Cleanroom Suites Presentation by Dermot McKenna, Ardmac
ARDMAC BY NUMBERS
Ardmac Ltd Reg. No: 58640
Ardmac Performance Contracting Reg. No: 01880651 Ardmac Sprl - Belgium Reg. No: 0643.936.877 Ardmac BV - Holland Reg. No: 69014280
Ardmac AG -Switzerland Reg. No: CHE402218871
Ardmac ApS - Denmark Reg. No: 38800639 Ardmac Asia Pacific PTE - Singapore Reg. No: 200105149G
Five main offices
Dublin Manchester Brussels Ardmac have successfully expanded in to 4# new European locations in last 10 years Cork Craigavon
Our Approach
Safety First
Early engagement & collaboration
DFMAApproach
International capability, capacity & compliance
Certainty – schedule & quality
Digital work processes
SAFETY STATISTICS
Safety First, and always • Foremost in our thinking • In everything we do • Wherever we impact
LTIR (Lost time injury rate)
40% Reduction in the accident frequency
0.64
0.61
0.35
0.34
0.06
rate from 2015 through to 2019
2019
2015
2018
2016
2017
AREAS OF EXPERTISE
CLEANROOMS
DESIGN & BUILD
REFURB & FIT OUT
DATA CENTRES
OFFERING
• Specialist Contractor (not a manufacturer installer)
• We source the products from multiple suppliers
• Design completion & Integration of services
• Procurement & Scheduling
• Construction management, Quality, Safety,
• Commissioning & Handover
Ardmac in Europe
✓ Active in the Mainland Europe for 20 Years
✓ Fully developed supply chain
✓ Repeat business with large life science clients
✓ 30nr EU based staff dedicated to cleanrooms
✓ International Projects team available for large projects ✓ Early engagement with consultants during design phase. ✓ Providing after service to life science clients Europe wide
Cleanroom Products
MONOBLOC SOLUTION
• Modules 1200mm wide X 60mm thick • Height single lift 6m approx. • Cable containment raceways • Demountable • Ceiling Loading 2.5kn/m2 UDL • Finishes • Polyester Powder coated steel
• PVC Coated Steel • PET Coated Steel • HPL (High Pressure Laminate)
MONOBLOC SOLUTION
DOUBLE FLUSH GLAZING
DOOR & INTERLOCKS
• Flush Integrated Traffic lights • Flush concealed magnet • Localised or central control module • Communicates with Fire alarm / security system
LIGHTS & TERMINAL HOUSINGS Lights
• Top or Bottom access LED lights • Central or local battery system • Maintenance Walk on • Options • Dali enabled • Smart WIFI enabled
Terminal Housings • Welded Aluminium or Steel • S. Steel or painted diffuser grilles • Options for • Injection ports
• Room side adjustable dampers • Insulation
Bi-Panel CLEANSHIELD Solutions
BI-PANEL SOLUTIONS BENIFITS:
▪ Fully Demountable ▪ Flexible solutions ▪ For an Agile facility
▪ Unlimited service voids ▪ Interchangeable Panels ▪ Parallel construction ▪ Easily Reconfigured ▪ Accessible Services
BI-PANEL CEILINGS
▪ Twin Cassette ceiling system giving multi directional cable management
▪
2.5kn/m² l oadings
▪
Allows for Parallel construction
▪ Advanced material ordering due to modular configuration
▪ Integrated modular lights and HVAC
▪ Interchangeable ceiling tiles & services
INTEGRATION OF SERVICES
• Utility Plates • Power outlets • LAF Unity • Access Stairs
AIR RETURN SOLUTIONS
• Safe Change Units • Grilles • R/A Scoops / Openings
FURNITURE
STAINLESS STEEL
STAINLESS STEEL
HPL – TRESPA FURNITURE
LAB FURNITURE
TRANSFER HATCHES & SHOWERS
Case Studies
PHARMACEUTICAL & BIOLOGICS
GSK Wavre Vaccines
Eli Lilly Biologics
Janssen Biologics 1
Alexion Biologics
Pfizer NSI Biologics
Ardmac were contracted by GSK to deliver the architectural fitout of their new ISO 6, 7 & 8 cleanrooms and coldrooms. As part of Ardmac’s innovation they introduced for the first time modular agile cleanroom partitions & ceilings to the GSK Wavre site. The cleanroom scope included Bi- Panel walls and modular ceilings allowing easy access for service coordination which facilitated finishes to be completed within one room whilst service installation continued within the adjoining rooms.
Ardmac were appointed through an IPD (Integrated Project Delivery) programme to design and construct ISO 7 & 8 cleanrooms for Lilly on the IE43 project, as well as associated controlled non-classified accommodation and support areas. Works included a full architectural package comprising epoxy floors, modular walls and 2.5Kn/M 2 interchangeable ceilings, automated and manual doors, lighting, air distribution terminal housings and low level return air systems.
