduces joint inflammation and preserves cartilage in rheumatoid arthritis."

Findings: MSCs reduce inflammation, promote cartilage repair, and improve joint mobility in rheumatoid arthritis. Source: Stem Cell Research & Therapy

Lupus (SLE)

Study:

"MSC-based therapies for systemic lupus erythematosus:"

Findings: MSCs suppress immune overactivity, reduce disease severity, and improve organ function in lupus patients. Source: Stem Cell Research & Therapy

01 40

Psoriasis

Study:

"MSC therapy reduces inflammation and improves skin lesions in psoriasis."

Findings: MSCs enhance skin repair, reduce psoriatic plaques, and improve quality of life for patients with psoriasis. Source: Stem Cell Research & Therapy

HBOT Research Studies

Hyperbaric Oxygen Therapy (HBOT)

Study:

"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial." Findings: HBOT increased telomere length and reduced senescent cells in healthy aging adults, highlighting its potential anti-aging benefits Source: Aging-US

Study:

"Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients—a retrospective analysis."

Findings: HBOT improved cognitive functions such as memory and attention in post-stroke patients, aiding neurological recovery. Source: Restorative Neurology and Neuroscience

Study:

"Hyperbaric oxygen therapy can diminish fibromyalgia syndrome—prospective clinical trial."

Findings: HBOT significantly reduced pain and enhanced quality of life for fibromyalgia patients. Source: PLOS ONE

Study:

"Hyperbaric oxygen therapy for traumatic brain injury: a systematic review of the literature.""

Findings: HBOT improved outcomes in patients with traumatic brain injury, including reduced mortality and better neurological recovery. Source: Medical Gas Research

Study:

"Hyperbaric oxygen therapy for radiation-induced late side effects in normal tissues."

Findings: HBOT promoted healing in tissues damaged by late radiation side effects, improving quality of life. Source: Wiley Online Library

Study:

"Hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a systematic review."

Findings: HBOT improved healing rates in diabetic foot ulcers, reducing the risk of major amputations. Source: Diabetes Care

Study:

"Hyperbaric oxygen therapy for the treatment of long COVID: early evaluation of a highly promising intervention."

Findings: HBOT alleviated long COVID symptoms, such as fatigue and cognitive impairments, in preliminary studies. Source: Frontiers in Medicine

Study:

"Hyperbaric oxygen therapy for the treatment of post-traumatic stress disorder associated with traumatic brain injury." Findings: HBOT reduced symptoms of PTSD, including anxiety and depression, in affected individuals. Source: DovePress

Study:

"Hyperbaric oxygen therapy in the management of chronic wounds: a systematic review."

Findings: HBOT enhanced healing in chronic wounds, such as pressure ulcers and venous leg ulcers. Source: International Wound Journal

Study:

"Hyperbaric oxygen therapy in sports injuries: enhancing recovery and performance."

Findings: HBOT accelerated recovery from sports-related injuries by reducing inflammation, promoting tissue repair, and improving oxygenation in damaged tissues. Source: SagePub

Study:

"Hyperbaric Oxygen Therapy for Acute Ischemic Stroke."

Findings: HBOT improved neurological outcomes and reduced mortality in ischemic stroke patients. Source: Stroke

Molecular Hydrogen Inhalation Studies

Study:

"Molecular Hydrogen Therapy—A Review on Clinical Studies and Future Perspectives"

Findings: This review highlights the antioxidant properties of hydrogen gas and its therapeutic effects in conditions such as cardiovascular diseases, cancer, respiratory diseases, neurological disorders, and infections. It also discusses challenges in hydrogen administration and potential future technologies. Source: MDPI

Study:

"Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders"

Findings: The study explores hydrogen gas inhalation as a therapeutic method for brain disorders. It emphasizes the safety and practicality of hydrogen inhalation and hydrogen-rich water for both treatment and prevention. Source: Springer

Study:

"Case Report on a Novel Application of Molecular Hydrogen Inhalation Therapy for Parkinson's Disease and Persistent Post-Concussive Syndrome" Findings: This case report demonstrates significant neurological improvements in a patient with Parkinson's disease and post-concussive syndrome following hydrogen gas inhalation therapy. The study suggests hydrogen's potential in reducing inflammation, oxidative stress, and improving vascular function. Source: Hue Light USA

Study:

"Molecular Hydrogen: From Molecular Effects to Stem Cells Applications"

Findings: This review examines hydrogen gas administration through various methods (inhalation, water, saline) and highlights its antioxidant properties and potential applications in stem cell-based therapies and disease treatments. Source: MDPI

Study:

"Hydrogen - An Emerging Medical Gas"

Findings: This article reviews hydrogen's role as a medical gas, focusing on its unique antioxidant capabilities and applications in conditions such as inflammation, neurodegeneration, and metabolic syndromes. Source: Molecular Hydrogen Institute

Photobiomodulation (PBM) Light Studies

Study:

"Photobiomodulation—Underlying Mechanism and Clinical Applications"

Findings: This review outlines the mechanisms of PBM, including its effects on mitochondrial function and cellular signaling, and explores its applications in medicine and dentistry. Source: PMC

