PRE CLINICAL SCIENCE
ROLE OF INSULIN LIKE GROWTH FACTOR II IN MAGNETIC FIELD REGULATION IN BONE FORMATION RYABY JT, FITZSIMMONS RJ, KHIN N, CULLEY P, MAGEE F, WEINSTEIN A, BAYLINK DJ SUMMARY: The authors investigated the biological mechanism by which combined alternating current and direct current magnetic fields (CMF ™ ) help promote bone growth. The study focused on insulin-growth factors (IGF) because of the ability of IGF to stimulate osteoprogenitor cell proliferation, with DNA synthesis service as a marker for cell proliferation. The effect of CMF on IGF-II production and DNA synthesis was measured in both osteoblast-like cell cultures as well as rat fracture callus culture model after 30 minutes of exposure to CMF per day. Samples were collected at 18-24 hours post exposure as well to look at the duration of the effect of the CMF exposure. This cell culture analysis indicates that the potential pathway for the up regulation of bone cell proliferation is due to the increase in synthesis and secretion of IFG-II. The increase in IGF-II was seen at 18-hour post exposure in the cell model. The cellular response was then confirmed in an animal cell culture model for fracture healing. The animal cell culture model showed the effect of CMF on IGF-II varied depending on the state of healing. This up regulation was seen at 24 hours after exposure to CMF.
“ THE EFFECT OF CMF ™ ON IGF-II PRODUCTION WAS MEASURED AFTER 30 MINUTES OF EXPOSURE PER DAY ”
ACCESS THE FULL ABSTRACT AND ARTICLE: HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/ABS/PII/0302459894870160
7
Made with FlippingBook - PDF hosting