Ardmac were appointed as the specialist cleanroom contractor and through early engagement they designed & Fitted out new cell culture and purification suite. The use of their heavy duty modular cleanroom ceiling created a construction platform facilitating dual activities to take place above and within the cleanroom at the same time, accelerated the overall construction phase allowing Janssen to get to the market ahead of schedule.
Alexion engaged Ardmac as the specialist cleanroom contractor and the use of modular interchangeable architectural products we through early engagement we designed and constructed Grade C & D cleanroom spaces. The scope of works included the install of a 2.5Kn/m 2 walk-on ceiling, modular partitions, doors, lights, terminal filter housings, floors, fixtures & fittings and the Design & Build of 6 ISO 8 cold rooms.
As an innovative cleanroom contractor Ardmac were tasked to design and construct three bio-manufacturing suites to ISO 6, 7 and 8 standards. The use of their heavy duty modular cleanroom ceiling which doubled as a construction platform allowing 1 st and 2 nd fix activities to take place above and below the ceiling simultaneously delivering one of the fastest to market facilities for Pfizer.
8,000m²
13,000m²
5,000m²
6,500m²
3,000m²
GENE & CELL THERAPY + PHARMA
CTC Catapult
Takeda
GSK Worthing
Teva Pharmaceuticals TEVA engages Ardmac as the specialist cleanroom contractor and through early engagement we designed and constructed ISO 7 and 8 pharmaceutical facility. The scope of works included the twin cassette agile ceiling allowing parallel construction above and below the ceiling simultaneously, cleanroom partitions, door, door automation and glazing, decontamination showers, interlocks and furniture.
MSD OSS
This Cell and Gene Therapy Catapult manufacturing centre was constructed to provides clients with the supported environment to develop large-scale manufacturing systems. Ardmac were appointed to design and construct an ISO 7&8 facility which consists of six identical cleanrooms and to created a flexible module design and support infrastructure which is adaptable to clients process, whether they be allogenic, viral vector or autologous.
Ardmac constructed a new high containment state of the art production facility dedicated to the manufacture of oncology product Ninlaro, a treatment for patients with multiple myeloma. The scope included Cleanroom partitions, next generation Twin Cassette ceiling, Lights, Terminal HEPA housings, furniture & accessories to create an ISO 7 & 8 facility.
GSK engages Ardmac as the specialist cleanroom contractor and through early engagement we designed and constructed ISO 5, 7 and 8 pharmaceutical facility. The scope included all architectural elements, interchangeable modular ceilings, partitions & floors to cGMP requirements, together with performance responsibility for ATEX and standard lighting, and Terminal housings,
MSD appointed Ardmac as their cleanroom contractor to extend their manufacturing facility with in a live environment. The selection and adaptation of agile cleanroom products allowed Ardmac designed and constructed their ISO7 and 8 facility. The scope included all architectural elements, Twin Cassette ceilings, partitions & floors to cGMP requirements, together with performance responsibility for lighting, Terminal housings, and decontamination misting showers.
1800m²
1,500m²
1,300m²
1,700m²
900m²
PHARMACEUTICAL & BIOLOGICS
Jazz Pharmaceuticals Ardmac were appointed by Jazz Pharma as the specialist cleanroom contractor to design and construct ISO 7 & 8 cleanroom suites for the manufacture of orphan drugs. The scope included all architectural elements, Twin Cassette modular ceilings, partitions & floors, lighting, Terminal HEPA housings, doors glazing and door automation.
Janssen Biologics 2
Allergan Dublin Abbvie
Allergan Bio 2 Westport
This project was an extension to the existing Cork facility which Ardmac had completed previously.
Allergan engaged Ardmac to construct a new Oral Solid Dosage Pilot Plant & Small Scale Manufacturing Centre at their Clonshaugh facility in Dublin.
Abbvie engaged Ardmac to convert an existing warehouse into ISO 7 and 8 cleanroom for medicines to treat thyroid and kidney-related conditions. Works included a full architectural package comprising epoxy floors, modular walls and ceilings, automated and manual doors, gowning and laboratory furniture, and lighting, air distribution and decontamination showers.
Ardmac were appointed by Allergan Pharmaceuticals as the specialist cleanroom contractor to construct their new Biologics facility for the manufacture of Botox. The new facility consisted of ISO 5, 6 & 7 suites including HPL partitions, maintenance access ceiling, gel ceiling, Fan Filter Units, hinged and sliding doors including automation, lighting and terminal housings.
The scope included design completion & construction of new cleanroom on level 1 and level 2 of the Production extension and also within the Dispensary on Level 1 of the Warehouse extension within Janssen Sciences facility. Ardmac provided walk on twin cassette ceilings, modular partitions, doors & door automation, interlocks, Terminal housings & lights, for the ISO 7&8 suites.
The work consists of internal alterations within a redundant
single storey fallow area of building 2 and included partition, ceilings, lights, terminal HEPA housings, decontamination showers and floors to create an ISO 7 & 8 facility.
1,200m²
2,500m²
700m²
1,800m²
1,300m²
Thank You Dermot McKenna (dermot.mckenna@Ardmac.com)
QUESTIONS ?
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