Making a difference 2020-2021


of Melbourne, Flinders University, SAHMRI and the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP). This project has also been awarded an NHMRC Ideas Grant to prototype and validate the smart dressing in preparation for human trials. ‘BY EMBEDDING NANODIAMONDS INTO SILK FIBRES USING AN ELECTROSPINNING PROCESS, WE’VE BEEN ABLE TO DEVELOP A NATURALLY-DERIVED WOUND DRESSING THAT CAN SENSE INFECTIONS,’ SAYS DR ASMA KHALID.

ARC-supported scientists have developed a next generationwound dressing that can detect infection and improve healing in burns, skin grafts and chronic wounds. In research led by RMIT University’s Research Fellow Dr Asma Khalid, smart wound dressings made of silk and nanodiamonds could detect early signs of infection, by sensingwound temperature, as well as acting to reduce infection from certain bacteria. The team turned to diamonds – which are known to detect biologically-relevant temperatures to a highly precise level – to incorporate the heat sensing capability in the dressings. ‘The heat sensing capability opens the possibility of contactless wound monitoring. Clinicians would be able to obtain information on the wound’s status from the nanodiamond temperature readout,’ says Dr Khalid. Senior researcher, previous ARC Future FellowProfessor Brant Gibson, says it offered a solution to the global challenge of wound care and healing. ‘Traditional wound management presents a significant challenge for clinicians, who have to regularly check for infection by looking for signs of redness, heat and swelling,’ he said. ‘This newtechnologywould aid clinicians to detect infections earlier and non-invasivelywithout the painful procedure of dressing removal.’ The researchers also tested the technology for resistance to bacteria, the major cause of skinwound infections. The study found that the nanodiamond silkmembranes showed an extremely high antibacterial resistance. The research consortium included scientists fromRMIT University, The University of Adelaide and The University

Diamond silk fibres are electrospun to form porous membranes, shown in bluish green colour, with the golden-brown colour representing the skin cell growth on the membrane. Credit: Colourised by Daniel Oldfield.



Made with FlippingBook Converter PDF to HTML5