Hyperostosis Frontalis Interna and Decreased Frontal Lobe Mass in Female Cadaver with Parkinsonism, Supranuclear Palsy, and Stroke Rhodes Van Houten*, Harmony Lee*, Ryan Galindo Project Mentor(s): Ryan Galindo, EdD Introduction: Clinical diagnosis of neurodegenerative diseases is derived from symptomatic presentation. In contrast, the gold standard for diagnosis of neurodegeneration is postmortem confirmation. Conditions such as Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) can be visually discerned in cadaveric models as atrophy of tissue in the brainstem, specifically the substantia nigra (PD) and midbrain (PSP). Methods: This case report presents visual verification of multiple neurological conditions in a 73-year-old female cadaver with clinical diagnoses of PD and PSP. Dissection followed the procedures for a complete laminectomy, in which the brain and spinal cord are removed as a unit through dissection of the paraspinous muscles and removal of laminae. Secondary dissection involved mid-sagittal sectioning of the cerebrum, brainstem, and cerebellum, as well as unilateral transverse sectioning of the brainstem at the level of the superior colliculi to examine the substantia nigra. Results: These dissections provide evidence to support the presence of PD via depigmentation of the substantia nigra, PSP via atrophy of the midbrain, and CVA via localized tissue damage in the posteromedial parietal lobe. This study also identified an undiagnosed condition of hyperostosis frontalis interna (HFI): a condition characterized by benign thickening of the frontal bone with moderate prevalence in post-menopausal females. Discussion: This report discusses the unique presentation of a cadaveric brain with related neurodegenerative diseases through visual verification of premortem clinical diagnoses, as well as providing insight into the under-researched condition of HFI. Presentation Type: Oral Presentation (May 20, 9:30am–5:00pm) Keywords: Dissection, Neurodegeneration, Case Report, Hyperostosis, Anatomy SOURCE Form ID: 8
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