Royal Society of Chemistry | Books | rsc.li/medicinal-books
Royal Society of Chemistry | Books | rsc.li/medicinal-books
Drug Discovery
Drug Discovery
Modern and Emerging Synthetic Technologies for Drug Discovery Ying Wang AbbVie, USA | Anil Vasudevan AbbVie, USA Synthesis is a prominent rate-limiting step in the drug discovery process and the implementation of new technologies to enhance the quality and efficiency of drug discovery is an important aspect of new developments. Emerging Synthetic Technologies for Drug Discovery is an excellent resource on the applications and future of key emerging synthetic technologies from key opinion leaders in the field. The use of high throughput experimentation, photo redox chemistry and automated and computer aided synthesis are comprehensively covered in a single volume, ideal for postgraduates and researches in drug discovery and medicinal chemistry in both industry and academia. Organic Chemistry of Drug Degradation Min Li Merck, USA 2nd Edition The vast majority of drugs are organic molecular entities. A clear understanding of the chemistry of drug degradation is essential to maintaining the stability, efficacy and safety of medicines throughout their shelf-life. This revised and updated edition examines various degradation pathways with an emphasis on the underlying chemical mechanisms. This approach is essential for degradant identification, formulation development, and manufacturing process improvement. Much of the book is devoted to relevant organic reactions which are reviewed and illustrated with examples. It finishes with a discussion of the strategies for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. This book will be a valuable resource for students and professionals in pharmaceutical and analytical sciences. Emerging Small Molecule Therapies for Immuno-oncology Angela D'Agostino Celgene, USA | Mark Hill Celgene, USA Traditional therapies for cancer treatment have been effective but frequently have adverse side effects due to their nonspecific action on both normal and tumor cells. As such, development of targeted treatment strategies using small molecules have gained momentum and small molecule therapeutics are critical to continuing recent success with biotherapeutics in immune therapy for cancer. Emerging Small Molecule Therapies for Immuno-oncology is a comprehensive review of the current small molecules and drug discovery initiatives in immuno-oncology with projections for future developments in the field. This book also provides biological context for the role of a diverse range of chemical targets in modulating the activity of different immune mechanisms in the tumor microenvironment making it an ideal resource for any postgraduates, researchers and pharmacologists working in drug discovery and development for oncology.
The Medicinal Chemist's Guide to Solving ADMET Challenges Patrick Schnider Roche, Switzerland Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.
Hardback | 400 pages 9781839161674 | 2022 £179.00 | $250.00
Hardback | 518 pages 9781788012270 | 2021 £169.00 | $235.00
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Hardback | 400 pages 9781839164484 | 2022 £179.00 | $250.00
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Hardback | 400 pages 9781788017688 | 2022 £179.00 | $250.00
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