Evaluation of Sterify Gel as an Adjunctive Treatment to Sca…

International Journal of Dentistry

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Acknowledgments This research was funded by the manufacturer Sterify S.r.l. The authors wish to thank Omar Sabry (Sciently) for his support in the draft of the manuscript. Supplementary Materials The supplementary material accompanying this manuscript comprises additional tables containing a comprehensive compilation of clinical parameters obtained during the clini- cal trial, including change vs. pretreatment conditions in pocket depth, gingival recess, clinical attachment level, pla- que index, degree of mobility. Supplementary tables also describe bleeding index and bacterial contamination in details. Table S1: clinical outcomes measurement between the study groups compared with pretreatment conditions. Table S2: frequency of bleeding sites between the study groups. Table S3: number of observations and frequency of bacterial contami- nation (all bacteria strains). ( Supplementary Materials )

[13] G. S. Grif fi ths, G. J. Smart, J. S. Bulman, G. Weiss, J. Shrowder, and H. N. Newman, “ Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronida- zole gel, ” Journal of Clinical Periodontology , vol. 27, no. 12, pp. 910 – 917, 2000. [14] M. Stelzel and L. Flor è s-de-Jacoby, “ Topical metronidazole application as an adjunct to scaling and root planing, ” Journal of Clinical Periodontology , vol. 27, no. 6, pp. 447 – 452, 2000. [15] K. M. Fawzy El-Sayed, M. A. Dahaba, S. Aboul-Ela, and M. S. Darhous, “ Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial, ” Clinical Oral Investigations , vol. 16, pp. 1229 – 1236, 2012. [16] H. Zhao, J. Hu, and L. Zhao, “ Adjunctive subgingival application of chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis, ” BMC Oral Health , vol. 20, Article ID 34, 2020. [17] J. G. Fern á ndez-Bola ñ os, Ó . L ó pez, M. Á . L ó pez-Garc í a, and A. Marset, “ Biological properties of hydroxytyrosol and its derivatives, ” in OliveOil — Constituents, Quality, Health Properties and Bioconversions , B. Dimitrios, Ed., InTech, 2012. [18] M. Bertelli, A. K. Kiani, S. Paolacci et al., “ Hydroxytyrosol: a natural compound with promising pharmacological activi- ties, ” Journal of Biotechnology , vol. 309, pp. 29 – 33, 2020. [19] J. M. Shin, J. W. Gwak, P. Kamarajan, J. C. Fenno, A. H. Rickard, and Y. L. Kapila, “ Biomedical applications of nisin, ” Journal of Applied Microbiology , vol. 120, no. 6, pp. 1449 – 1465, 2016. [20] M. Fiorini, V. Crognaletti, O. Sabry, L. Scalise, and P. Fattori, “ Hydroxy-tyrosol as a free radical scavenging molecule in polymeric hydrogels subjected to gamma-ray irradiation, ” Processes , vol. 9, no. 3, pp. 433 – 10, 2021. [21] E. Oral, H. Bodugoz-Senturk, C. Macias, and O. K. Muratoglu, “ Vitamin C hinders radiation cross-linking in aqueous poly (vinyl alcohol) solutions, ” Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms , vol. 265, no. 1, pp. 92 – 97, 2007. [22] S. C. Nair and K. R. Anoop, “ Intraperiodontal pocket: an ideal route for local antimicrobial drug delivery, ” Journal of Advanced Pharmaceutical Technology & Research , vol. 3, no. 1, pp. 9 – 15, 2012. [23] M. S. Putt, M. E. Mallatt, L. L. Messmann, and H. Proskin, “ A 6-month clinical investigation of custom tray application of peroxide gel with or without doxycycline as adjuncts to scaling and root planing for treatment of periodontitis, ” American Journal of Dentistry , vol. 27, no. 5, 2014. [24] R. Sood, A. Gulri, U. Gupta, B. Jha Kukreja, and V. Dodwad, “ Ef fi cacy of biodegradable xanthan based chlorhezidine gel (Chlosite ® ) and0.2 % chlorhexidine irrigation following scaling and root planing for the treatment of chronic periodontitis, ” Journal of Indian Society of Periodontology , vol. 17, no. 4, pp. 439 – 443, 2014. [25] A. Pilloni, B. Zeza, D. Kuis et al., “ Treatment of residual periodontal pockets using a hyaluronic acid-based gel: a 12 month multicenter randomized triple-blinded clinical trial, ” Antibiotics , vol. 10, no. 8, Article ID 924, 2021. [26] D. A. C. Van Strydonck, D. E. Slot, U. Van der Velden, and F. Van der Weijden, “ Effect of a chlorhexidine mouthrinse on plaque, gingival in fl ammation and staining in gingivitis patients: a systematic review, ” Journal of Clinical Periodontol- ogy , vol. 39, no. 11, pp. 1042 – 1055, 2012.

References

[1] B. A. Niemiec, “ Periodontal disease, ” Topics in Companion Animal Medicine , vol. 23, no. 2, pp. 72 – 80, 2008. [2] S. S. Socransky and A. D. Haffajee, “ Dental bio fi lms: dif fi cult therapeutic targets, ” Periodontology 2000 , vol. 28, no. 1, pp. 12 – 55, 2002. [3] G. Dahl é n and Å . Leonhardt, “ A new checkerboard panel for testing bacterial markers in periodontal disease, ” Oral Microbiol- ogy and Immunology , vol. 21, no. 1, pp. 6 – 11, 2006. [4] M. S. Tonetti, H. Greenwell, and K. S. Kornman, “ Staging and grading of periodontitis: framework and proposal of a new classi fi cation and case de fi nition, ” Journal of Clinical Periodontol- ogy , vol. 45, no. S20, pp. S149 – S161, 2018. [5] I. Darby, “ Non-surgical management of periodontal disease, ” Australian Dental Journal , vol. 54, no. s1, pp. S86 – S95, 2009. [6] M. A. Cugini, A. D. Haffajee, C. Smith, R. L. Kent Jr., and S. S. Socransky, “ The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results, ” Journal of Clinical Periodontology , vol. 27, no. 1, pp. 30 – 36, 2000. [7] A. Etemadi, M. Hamidain, S. Parker, and N. Chiniforush, “ A review of blue light photodynamic therapy in management of periodontitis, ” Journal of Lasers in Medical Sciences , vol. 12, no. 1, Article ID e15, 2021. [8] D. Etienne, “ Locally delivered antimicrobials for the treatment of chronic periodontitis, ” Oral Diseases , vol. 9, no. s1, pp. 45 – 50, 2003. [9] A. D. Haffajee, S. S. Socransky, and J. C. Gunsolley, “ Systemic anti-infective periodontal therapy: a systematic review, ” Annals of Periodontology , vol. 8, no. 1, pp. 115 – 181, 2003. [10] T. J. Hall, V. M. Villap ú n, O. Addison et al., “ A call for action to the biomaterial community to tackle antimicrobial resistance, ” Biomaterials Science , vol. 8, pp. 4951 – 4974, 2020. [11] J. O ’ Neill, Tackling Drug-Resistant Infections Globally: Final Report and Recommendations , Government of the United Kingdom, London, 2016. [12] S. S. Oberoi, C. Dhingra, G. Sharma, and D. Sardana, “ Antibiotics in dental practice: how justi fi ed are we, ” International Dental Journal , vol. 65, no. 1, pp. 4 – 10, 2015.

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