The Cutting-Edge Science of Slowing Aging Breaking the Grip of Time
Over the last century, vast improvements in public health have led to nearly doubling the average human lifespan. Now, researchers are targeting even greater gains to slow the aging process and prevent dementia. At Columbia University, one research team is using animal models to explore techniques to change brain activity in areas that coordinate circadian rhythms. By improving sleep, scientists believe they may be able to reduce the risk of dementia, cardiovascular disease, and cancer. Other researchers are analyzing lab data from patients’ medical records to calculate biological age and assess its value in predicting health risks and improving care planning. At Yale University, scientists are studying rodents that live long lives to determine the metabolites that may slow the aging process. Researchers are also looking at
how to slow the organ damage caused by inflammation or changes in blood supply, which are common problems in old age. New technologies such as genome sequencing and machine learning have helped spur advances in aging research. At the Buck Institute for Research on Aging near Novato, California, scientists are analyzing large data sets from fruit flies and humans to identify the central metabolites that shape the lifespan in both species. They have identified one metabolite, threonine, as a potential therapeutic for interventions in aging. Artificial intelligence and systems biology enabled these researchers to skip testing mice, which is usually essential in determining whether discoveries apply to humans. Aging research has evolved in both scope and purpose. The latest efforts bring together scientists
from many fields who have seldom collaborated. The initiatives reflect a growing awareness that disease is not necessarily part of the aging process. Rather than simply increasing people’s lifespan, scientists focus on improving the “health span,” or years lived free of disability and disease. The goal is to keep older people around longer and maximize seniors’ natural generativity — the natural human desire at later stages of life to improve the world and support younger generations. Researchers also hope to reduce the burden of disease, as people over 65 are on track to outnumber those 18 and younger within the next decade.
LEMON GARLIC BUTTER CHICKEN
Ingredients • 4 chicken thighs, bone-in, skin-on • Salt and pepper, to taste • 2 tbsp olive oil
• 1/4 cup low-sodium chicken broth • 2 tbsp heavy cream • 1 lemon, zest and juice • 2 tbsp chopped parsley, for garnish
• 2 tbsp unsalted butter • 2 cloves garlic, minced
Directions
1. Preheat oven to 400 F and season chicken with salt and pepper. 2. Heat olive oil in an oven-proof skillet over medium heat. Sear chicken skin-side down until crispy, about 5 minutes. Flip and cook 2 more minutes; remove from skillet and set aside. 3. Melt butter in skillet, then sauté garlic until fragrant. Add broth, cream, lemon juice, and zest. Simmer for 3 minutes. 4. Return chicken to skillet, spoon sauce over, and bake in oven for 15–20 minutes or until cooked through (165 F internal temperature). Garnish with parsley before serving.
480-442-9498 • 3
Inspired by DietDoctor.com
Made with FlippingBook Ebook Creator