QUARTERLY BEAT / OCTOBER 2025
Limited studies have shown mild to moderate efficacy to support use of Redonyl® and Cerenia®. Redonyl® and now Dermaquin® Skin Support Supplement contain palmitoylethanolamide (PEA), an anti-inflammatory endocannabinoid supplement that reduces mast cell degranulation. PEA has been shown to reduce pruritus and lesions in atopic dogs. In a small study, Redonyl® was able to maintain methylprednisolone-reduced level of pruritus and lesions than placebo. Maropitant (Cerenia®) reduced pruritus in 11/12 cats by more than 50% and 10/12 cats had reduction in lesions on the skin in one open study conducted over 4 weeks. Topical therapy is important in cats to reduce allergen exposure and restore the barrier function of the skin. Key is to find the product that works best for the pet parent and is well-tolerated for the cat. Medicated wipes or mousse are useful to treat inflamed or focally infected areas, though some cats will tolerate bathing. I utilize low-potency steroids and tacrolimus for focally inflamed and pruritic lesions along with topical spot on products that contain essential oils and fatty acids like (Dermoscent® Essential 6 Spot-on, Atopivet® spot-on, mousse, or collar).
REFERENCES
1. Miller WH, Griffin CE, Campbell, KL. Hypersensitivity Disorders. In: Muller and Kirk’s Small Animal Dermatology , 7th Edn, St. Louis: Eslevier, 2013:388-392, 402-405. 2. Ravens, PA, Xu BJ, Vogelnest LJ. Feline atopic dermatitis: a retrospective study of 45 cases (2001-2012). Vet Dermatol . 2014;25(2):95-102. 3. Diesel A. Cutaneous hypersensitivity dermatoses in the feline patient: a review of allergic skin disease in cats. Vet Sci. 2017;4(2):25. 4. Marsella R, De Benedetto A. Atopic dermatitis in animals and people: an update and comparative review. Vet Sci. 2017;4(3):37. 5. Noli C, Matricoti I, SchievanoC. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Vet Dermatol. 2019;30(2):110-e30. 6. Santoro D, Pucheu-Haston CM, Prost C, et al. Clinical signs and diagnosis of feline atopic syndrome: detailed guidelines for a correct diagnosis. Vet Dermatol. 2021;32(1):26-40. 7. Halliwell R, Pucheu-Haston CM, Olivry T, Prost C, et al. Feline allergic diseases: introduction and proposed nomenclature. Vet Dermatol. 2021;32:8-12. 8. Mueller RS, Nuttall T, Prost C, et al. Treatment of the feline atopic syndrome- a systematic review. Vet Dermatol. 2021;32:43-60. 9. Maina E, Fontaine J. Use of maropitant for the control of pruritus in non-flea, non-food-induced feline hypersensitivity dermatitis: an open-label, uncontrolled pilot study. J Feline Med Surg . 2019;21(10):967–972. 10. Scarampella F, Abramo F, Noli C. Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study. Vet Dermatol . 2001;12:29–39.
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