C-O and C-Si bond formation using earth-abundant first-row transition metal catalysis via directing group assisted C-H activation Writhabrata Sarkar, Indubhusan Deb CSIR-Indian Institute of Chemical Biology, India Functional groups like the acetoxy and silyl moieties are extremely important in synthetic organic chemistry, since their incorporation in organic molecules lead to compounds with diversified biological activities, synthetic abilities, and form key components in many fields of science, viz. pharmaceutical, material science, polymer industries, among others, and are also present in a plethora of natural products and drug candidates. 1 These properties make the synthetic generation of C-O and C-Si bonds indispensable in synthetic organic chemistry research area. In recent times, direct and selective acetoxylation and silylation of inert C-H bonds by directing group assisted C-H activation technique is slowly replacing traditional approaches in an atom and step economic manner. 2 In this context, we have developed sustainable methods for first-row transition metal-catalyzed sp 2 C-H acetoxylation 3 as well as direct sp 2 C-H silylation 4 reactions for the synthesis of functionalized molecules. The details of synthesis, substrate scope and mechanism will be discussed during the presentation. References 1. (a) D. E. Nichols, S. Frescas, Synthesis 1999 , 935-938. (b) E. Langkopf, D. Schinzer, Chem. Rev. 1995 , 95 , 1375-1408. 2. (a) A. R. Dick, K. R. Hull, M. S. Sanford, Am. Chem. Soc. 2004 , 126 , 2300-2301. (b) F. Kakiuchi, K. Igi, M. Matsumoto, N. Chatani, S. Murai, Chem. Lett. 2001 , 30 , 422−423. (c) K. S. Kanyiva, Y. Kuninobu, M. Kanai, Org. Lett. 2014 , 16 , 1968−1971. 3. Arkar, A. Bhowmik, A. Mishra, T. K.Vats, I. Deb, Adv. Synth. Catal. 2018 , 360 , 3228-3232. 4. W. Sarkar, A. Mishra, A. Bhowmik, I. Deb, Org. Lett. 2021 , 23, 4521–4526.
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