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International Journal of Dentistry
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Sterify Gel + SRP SRP only
Sterify Gel + SRP SRP only
ð a Þ ð b Þ F IGURE 2: (a) Bleeding index expressed in the frequency of bleeding sites before treatment, at 1, 2, and 3 months ( n = 34). (b) Change in plaque index at 1, 2, and 3 months vs. pretreatment conditions ( n = 34). Error bars show SEM.
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observed in clinical attachment level (CAL) (Figure 1(c)), with the treatment group exhibiting superior progress com- pared to the control group. Full data on PD, gingival reces- sion, and CAL are available in Table S1. All group differences in PD, gingival recession, and CAL resulted signi fi cant ( p < 0 : 05) when tested with ANOVA. Multiple Wilcoxon tests showed signi fi cant differences in all parameters and follow-ups ( p < 0 : 05), with the exception of gingival recess at 1 month ( p > 0 : 05). 3.2. Comparison of Bleeding and Plaque Index Scores, Pain Perception, and Adverse Events during Treatment between Sterify Gel and SRP Alone. Nosigni fi cant differences were found in the bleeding (Figure 2(a)) and plaque index (Figure 2(b)) scores between the two groups ( p > 0 : 05). Notably, the bleeding index ameliorated in both groups compared to pretreatment conditions. Similarly, pain perception during the treatment procedure was generally not reported or indicated as absent in most cases (data not shown), resulting in no signi fi cant dis- tinction between the Sterify Gel and control groups. More- over, no adverse events were reported in this study. Full data on plaque index are available in Table S1, and data on bleed- ing index are available in Table S2. 3.3. In fl uence of Sterify Gel on Tooth Mobility and Furcations. No signi fi cant disparities were observed in tooth mobility (Figure 3) or furcation (data not shown) reduction between the two groups ( p > 0 : 05). Only a minor, although not sig- ni fi cant, tendency for better tooth stability was seen at 2 and 3 months in the treatment group compared to the control group. Full data on tooth mobility are available in Table S1. 3.4. Reduction of Bacterial Contamination in Periodontal Pockets following Treatment with Sterify Gel. The frequency of bacterial contamination was comparable between the
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Sterify Gel + SRP SRP only
F IGURE 3: Tooth stability, i.e., change in the degree of mobility com- pared to before treatment conditions, at 1, 2, and 3 months ( n = 34). Error bars show SEM.
treatment and control groups at baseline conditions, except for the Prevotella intermedia bacterial strain. At 3 months follow-up, a “ negative shift ” toward less bacterial positivity was observed in the treatment group, indicating a statistically signi fi cant trend ( p < 0 : 05) toward reduced bacterial contami- nation (Figure 4(a)). This trend was not observed in the control group who received SRP only (Figure 4(b)), where no statisti- cally signi fi cant differences were found ( p > 0 : 05). Full data on bacterial contamination is available in Table S3. 4. Discussion Our study represents the fi rst clinical investigation of Sterify Gel, an innovative polyvinyl hydrogel, for the treatment of chronic periodontitis. The absence of reported adverse events during the use of Sterify Gel in the study underscores
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