TEMPO- catalysed green electrochemical synthesis of dimeric 2-oxindole Sulekha Sharma, Amit Paul IISER BHOPAL, India Electro-organic synthesis is a green, sustainable, and economically efficient approach to chemical transformations as it replaces the use of harmful and expensive chemical oxidants/reductants by harnessing the electrode potential. However, there are certain challenges that are still associated with this methodology, such as the use of a large amount of electrolyte, the requirement of high oxidation potential, and tedious steps to carry out the optimization of the reaction. Therefore, the synthesis methodology still doesn’t follow all the principles of green chemistry.Herein, TEMPO-catalyzed electro-oxidative dimerization of 2-oxindole has been carried out andthe reaction becomes appreciably more energy efficient. Besides, more than 90% of the electrolyte used in the reaction was recovered at the end of the reaction and therefore making the reaction significantly greener. Furthermore, the electrochemical rate constant measurement studies were performed to bypass the exhausting steps required for the optimization of the reaction. Hence, the protocol developed herein is much superior compared to the conventional as well as general electro-organic methods. References 1. Jiang, Y.; Xu, K.; Zeng, C. Rev. 2018 , 118 , 4485-4540.Sharma, S.; Roy, A.; Shaw, K.; Bisai, A.; Paul, A. Org. Chem. 2020 , 85 , 14926-14936.
2. Shaw, K.; ‡ harma, S.; ‡ Khatua, A.; Paul, A.; Bisai, A. Biomol. Chem . 2021 , 19 , 9390–9395. 3. (‡Both authors contributed equally to this work.)Y; Lei, A. Nat. Commun. 2020 , 11 , 802.
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