Sustainable synthesis of useful building blocks enabled by electrolysis in continuous flow Maksim Ošeka Tallinn University of Technology, Estonia Tallinn University of Technology, EstoniaElectrochemistry has recently witnessed a renaissance in modern organic chemistry. This approach uses electrons as traceless and green reagents to generate highly reactive radical species under mild reaction conditions avoiding the utilization of hazardous oxidants or reductants and metal catalysts. Combining electrochemistry with the continuous-flow technology, we managed to obtain highly valuable building block, such as aziridines and electron-rich phenols, starting from common and broadly available starting materials. 1,2 In flow microreactors, high electrode surface-to-volume ratio and effective mixing significantly reduce reaction time, which helps to prevent degradation of sensitive products under the electrochemical conditions and increases reaction selectivity. The continuous nature of the process readily allowed to scale-up the reactions safely and efficiently.
References 1. M. Ošeka, G. Laudadio, N. P. van Leest, M. Dyga, A. d. A. Bartolomeu, L. J. Gooßen, B. de Bruin, K. T. de Oliveira and T. Nol, Chem , 2021, 7 , 255. 2. A. Kooli, L. Wesenberg, M. Beslać, A. Krech, M. Lopp, T. Noёl and M. Ošeka, Eur. J. Org. Chem. , 2022, e202200011.
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