Employing catalytic dehydration to access complex scaffolds Mark McLaughlin, Ashley J. Basson, Dean D. Roberts, Thomas K. Britten, Elisabeth L. R. Leonard, Niamh J. Owen Lancaster University, UK The requirement to design processes that produce innocuous by-products has increased dramatically over the last decade, with great strides in many areas of organic synthesis. Although these processes do provide the required products, many of them use stoichiometric reagents to mediate the key dehydration, and therefore work to realise catalytic variants is ongoing. We have disclosed a series of reports detailing our group’s work in this area, with particular focus on calcium and Brønsted acid catalysis. 1-4 This poster will summarise our ongoing, unpublished work in this area, focussing on the development of new methodologies to produce novel or difficult to access scaffolds, including heterocycles, spiro/fused motifs, dienesand functionalised allyl metal species. References
1. Basson, A. J and McLaughlin, M. G* Chem. Commun, 2019, 55, 8317 2. Britten, T. K. and McLaughlin, M. G*J. Org. Chem. 2020, 85, 301 3. Basson, A. J and McLaughlin,M. G*, J. Org. Chem. 2020, 85 , 5615 4. Basson, A. J and McLaughlin, M. G.*, ChemSusChem, 2021 , 14, 1696
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