Study:

"Red Light Therapy: Effectiveness, Treatment, and Risks"

Findings: Highlights the effectiveness of red light therapy for treating acne, wrinkles, and pain while discussing its benefits and potential risks. Source: WebMD

Study:

"Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review"

Findings: Explores the combined use of PBM with other therapies for neurological and neuropsychiatric disorders, demonstrating enhanced outcomes. Source: BMC Neurology

Study:

"Advances in photobiomodulation for cognitive improvement by near-infrared light"

Findings: Examines the use of near-infrared light PBM to improve cognitive functions, suggesting potential for neurorehabilitation. Source: Translational Medicine

Study:

"Photobiomodulation efficacy in age-related macular degeneration: a systematic review and meta-analysis"

Findings: Demonstrates PBM's effectiveness in managing dry age-related macular degeneration, showing potential to halt or reverse disease progression. Source: Journal of Retina & Vitreous

Study:

"Photobiomodulation: The Clinical Applications of Low-Level Light Therapy"

Findings: Reviews PBM's applications in aesthetic medicine, including skin rejuvenation and treatment of various skin conditions. Source: Aesthetic Surgery Journal

Study:

"Improvements in clinical signs and symptoms of Parkinson's disease following photobiomodulation: a long-term study"

Findings: Reports significant improvements in both motor and non-motor symptoms in Parkinson's disease patients following long-term PBM therapy. Source: BMC Neurology

Study:

"Mechanisms and applications of the anti-inflammatory effects of photobiomodulation"

Findings: Explores PBM's anti-inflammatory mechanisms and its applications in treating inflammatory conditions across various systems. Source: AIMS Biophysics

Study:

"Transcranial low-level laser stimulation in near infrared-II region for brain safety and protection"

Findings: Investigates the neuroprotective effects and safety of transcranial PBM using near-infrared light, suggesting benefits for brain health. Source: arXiv

Study:

"Activating Brain-Gut Connection with Light Reduces Depression"

Findings: Explores how PBM targeting the brain-gut axis can alleviate symptoms of depression, highlighting its potential in mental health. Source: Neuroscience News

Micro-Impact Plate (LLMS)

Study:

"Juvent's Micro-Impact Platform for Increasing Bone Mineral Density in Pediatric Cancer Survivors"

Findings: This randomized, placebo-controlled clinical study demonstrated that Micro-Impact Therapy effectively improved total body and tibial bone mineral density (BMD) in pediatric cancer survivors. Participants who completed 70% or more of the prescribed sessions experienced a mean increase of 11.2% in tibial trabecular BMD. Source: Juvent Health Research

Study:

"Human Health Benefits of Low Magnitude Mechanical Stimulation (LMMS)"

Findings: This review discusses the anabolic effects of LMMS on the skeletal system, highlighting its role in stimulating mesenchymal stem cells toward osteoblastogenesis. Clinical studies have shown that LMMS improves pain, balance, gait quality, and inflammatory markers in elderly subjects with knee osteoarthritis. Source: Juvent Health Research

Study:

"Differentiating Human Health Benefits: Micro-Impact Therapy vs. Whole Body Vibration"

Findings: This paper compares Micro-Impact Therapy with Whole Body Vibration, emphasizing the safety and efficacy of low-magnitude mechanical stimulation in promoting bone health and reducing the risk of low back pain associated with high-magnitude vibrations. Source: Juvent Health Research

Study:

"Effect of Low-Intensity Vibration on Bone Strength"

Findings: TThis prospective, randomized, double-blinded, 12-month study evaluated the impact of low-intensity vibration on bone strength, indicating potential benefits in enhancing bone density and structural integrity. Source: Center for Skeletal Research

Study:

"Clinical Trial Confirms New Device Improves Bone Density in Cancer Survivors"

Findings: A clinical trial confirmed that the use of a Micro-Impact Platform significantly improved bone density in cancer survivors, offering a non-invasive intervention to address bone loss associated with cancer treatments. Source: GlobeNewswire

Vagal Nerve Stimulation Studies

Study:

"Vagus Nerve Stimulation Relieves Severe Depression"

o Findings: A national clinical trial led by Washington University School of Medicine in St. Louis found that vagus nerve stimulation (VNS) significantly improved depressive symptoms, quality of life, and daily functioning in patients with severe, treatment-resistant depression. o Source: Washington University School of Medicine News

Study:

“Chronic Insomnia”

o Findings: A recent trial demonstrated that transcutaneous auricular VNS is safe and effective for treating chronic insomnia, offering a potential non-pharmacological treatment option. o Source: Medscape

Study:

Inflammatory Bowel Disease (IBD)

o Findings: Emerging research suggests that VNS may help reduce inflammation and alleviate symptoms in patients with IBD, such as ulcerative colitis, by modulating the brain-gut axis. o Source: Time

Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44 Page 45 Page 46 Page 47 Page 48 Page 49 Page 50 Page 51 Page 52 Page 53 Page 54 Page 55

www.longevity-institute.com

Made with FlippingBook Annual report maker